11 unknown, 9 completed, 4 not yet recruiting, 4 recruiting. 27 Not applicable, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 27 | Unknown 10, Completed 6, Not yet recruiting 4, Recruiting 4, Suspended 2, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Malignant Biliary Obstruction: new trials by email Literature Review of Malignant Biliary Obstruction trials Research Report on Malignant Biliary Obstruction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suprapapillary Versus Transpapillary Plastic Stents for Unresectable Malignant Hilar Biliary Obstruction Suprapapillary plastic stent placement, Transpapillary plastic stent placement - Biliary Tract Neoplasms, Biliary Drainage | Not applicable | Not yet recruiting | National Taiwan University Hospital | 70 | 2026-09-01 | 2026-09-10 |
| Suprapapillary Metal Stent vs. Routine Transpapillary Drainage in Malignant Hilar Biliary Obstruction (SMART-B Trial) Percutaneous transpapillary internal-external biliary drainage, Percutaneous suprapapillary biliary drainage with self-expanding metal stent - Cholangiocarcinoma, Bile Duct Neoplasms | Not applicable | Recruiting | Hospital de Clinicas de Porto Alegre | 84 | 2026-06-24 | 2026-10-01 |
| 12-mm Partial Covered Versus Bare Self-Expandable Metallic Stents for Malignant Distal Biliary Obstruction 12-mm partially covered self-expandable metallic stent, 12-mm bare self-expandable metallic stent - Malignant Distal Biliary Obstruction, Malignant Biliary Obstruction | Not applicable | Recruiting | Chung-Ang University Hospital | 60 | 2026-05-27 | 2026-07-13 |
| Comparison of a Short Modified Metal Stent Versus Plastic Stent as a Bridge to Surgery in Pancreatic Cancer With Malignant Biliary Obstruction Modified 8-mm Fully Covered Self-Expandable Metal Stent, Plastic stent - Pancreatic Cancer, Malignant Biliary Obstruction | Not applicable | Not yet recruiting | Soonchunhyang University Hospital | 116 | 2026-05-01 | 2026-05-26 |
| Endoscopic Ultrasound Guided Hepaticogastrostomy With or Without Antegrade Stenting for Palliation of Malignant Distal Biliary Obstruction: Randomized Controlled Trial HGAS, HGS - Malignant Biliary Obstruction, Malignant Biliary Stricture | Not applicable | Recruiting | National Taiwan University Hospital | 88 | 2026-04-01 | 2026-09-21 |
| Improving a Bile Duct Drainage Procedure in Patients With Inoperable Cancer Blocking the Bile Ducts: Comparing Two Types of Endoscopically Placed Internal Stents to Prevent Blockage of a Lumen Apposing Metal Stent Fully covered self expanding metal stent (FCSEMS) within LAMS, Double pigtail stent (DPS) within LAMS - Malignant Biliary Obstruction, Advanced Pancreatic Cancer and Cholangiocarcinoma | Not applicable | Not yet recruiting | Waikato Hospital | 100 | 2025-09-01 | 2025-08-11 |
| RIVOS Feasibility (MBO) EUS access device - Malignant Biliary Obstruction | Not applicable | Withdrawn | Boston Scientific Corporation | 2025-08-31 | 2025-09-22 | |
| EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction (CARPEDIEM Trial) Endoscopic biliary drainage, Self-expandable metallic stent (SEMS), Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS) - Malignant Biliary Obstruction, Pancreatic Cancer | Not applicable | Suspended | Hospital Universitari de Bellvitge | 120 | 2025-05-06 | 2026-05-06 |
| EUS-Gallbladder vs CDS as First Line in MBDO- Palliative (CARPEGIEM Trial) Endoscopic biliary drainage, Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS) - Malignant Biliary Obstruction, Biliary Tract Neoplasms | Not applicable | Suspended | Hospital Universitari de Bellvitge | 128 | 2024-10-18 | 2026-05-06 |
| PROceeding With Advanced Techniques in Case of Distal Malignant Biliary Obstruction and Difficult Biliary Cannulation comparEd With Therapeutic-EUS: the PROMETHEUS Trial pre-cut biliary sphincterotomy/fistulotomy, double guide wire (DGW) technique - Malignant Biliary Obstruction | Not applicable | Unknown | Istituto Clinico Humanitas | 220 | 2024-10-01 | 2024-08-13 |
| EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM-1 Trial) Endoscopic biliary drainage, Self-expandable metallic stent (SEMS), Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS) - Malignant Biliary Obstruction, Pancreatic Cancer Resectable | Not applicable | Unknown | Hospital Universitari de Bellvitge | 44 | 2024-05-01 | 2024-04-19 |
| EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial) Endoscopic biliary drainage, Self-expandable metallic stent (SEMS), Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS) - Malignant Biliary Obstruction, Pancreatic Cancer | Not applicable | Not yet recruiting | Hospital Universitari de Bellvitge | 96 | 2024-05-01 | 2024-04-19 |
