317 completed, 89 terminated, 64 recruiting, 46 unknown. 326 Phase 2, 217 Phase 1, 45 Phase 3, 29 Not applicable, 8 Phase 4.
Follow Myelodysplastic Syndrome: new trials by email Literature Review of Myelodysplastic Syndrome trials Research Report on Myelodysplastic Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Monzosertib In Patients With R/R AML Or High-Risk Myelodysplastic Syndrome Monzosertib, Posaconazole, Isavuconazole - Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome | Phase 1 | Not yet recruiting | M.D. Anderson Cancer Center | 42 | 2027-01-01 | 2026-08-21 |
| Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration - Acute Biphenotypic Leukemia, Acute Leukemia | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 52 | 2027-01-01 | 2026-09-14 |
| A Trial Comparing Three Different Treatment Options for Adults With Low-Risk Myelodysplasia and Anemia (A MyeloMATCH Treatment Trial) Biospecimen Collection, Bone Marrow Aspiration, Emavusertib - Myelodysplastic Syndrome | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 270 | 2026-12-18 | 2026-09-22 |
| Prophylactic DLI-X for Leukemia Relapse After HCT Exercise Mobilized Prophylactic DLI, Standard Prophylactic DLI - Acute Lymphoid Leukemia, Acute Myeloid Leukemia | Phase 1 | Not yet recruiting | University of Arizona | 180 | 2026-11-30 | 2026-10-22 |
| Testing the Use of an IDH1 Inhibitor, Olutasidenib, in Acute Myeloid Leukemia Added to ASTX727 and Venetoclax; in High-Risk MDS Added to ASTX727; and Alone in Low Risk MDS (A MyeloMATCH Treatment Substudy) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Acute Myeloid Leukemia, Myelodysplastic Syndrome | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 132 | 2026-11-27 | 2026-09-09 |
| Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography - Acute Myeloid Leukemia With Complex Karyotype, Myelodysplastic Chronic Myelomonocytic Leukemia | Phase 2 | Recruiting | City of Hope Medical Center | 35 | 2026-11-05 | 2026-10-08 |
| Arsenic Trioxide to Prevent Relapse in Patients Undergoing Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia or Myelodysplastic Syndrome Allogeneic Hematopoietic Stem Cell Transplantation, Arsenic Trioxide, Biospecimen Collection - Acute Myeloid Leukemia, Myelodysplastic Syndrome | Phase 1 | Not yet recruiting | University of Michigan Rogel Cancer Center | 20 | 2026-11-01 | 2026-07-30 |
| CHIP in Health and Disease Clonal Hematopoiesis, Clonal Hematopoiesis of Indeterminate Potential | Not yet recruiting | VASCage GmbH | 120 | 2026-10-01 | 2026-09-21 | |
| Allogeneic iNKT Cell Therapy (agenT-797) After SCT agenT-797 - Allogenic Stem Cell Transplantation, Myeloid Malignancies | Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 22 | 2026-10-01 | 2026-10-13 |
| Peri-graft Cytokine Profile: Influence of Hematologic Disease and Donor Type Blood sampling - Myelofibrosis, Acute Leukemia | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 96 | 2026-09-15 | 2026-09-04 | |
| CD64 CAR T Cell Therapy in Adults With Relapsed and/or Refractory AML CD64 CAR T Cells - Refractory Acute Myeloid Leukemia (AML), Relapsed Acute Myeloid Leukemia (AML) | Phase 1 | Recruiting | University of Colorado, Denver | 23 | 2026-09-10 | 2026-10-20 |
| Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation QUAIL-100 - Acute Leukemia, Myelodysplastic Syndrome | Phase 1 | Recruiting | Laguna Biotherapeutics, Inc. | 12 | 2026-08-01 | 2026-08-21 |
| Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant Biospecimen Collection, Busulfan, Computed Tomography - Acute Myeloid Leukemia, Graft Versus Host Disease | Phase 1 | Recruiting | City of Hope Medical Center | 15 | 2026-06-12 | 2026-07-01 |
| Study of NK Cells in the Monitoring of Patients With Acute Leukemia or Myelodysplasia Bone marrow sampling (during routine care), Blood samples (during routine care) - Leukaemia (Acute Myeloid), Leukaemia (Acute Lymphoblastic) | Not yet recruiting | Nantes University Hospital | 55 | 2026-06-01 | 2026-06-24 | |
| A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Lower Risk Myelodysplastic Syndromes (LR-MDS) Who Need Regular Blood Transfusions Elritercept, Epoetin Alfa - Myelodysplastic Syndrome, Anemia | Phase 3 | Recruiting | Takeda | 300 | 2026-05-21 | 2026-10-19 |
| Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial) Nicotinamide Riboside, Pterostilbene - Clonal Cytopenia of Undetermined Significance, Myelodysplastic Syndrome | Phase 2 | Recruiting | University of Colorado, Denver | 10 | 2026-05-20 | 2026-06-03 |
