80 completed, 50 recruiting, 40 terminated, 27 active not recruiting. 258 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 258 | Completed 80, Recruiting 50, Terminated 40, Active not recruiting 27, Unknown 27, Not yet recruiting 18, Withdrawn 15, Enrolling by invitation 1 |
Follow Neoplasms, Nerve Tissue: new trials by email Literature Review of Neoplasms, Nerve Tissue trials Research Report on Neoplasms, Nerve Tissue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors [F-18]MeFAMP PET - Healthy Volunteers, Recurrent Glioma | Early Phase 1 | Not yet recruiting | University of Alabama at Birmingham | 28 | 2027-04-01 | 2026-08-20 |
| Oral Gallium Maltolate for Recurrent Glioblastoma Gallium Maltolate, Surgical Intervention - Glioblastoma | Early Phase 1 | Not yet recruiting | Medical College of Wisconsin | 8 | 2027-03-01 | 2026-09-23 |
| Biomarker-guided RAdiation-deferring Treatment in Younger GBM Patients - Pilot Study Larotrectinib, Cadonilimab, Plixorafenib - IDH Wildtype Glioblastoma, Glioblastoma (GBM) | Early Phase 1 | Not yet recruiting | Olivia Newton-John Cancer Research Institute | 12 | 2027-03-01 | 2026-10-30 |
| Window of Opportunity Study of Lixumistat in Patients With Newly Diagnosed Glioblastoma Lixumistat - Cohort 1, Lixumistat - Cohort 2 - Glioblastoma | Early Phase 1 | Recruiting | Macarena De La Fuente, MD | 10 | 2026-12-01 | 2026-10-20 |
| Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG 18F-Fluciclovine - Glioma, Low-grade Glioma | Early Phase 1 | Recruiting | Children's Hospital of Philadelphia | 30 | 2026-11-29 | 2026-09-22 |
| Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade Gliomas avutometinib and defactinib for 3 weeks on/1 week off, MGMT-unmethylated GBM with Radiation - MGMT-unmethylated Glioblastoma (GBM), IDH Wildtype Glioblastoma | Early Phase 1 | Not yet recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 22 | 2026-11-10 | 2026-08-26 |
| Multiparametric Metabolic and Hypoxic PET/MRI Imaging Substudy in Gliomas [18F]FMISO-PET with contrast-enhanced MRI - Glioma | Early Phase 1 | Not yet recruiting | University of Alabama at Birmingham | 20 | 2026-11-01 | 2026-10-30 |
| PICSTAT Pilot Study for CD8 PET/CT-Guided Lifileucel Treatment in Advanced Melanoma Resection of PET (high) and PET (low) Tumors, Lifileucel Manufacturing Clinical v Research, Chemotherapy Regimen - Unresectable or Metastatic Melanoma | Early Phase 1 | Not yet recruiting | Abramson Cancer Center at Penn Medicine | 10 | 2026-10-01 | 2026-07-13 |
| Pilot Radioembolisation Clinical Trial Assessing Safety and Efficacy in Recurrent Glioma SIR-Spheres® - Recurrent Glioblastoma IDH Wildtype, Recurrent Glioblastoma | Early Phase 1 | Not yet recruiting | Olivia Newton-John Cancer Research Institute | 12 | 2026-10-01 | 2026-07-17 |
| A Study of NST-628 in Recurrent Grade 4 Glioma NST-628 - Glioma, Recurrent High Grade, Grade 4 Malignant Glioma | Early Phase 1 | Not yet recruiting | Nader Sanai | 12 | 2026-10-01 | 2026-09-15 |
| Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study ICI Therapy - Gastrointestinal Neoplasms, Genitourinary Cancer | Early Phase 1 | Not yet recruiting | Indiana University | 80 | 2026-09-01 | 2026-07-15 |
| Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer [64Cu]CM500, [68Ga]CM500, PET/MR - Bladder Cancer, Glioma | Early Phase 1 | Not yet recruiting | Lumina Pharmaceuticals Inc | 40 | 2026-09-01 | 2026-08-28 |
| Safety, Tolerability, and Preliminary Efficacy of [211At]MABG in Patients With Relapsed or Refractory Neuroblastoma [211At]MABG - Neuroblastoma (NB) | Early Phase 1 | Recruiting | Sichuan University | 10 | 2026-07-21 | 2026-08-21 |
| Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures Panitumumab-IRDye800 - Meningioma, Glioblastoma | Early Phase 1 | Recruiting | Eben Rosenthal | 30 | 2026-07-07 | 2026-10-16 |
| Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent Glioblastoma [177Lu]Lu-XT771 - Recurrent Glioblastoma (WHO-Grade IV Glioma), Recurrent Glioblastoma | Early Phase 1 | Recruiting | Beijing Tiantan Hospital | 5 | 2026-06-20 | 2026-06-16 |
| Imaging Acetadote Metabolism in Glioblastoma Acetadote - Glioblastoma, GBM | Early Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 10 | 2026-06-18 | 2026-06-23 |
| Evaluation of [⁶⁸Ga/¹⁷⁷Lu]HT547: Safety, Biodistribution, and Dosimetry in Solid Tumors [⁶⁸Ga]Ga-HT547 and [¹⁷⁷Lu]Lu-HT547 - Breast Cancer, Head and Neck Cancer (H&N) | Early Phase 1 | Not yet recruiting | Hua Pang | 20 | 2026-06-01 | 2026-06-10 |
| BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted Tumors BGB-58067 - Glioblastoma (GBM) | Early Phase 1 | Recruiting | Nader Sanai | 78 | 2026-05-07 | 2026-08-21 |
| Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors Methionine-Reduced Diet - Adenocarcinoma, Basal Cell Carcinoma | Early Phase 1 | Recruiting | University of California, Irvine | 25 | 2026-05-01 | 2026-07-31 |
| Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) Nivolumab, Nivolumab-IRDye800 - Brain Cancer, HGG | Early Phase 1 | Recruiting | Eben Rosenthal | 38 | 2026-03-27 | 2026-07-01 |
Showing 20 of 258. Sign in to see all of them.