| EUS-guided Hepatico-gastrostomy With Hot Giobor EUS-guided hepatico-gastrostomy would be performed with Niti-S HOT Giob - Malignant Biliary Obstruction | Not applicable | Unknown | Chinese University of Hong Kong | 30 | 2023-06-15 | 2023-06-02 |
| Multihole Fully Covered Metallic Stents in the Management of Malignant Biliary Obstruction group 1, group 2, group 3 - Malignant Biliary Obstruction | Not applicable | Completed | Zagazig University | 50 | 2023-03-28 | 2024-07-24 |
| The ID- RFA Trial: A Trial of Intraductal Radio-frequency Ablation (ID-RFA) Plus Biliary Stenting Versus Biliary Stenting Alone for the Treatment of Malignant Biliary Obstruction. Intraductal Radio-Frequency Ablation, Biliary Stent Placement - Malignant Biliary Obstruction | Not applicable | Unknown | University Hospitals Dorset NHS Foundation Trust | 24 | 2022-09-16 | 2023-05-11 |
| EUS-guided Hepatico-gastrostomy Using a Novel Lumen Apposing Metal Stent EUS-guided hepaticogastrostomy - Malignant Biliary Obstruction | Not applicable | Recruiting | Chinese University of Hong Kong | 20 | 2022-01-15 | 2026-03-20 |
| Palliation of Gastric Outflow Obstruction in Case of Concomitant Biliary Obstruction. EUS-CD, EUS-GEA - Malignant Biliary Obstruction | Not applicable | Unknown | Istituto Clinico Humanitas | 500 | 2021-12-15 | 2022-02-22 |
| A Comparison of a Fully Covered Self-expandable Metal Stent With an External Anchoring Plastic Stent and Uncovered Stent fully covered self-expandable metal stent with an anchoring external plastic stent, uncovered self-expandable metal stent - Malignant Biliary Obstruction | Not applicable | Unknown | Seoul National University Hospital | 108 | 2021-10-25 | 2022-02-02 |
| Biliary Obstruction of Neoplastic Origin Treated With Drainage. A Prognostic Study. Malignant Biliary Obstruction | Completed | University Hospital, Brest | 372 | 2021-07-15 | 2024-08-13 | |
| EUS-Guided Choledochoduodenostomy Versus ERCP for Primary Biliary Decompression in Distal Malignant Biliary Obstruction Biliary drainage - Malignant Biliary Obstruction | Not applicable | Completed | Mansoura University | 100 | 2021-07-01 | 2024-12-27 |
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Biliary Tract Neoplasms (5) · Cholangiocarcinoma (3) · Pancreatic Neoplasms (3) · Bile Duct Neoplasms (1) · Bites and Stings (1) · Carcinoma, Hepatocellular (1) · Choledocholithiasis (1) · Cholelithiasis (1) · Cholestasis (1) · Constriction, Pathologic (1) · Jaundice, Obstructive (1) · Neoplasms (1)
Digestive System Diseases (10) · Neoplasms (10) · Biliary Tract Diseases (8) · Digestive System Neoplasms (8) · Neoplasms by Site (8) · Adenocarcinoma (4) · Carcinoma (4) · Neoplasms by Histologic Type (4) · Neoplasms, Glandular and Epithelial (4) · Bile Duct Diseases (3) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Pancreatic Diseases (3) · Pathological Conditions, Signs and Symptoms (2) · Biliary Tract Neoplasms (1)
Self Expandable Metallic Stents (3) · Cholangiopancreatography, Endoscopic Retrograde (2) · Methods (1) · Radiofrequency Ablation (1) · Sphincterotomy, Endoscopic (1)
Hospital Universitari de Bellvitge (4) · Chinese University of Hong Kong (3) · First People's Hospital of Hangzhou (2) · Istituto Clinico Humanitas (2) · National Taiwan University Hospital (2) · Seoul National University Hospital (2) · Boston Scientific Corporation (1) · Chung-Ang University Hospital (1) · Hospital de Clinicas de Porto Alegre (1) · Institut Paoli-Calmettes (1) · Mansoura University (1) · Memorial Sloan Kettering Cancer Center (1) · Military Medical Clinical Center of the Southern Region, Ukraine (1) · Samsung Medical Center (1) · Soonchunhyang University Hospital (1)
China (5) · South Korea (5) · Spain (4) · Belgium (3) · France (3) · Egypt (2) · Hong Kong (2) · Taiwan (2) · Australia (1) · Brazil (1) · Denmark (1) · India (1) · Italy (1) · Japan (1) · New Zealand (1)
Joan B Gornals, PhD (3) · Sang Hyub Lee, MD, PhD (2) · Ahmed G Deiab, A.Professor (1) · Ahmed M Gaheen, MSc. (1) · Ahmed Y Altonbary, MD (1) · Anthony Teoh, FRCSEd(Gen (1) · Carme Loras (1) · Cleber R. P. Kruel, Professor (1) · Fabrice Caillol (1) · Gao-jun Teng, Ph.D,MD (1) · Hazem H Alminshawy, Professor (1) · Jianfeng Yang (1) · Joan B Gornals Soler (1) · Jong Kyun Lee, MD PhD (1)
PMID 37121331, PMID 37069476, PMID 29961772, PMID 34748675, PMID 1281903, PMID 15082593, PMID 27864713, PMID 29331343, PMID 29463614, PMID 29605722, PMID 37549753, PMID 38262462, PMID 38382887, PMID 38421018, PMID 38648989, PMID 9852446