| A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant Biospecimen Collection, Electronic Health Record Review, Haploidentical Hematopoietic Cell Transplantation - Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 1 | Recruiting | City of Hope Medical Center | 46 | 2026-05-08 | 2026-07-28 |
| Observational Study on Eltrombopag in Hypocellular Myelodysplastic Neoplasms Eltrombopag (ELT) - Myelodysplastic Neoplasm, Myelodysplastic Syndrome | Active not recruiting | Fondazione Italiana Sindromi Mielodisplastiche-ETS | 100 | 2026-05-01 | 2026-09-17 | |
| Study of an Innovative Therapy Using CAR-T Cells Targeting IL-1RAP in Patients With High-Risk Myelodysplastic Syndromes (MDS Bone marrow and blood sampling - Myelodysplastic Syndrome | Not applicable | Not yet recruiting | University Hospital, Grenoble | 120 | 2026-05-01 | 2026-03-06 |
| Safety and Proof-of-Concept Study of RPT1G in Adults With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes RPT1G - Acute Myeloid Leukemia, Myelodysplastic Syndrome | Phase 1 | Recruiting | Remedy Plan, Inc. | 24 | 2026-02-13 | 2026-03-25 |
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Myelodysplastic Syndromes (602) · Leukemia, Myeloid, Acute (343) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (149) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (114) · Leukemia (101) · Lymphoma, Non-Hodgkin (96) · Multiple Myeloma (80) · Hodgkin Disease (79) · Leukemia, Myelomonocytic, Chronic (73) · Leukemia, Lymphocytic, Chronic, B-Cell (63) · Myeloproliferative Disorders (63) · Hematologic Neoplasms (46) · Lymphoma (42) · Primary Myelofibrosis (38) · Leukemia, Biphenotypic, Acute (31)
Hemic and Lymphatic Diseases (602) · Bone Marrow Diseases (601) · Hematologic Diseases (593) · Neoplasms by Histologic Type (450) · Neoplasms (441) · Leukemia, Myeloid (384) · Leukemia (338) · Immune System Diseases (232) · Immunoproliferative Disorders (228) · Lymphatic Diseases (223) · Lymphoproliferative Disorders (222) · Pathological Conditions, Signs and Symptoms (207) · Pathologic Processes (205) · Disease Attributes (201) · Chronic Disease (190)
Azacitidine (76) · Cyclophosphamide (74) · fludarabine (62) · fludarabine phosphate (55) · Busulfan (47) · Tacrolimus (47) · Whole-Body Irradiation (47) · Decitabine (42) · Mycophenolic Acid (38) · Cytarabine (37) · Specimen Handling (32) · Melphalan (30) · Antilymphocyte Serum (29) · Stem Cell Transplantation (29) · Clofarabine (27)
M.D. Anderson Cancer Center (80) · City of Hope Medical Center (27) · Fred Hutchinson Cancer Center (27) · National Cancer Institute (NCI) (22) · Memorial Sloan Kettering Cancer Center (19) · Celgene (11) · Masonic Cancer Center, University of Minnesota (11) · St. Jude Children's Research Hospital (9) · Dana-Farber Cancer Institute (8) · Traws Pharma, Inc. (8) · Weill Medical College of Cornell University (8) · Massachusetts General Hospital (7) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (7) · National Heart, Lung, and Blood Institute (NHLBI) (6) · Novartis Pharmaceuticals (6)
United States (440) · Germany (34) · France (33) · Canada (31) · United Kingdom (28) · Italy (26) · China (25) · Spain (22) · South Korea (21) · Japan (17) · Belgium (16) · Israel (16) · Australia (14) · Denmark (12) · Netherlands (12)
Guillermo Garcia-Manero, MD (8) · Guillermo Garcia-Manero (5) · Katsuhisa Goto (5) · Qifa Liu (5) · Hagop Kantarjian, MD (4) · Monzr M Al Malki (4) · Ryotaro Nakamura, MD (4) · A. John Barrett, M.D. (3) · Anna Halpern (3) · Courtney DiNardo, MD (3) · Denis Claude Roy, Prof MD (3)
PMID 23065508, PMID 23524640, PMID 27400247, PMID 23260600, PMID 23790798, PMID 10204198, PMID 10339508, PMID 10577848, PMID 12370753, PMID 12393746, PMID 14603333, PMID 15020610, PMID 15124687, PMID 15197203, PMID 15368330, PMID 15534356, PMID 16522815, PMID 17021321, PMID 17252015, PMID 17579184, PMID 17596541, PMID 18042004, PMID 18055864, PMID 18565853, PMID 19284416, PMID 19546476, PMID 19557623, PMID 19652201, PMID 19667400, PMID 20117965, PMID 20421274, PMID 20733120, PMID 20946966, PMID 21381892, PMID 21659356, PMID 21659363, PMID 21841163, PMID 21924492, PMID 21976674, PMID 22047558, PMID 22072492, PMID 22080968, PMID 22133778, PMID 22198310, PMID 22422826, PMID 22546242, PMID 22547163, PMID 22547607, PMID 22609885, PMID 22816487
P30CA033572 (16), P30CA015704 (14), P30CA016672 (5), 2009 (3), 2017 (3), P30CA006973 (3), U01CA070095 (3), U10CA180821 (3), U10CA180886 (3), U10CA180888 (3), 2005 (2), 2014 (2), 2015 (2), 2016 (2), 2023 (2)