Glioblastoma (88) · Glioma (70) · Melanoma (56) · Brain Neoplasms (34) · Neuroendocrine Tumors (18) · Breast Neoplasms (15) · Neuroblastoma (15) · Astrocytoma (14) · Neoplasms (11) · Lung Neoplasms (9) · Medulloblastoma (9) · Sarcoma (9) · Gliosarcoma (8) · Oligodendroglioma (8) · Diffuse Intrinsic Pontine Glioma (7)
Neoplasms by Histologic Type (258) · Neuroectodermal Tumors (253) · Neoplasms, Germ Cell and Embryonal (251) · Neoplasms (247) · Neoplasms, Glandular and Epithelial (188) · Neoplasms, Neuroepithelial (173) · Neoplasms by Site (120) · Glioma (82) · Astrocytoma (81) · Neuroendocrine Tumors (66) · Skin and Connective Tissue Diseases (61) · Skin Diseases (60) · Nervous System Diseases (59) · Nevi and Melanomas (58)
Magnetic Resonance Spectroscopy (16) · Temozolomide (15) · Nivolumab (11) · Radiotherapy (10) · gallium Ga 68 dotatate (7) · pembrolizumab (7) · Bevacizumab (6) · Ipilimumab (6) · Topotecan (6) · Cyclophosphamide (5) · Specimen Handling (5) · fluciclovine F-18 (5) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (4) · 3-Iodobenzylguanidine (4) · Biopsy (4)
Mayo Clinic (15) · Nader Sanai (11) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (8) · Memorial Sloan Kettering Cancer Center (7) · Peking Union Medical College Hospital (7) · H. Lee Moffitt Cancer Center and Research Institute (6) · Case Comprehensive Cancer Center (5) · M.D. Anderson Cancer Center (5) · Massachusetts General Hospital (5) · Washington University School of Medicine (5) · Abramson Cancer Center at Penn Medicine (4) · Beijing Tiantan Hospital (4) · Emory University (4) · St. Joseph's Hospital and Medical Center, Phoenix (4) · University of Alabama at Birmingham (4)
United States (176) · China (34) · Australia (8) · Canada (6) · Germany (4) · Switzerland (4) · France (3) · Netherlands (3) · Italy (2) · New Zealand (2) · Sweden (2) · Argentina (1) · Austria (1) · Belarus (1) · Brazil (1)
Nader Sanai, MD (13) · Frank Lieberman, MD (3) · Maryam Fouladi, MD (3) · Nadia N. Laack, M.D. (3) · Terence C. Burns, MD, PhD (3) · David Bushnell, MD (2) · David Sandberg, MD (2) · Ian Parney (2) · Jeffrey J. Olson, MD (2) · Jiayi Huang, M.D. (2) · Joanna Kolodney, MD (2) · Mariam Aboian, MD,PhD (2) · Michael A Vogelbaum, MD, PhD (2) · Mustafa Khasraw, MBChB, MD, FRCP, FRACP (2) · Scott Plotkin, MD, PhD (2)
PMID 19660720, PMID 21252315, PMID 22499613, PMID 23112884, PMID 24344045, PMID 25179634, PMID 26330458, PMID 26380086, PMID 26581199, PMID 26943915, PMID 28360208, PMID 29307718, PMID 29652233, PMID 29798906, PMID 29973204, PMID 30002107, PMID 32206976, PMID 32431667, PMID 32752904, PMID 32874573, PMID 33955240, PMID 34081125, PMID 34146130, PMID 34171339, PMID 34667843, PMID 35428211, PMID 35551087, PMID 35574391, PMID 35657429, PMID 35861778, PMID 36355259, PMID 36549916, PMID 36923556, PMID 37160439, PMID 37175874, PMID 37344887, PMID 37377890, PMID 38581480, PMID 38719544, PMID 38883740, PMID 39112464, PMID 39140289, PMID 39386211, PMID 39806560, PMID 39821814, PMID 40135850, PMID 40717185, PMID 40841487, PMID 40913745, PMID 41206763
P30CA015083 (3), P30CA138292 (3), P50CA174521 (3), P30CA012197 (2), R21CA133859 (2), ZIAEB000073 (2), 2016 (1), 2018 (1), 2019 (1), 2023 (1), 2025 (1), P01CA118816 (1), P30CA006973 (1), P30CA014089 (1), P30CA046934 (1)