7 completed, 6 recruiting, 3 active not recruiting, 2 terminated. 9 Phase 2, 4 Phase 3, 3 Not applicable, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Active not recruiting 3, Completed 3, Recruiting 2, Terminated 1 |
| Phase 3 | 4 | Completed 4 |
| Not applicable | 3 | Recruiting 3 |
| Phase 1 | 3 | Active not recruiting 1, Recruiting 1, Terminated 1 |
Follow Myeloid Neoplasm: new trials by email Literature Review of Myeloid Neoplasm trials Research Report on Myeloid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomization for the Identification of Best Treatment Intensity for Less Fit Adults With Acute Myeloid Leukemia and Myeloid Neoplasms Biospecimen Collection, Bone Marrow Collection, Electronic Health Record Review - Acute Leukemia of Ambiguous Lineage, Acute Myeloid Leukemia | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 50 | 2026-10-13 | 2026-10-19 |
| Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia Activity Tracking, Biospecimen Collection, Cognitive Assessment - Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | Not applicable | Recruiting | University of Washington | 50 | 2025-10-15 | 2026-08-19 |
| A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies Decitabine, Filgrastim - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 2 | Active not recruiting | Franziska Wachter | 29 | 2023-04-19 | 2026-08-20 |
| Study of CPX-351 (VYXEOS) in Individuals < 22 Years With Secondary Myeloid Neoplasms CPX-351, MHA, Allogeneic Hematopoietic Stem Cell Transplantation - Myeloid Neoplasm | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 25 | 2023-01-17 | 2026-10-15 |
| Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms Cladribine, Cytarabine, Mitoxantrone - Acute Biphenotypic Leukemia, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Recruiting | University of Washington | 62 | 2022-02-04 | 2026-04-17 |
| A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms GO-EXCAP Mobile App, Behavioral Placebo Control - Cancer, Myeloid Neoplasm | Not applicable | Recruiting | University of Rochester | 170 | 2022-01-03 | 2026-07-15 |
| Two Step Haplo With Radiation Conditioning Fludarabine, Total-Body Irradiation, Donor Lymphocyte Infusion - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | Thomas Jefferson University | 63 | 2021-10-25 | 2025-10-30 |
| CPX-351 Versus Immediate Stem Cell Transplantation for the Treatment of High-Grade Myeloid Cancers With Measurable Residual Disease Allogeneic Hematopoietic Stem Cell Transplantation, Liposome-encapsulated Daunorubicin-Cytarabine - Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2 | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 1 | 2021-08-09 | 2024-05-23 |
| CPX-351 or CLAG-M Regimen for the Treatment of Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms in Medically Less-Fit Patients Liposome-encapsulated Daunorubicin-Cytarabine, Cladribine, Cytarabine - Acute Myeloid Leukemia, Myeloid Neoplasm | Phase 2 | Completed | Fred Hutchinson Cancer Center | 60 | 2020-05-27 | 2026-06-29 |
| Continuous Infusion Chemotherapy (CI-CLAM) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms Cladribine, Cytarabine, Recombinant Granulocyte Colony-Stimulating Factor - Myeloid Neoplasm, Recurrent Acute Myeloid Leukemia | Phase 1 | Terminated | University of Washington | 13 | 2020-05-08 | 2023-12-28 |
| The Myeloid Neoplasms Biology and Outcome Project Myeloid Neoplasm | Recruiting | University Hospital Heidelberg | 1000 | 2020-03-10 | 2025-03-25 | |
| Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Azacitidine, Pevonedistat, Venetoclax - Acute Myeloid Leukemia, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 40 | 2019-02-27 | 2026-07-16 |
| Higher or Lower Dose Cladribine, Cytarabine, and Mitoxantrone in Treating Medically Less Fit Patients With Newly Diagnosed Acute Myeloid Leukemia or Myeloid Neoplasm Cladribine, Cytarabine, Granulocyte Colony-Stimulating Factor - Acute Leukemia of Ambiguous Lineage, Acute Myeloid Leukemia | Phase 2 | Completed | University of Washington | 50 | 2016-12-30 | 2022-03-08 |
| Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms Cladribine, Cyclosporine, Cytarabine - Blasts 10 Percent or More of Bone Marrow Nucleated Cells, Chronic Myelomonocytic Leukemia-2 | Phase 2 | Completed | University of Washington | 30 | 2016-09-22 | 2021-11-08 |
| Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant Chlorhexidine Gluconate Skin Cleanser, Laboratory Biomarker Analysis, Mild Soap Skin Cleanser - Bacterial Infection, Benign Neoplasm | Phase 3 | Completed | Children's Oncology Group | 177 | 2013-11-04 | 2021-06-22 |
| Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Asparaginase, Bortezomib, Cytarabine - Acute Myeloid Leukemia, Leukemia Cutis | Phase 3 | Completed | National Cancer Institute (NCI) | 1645 | 2011-07-06 | 2026-06-02 |
| Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Caspofungin Acetate, Fluconazole, Laboratory Biomarker Analysis - Acute Myeloid Leukemia, Adult Acute Monoblastic Leukemia | Phase 3 | Completed | Children's Oncology Group | 517 | 2011-04-04 | 2021-03-30 |
| Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia Arsenic Trioxide, Cytarabine, Diagnostic Laboratory Biomarker Analysis - Childhood Acute Promyelocytic Leukemia With PML-RARA, Myeloid Neoplasm | Phase 3 | Completed | Children's Oncology Group | 106 | 2009-03-09 | 2022-10-25 |
Leukemia, Myeloid, Acute (14) · Myelodysplastic Syndromes (5) · Leukemia, Monocytic, Acute (4) · Leukemia, Biphenotypic, Acute (3) · Leukemia, Myelomonocytic, Chronic (2) · Neoplasms (2) · Polycythemia Vera (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Primary Myelofibrosis (2) · Sarcoma, Myeloid (2) · Thrombocythemia, Essential (2) · Anemia, Aplastic (1) · Bacterial Infections (1) · Burkitt Lymphoma (1) · Congenital Bone Marrow Failure Syndromes (1)
Hematologic Diseases (15) · Hemic and Lymphatic Diseases (15) · Neoplasms by Histologic Type (15) · Leukemia (14) · Leukemia, Myeloid (14) · Neoplasms (14) · Immune System Diseases (6) · Immunoproliferative Disorders (6) · Leukemia, Lymphoid (6) · Lymphatic Diseases (6) · Lymphoproliferative Disorders (6) · Bone Marrow Diseases (5) · Infections (3) · Myelodysplastic-Myeloproliferative Diseases (3) · Bacterial Infections and Mycoses (2)
Cytarabine (9) · Mitoxantrone (7) · Cladribine (5) · Daunorubicin (4) · CPX-351 (3) · Granulocyte Colony-Stimulating Factor (3) · Specimen Handling (3) · Stem Cell Transplantation (3) · pegylated granulocyte colony-stimulating factor (3) · Filgrastim (2) · Injections (2) · Liposomes (2) · Melphalan (2) · Methotrexate (2) · Mycophenolic Acid (2)
University of Washington (5) · Children's Oncology Group (3) · Fred Hutchinson Cancer Center (3) · Franziska Wachter (1) · M.D. Anderson Cancer Center (1) · National Cancer Institute (NCI) (1) · St. Jude Children's Research Hospital (1) · Thomas Jefferson University (1) · University Hospital Heidelberg (1) · University of Rochester (1)
United States (17) · Canada (4) · Puerto Rico (4) · Australia (1) · Germany (1) · New Zealand (1)
Anna Halpern (1) · Anna Halpern, MD (1) · Danielle M Zerr (1) · Filippo Milano (1) · Franziska Wachter, MD (1) · Jacob Appelbaum, MD, PhD (1) · John J Gregory (1) · Kah Poh Loh (1) · Marcin Wlodarski, MD, PhD (1) · Mary-Beth M. Percival (1) · Mary-Beth Percival, MD (1) · Mary-Elizabeth Percival (1) · Nicholas Short (1) · Raul C. Ribeiro, MD (1) · Richard Aplenc (1)
PMID 28419486, PMID 30773463, PMID 30987448, PMID 31688884, PMID 32029509, PMID 34596937, PMID 34855461, PMID 35349331, PMID 36815378, PMID 37254221, PMID 37267439, PMID 37422688, PMID 38295280, PMID 40294366, PMID 40535475, PMID 42054674, PMID 42085603
P30CA015704 (2), U10CA095861 (2), U10CA098543 (2), UG1CA189955 (2), R00CA237744 (1), R01CA163394 (1), U10CA180886 (1)