6 completed, 3 terminated, 3 unknown. 4 Phase 1, 3 Phase 2, 2 Phase 3, 1 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Not applicable | 1 | Terminated 1 |
| Phase 4 | 1 | Completed 1 |
Follow Lymphoblastic Leukemia, Acute: new trials by email Literature Review of Lymphoblastic Leukemia, Acute trials Research Report on Lymphoblastic Leukemia, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of PD5K3 in Healthy Adult Volunteers PD5K3, Placebo, Pegaspargase - Lymphoblastic Leukemia, Acute, Lymphoblastic Lymphoma | Phase 1 | Completed | Chongqing Peg-Bio Biopharm Co., Ltd. | 28 | 2023-11-27 | 2024-07-30 |
| Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy Marqibo - ALL, Childhood, Lymphoblastic Leukemia, Acute, Childhood | Phase 1 | Completed | Therapeutic Advances in Childhood Leukemia Consortium | 29 | 2017-01-31 | 2025-10-22 |
| Tyrosine Kinase Inhibitors and Low Intensity Chemotherapy in Ph+ ALL Lymphoblastic Leukemia, Acute | Unknown | Versailles Hospital | 100 | 2012-12-01 | 2018-07-30 | |
| EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL) EZN-3042, Cytarabine, Doxorubicin - Lymphoblastic Leukemia, Acute, Lymphoblastic Leukemia, Acute, Childhood | Phase 1 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 6 | 2010-08-24 | 2024-02-01 |
| Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors Methylphenidate, Placebo - ALL, Childhood, Leukemia, Lymphoblastic | Not applicable | Terminated | University of Minnesota | 1 | 2010-05-01 | 2015-03-27 |
| Genetically Modified Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia NK Cell Infusion - Lymphoblastic Leukemia, Acute | Phase 1 | Completed | St. Jude Children's Research Hospital | 14 | 2009-10-01 | 2017-04-26 |
| SCH 727965 in Patients With Acute Myelogenous Leukemia and Acute Lymphoblastic Leukemia (P04717AM2)(TERMINATED) SCH 727965, Gemtuzumab ozogamicin - Leukemia, Myeloid, Acute, Lymphoblastic Leukemia, Acute | Phase 2 | Terminated | Merck Sharp & Dohme LLC | 29 | 2009-01-01 | 2015-02-04 |
| Treatment of Adult Ph+ LAL With BMS-354825 Dasatinib - Lymphoblastic Leukemia, Acute | Phase 2 | Completed | Gruppo Italiano Malattie EMatologiche dell'Adulto | 53 | 2006-09-01 | 2017-01-04 |
| ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia R-Blocks, Protocol II-Ida - Lymphoblastic Leukemia, Acute, Lymphoma, Non-Hodgkin | Phase 4 | Completed | Charite University, Berlin, Germany | 338 | 2003-08-01 | 2013-02-04 |
| High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Cyclophosphamide, Daunorubicin, Vincristine - Lymphoblastic Leukemia, Acute | Phase 3 | Unknown | Japan Adult Leukemia Study Group | 240 | 2002-09-01 | 2008-11-14 |
| Applying Pediatric Regimens to Younger Adult Patients With Acute Lymphoblastic Leukemia (ALL) Methotrexate, Prednisolone, Dexamethasone - Lymphoblastic Leukemia, Acute | Phase 2 | Unknown | Japan Adult Leukemia Study Group | 120 | 2002-09-01 | 2008-11-14 |
| Therapy for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia Prednisone, Dexamethasone, Vincristine, Daunorubicin, Doxorubicin, L-asparaginase, PEG-L-asparaginase, Erwinia asparaginase, Methotrexate, Cyclophosphamide, Cytarabine, Etoposide - Lymphoblastic Leukemia, Acute | Phase 3 | Completed | St. Jude Children's Research Hospital | 501 | 2000-07-08 | 2020-09-11 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (12) · Recurrence (3) · Leukemia (2) · Brain Neoplasms (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, Non-Hodgkin (1) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (1)
Hematologic Diseases (12) · Hemic and Lymphatic Diseases (12) · Immune System Diseases (12) · Immunoproliferative Disorders (12) · Leukemia, Lymphoid (12) · Lymphatic Diseases (12) · Lymphoproliferative Disorders (12) · Neoplasms (12) · Neoplasms by Histologic Type (12) · Leukemia (10) · Disease Attributes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Brain Diseases (1) · Central Nervous System Diseases (1)
Vincristine (5) · Cytarabine (4) · Methotrexate (4) · Asparaginase (3) · Cyclophosphamide (3) · Dexamethasone (3) · Doxorubicin (3) · Mercaptopurine (3) · pegaspargase (3) · Daunorubicin (2) · Etoposide (2) · Hydrocortisone (2) · Prednisolone (2) · Prednisone (2) · Cortisone (1)
Japan Adult Leukemia Study Group (2) · St. Jude Children's Research Hospital (2) · Therapeutic Advances in Childhood Leukemia Consortium (2) · Charite University, Berlin, Germany (1) · Chongqing Peg-Bio Biopharm Co., Ltd. (1) · Gruppo Italiano Malattie EMatologiche dell'Adulto (1) · Merck Sharp & Dohme LLC (1) · University of Minnesota (1) · Versailles Hospital (1)
United States (5) · Australia (2) · Japan (2) · Canada (1) · China (1) · France (1) · Germany (1) · Italy (1)
Fumihiko Hayakawa, MD (2) · Tomoki Naoe, MD (2) · Alicia Kunin-Batson, Ph.D. (1) · Ching-Hon Pui, M.D. (1) · David Shook, MD (1) · Elizabeth Raetz, MD (1) · Liyan Miao (1) · William Carroll, MD (1)
PMID 14752084, PMID 15014526, PMID 15158091, PMID 15257960, PMID 21623761, PMID 21828124, PMID 21931113, PMID 21940824, PMID 23074282, PMID 23775972, PMID 23949430, PMID 24276047, PMID 25253770, PMID 26001791, PMID 28054442, PMID 31188727, PMID 31612640, PMID 31644328, PMID 34010787, PMID 34813516, PMID 38291722, PMID 38446568, PMID 39121442, PMID 39316653, PMID 39937083, PMID 40908865
F32CA141762 (1), P30CA021765 (1), R01CA113482 (1), R37CA036401 (1)