2 recruiting. 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 2 | Recruiting 2 |
Follow Mild Autonomous Cortisol Secretion (MACS): new trials by email Literature Review of Mild Autonomous Cortisol Secretion (MACS) trials Research Report on Mild Autonomous Cortisol Secretion (MACS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS) Osilodrostat (Isturisa) - Mild Autonomous Cortisol Secretion (MACS) | Phase 4 | Recruiting | Johns Hopkins University | 10 | 2026-02-02 | 2026-10-23 |
| Metyrapone Versus Osilodrostat in Patients With Metabolic Autonomous Cortisol Secretion (MACS) Metyrapone 250 mg Oral Tablets, Osilodrostat 1 MG, adrenalectomy - Mild Autonomous Cortisol Secretion (MACS) | Phase 4 | Recruiting | Laikο General Hospital, Athens | 150 | 2025-12-01 | 2025-12-05 |
ACTH Syndrome, Ectopic (1) · Adrenal Hyperplasia, Congenital (1) · Hypertension (1)
Adrenal Gland Diseases (1) · Adrenogenital Syndrome (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Disorders of Sex Development (1) · Endocrine System Diseases (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Genetic Diseases, Inborn (1) · Gonadal Disorders (1) · Male Urogenital Diseases (1) · Metabolic Diseases (1) · Metabolism, Inborn Errors (1) · Neoplasms (1)
Osilodrostat (2) · Adrenalectomy (1) · Metyrapone (1) · Surgical Procedures, Operative (1)
Johns Hopkins University (1) · Laikο General Hospital, Athens (1)
Greece (1) · United States (1)
PMID 27454103, PMID 28887710, PMID 29510982, PMID 30817193, PMID 31206616, PMID 35220871, PMID 3536461, PMID 35817047, PMID 36952249, PMID 37318239, PMID 37801655, PMID 39062179, PMID 39086899, PMID 6135282