23 completed. 23 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 23 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 1 | Completed 1 |
Follow Liver Transplantation: new trials by email Literature Review of Liver Transplantation trials Research Report on Liver Transplantation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Diagnostic Validity of [18F]FSPG PET for the Assessment of Acute Rejection After Heart or Liver Transplantation [18F]FSPG - Graft Rejection, Heart Transplantation | Phase 2 | Completed | Asan Medical Center | 7 | 2020-11-18 | 2023-07-20 |
| Evaluate the Efficacy and Safety of 'Immuncell-LC' in Patients Undergoing Liver Transplantation Immuncell-LC - Liver Transplantation | Phase 1 / Phase 2 | Completed | GC Cell Corporation | 19 | 2019-01-24 | 2023-06-22 |
| Effect of Terlipressin on Cerebral Oxygen Saturation During Liver Transplantation Terlipressin, Normal saline - Terlipressin Adverse Reaction, Liver Transplantation | Phase 2 | Completed | Kasr El Aini Hospital | 30 | 2018-01-25 | 2018-12-24 |
| Efficacy of Low Dose, SubQ Interleukin-2 (IL-2) to Expand Endogenous Regulatory T-Cells in Liver Transplant Recipients Interleukin-2 - Liver Transplantation | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 6 | 2016-11-01 | 2026-01-13 |
| Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation Immunosuppression withdrawal - Liver Transplant, Liver Transplantation | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 100 | 2015-12-15 | 2023-09-14 |
| Extracorporeal Photopheresis in Liver Transplantation. Phase II Clinical Trial in Safety and Efficacy in Patients With Gradual Decrease of Immunosuppression. Extracorporeal Photopheresis Procedure (FEC) - Liver Transplantation, Immunosuppression | Phase 1 / Phase 2 | Completed | Red de Terapia Celular | 10 | 2013-04-01 | 2017-03-30 |
| Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients Immunosuppression withdrawal - Liver Transplant Recipients, Liver Transplantation | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 161 | 2012-08-14 | 2019-10-07 |
| A Study to Compare How the Body Absorbs and Processes Two Different Formulations of the Anti-rejection Medication Tacrolimus (Advagraf® or Prograf®) in Children Receiving an Organ Transplant, and How Safe and Effective They Are Over a Longer Period of Time Tacrolimus, Tacrolimus prolonged release - Heart Transplantation, Kidney Transplantation | Phase 2 | Completed | Astellas Pharma Europe Ltd. | 44 | 2012-04-03 | 2024-11-01 |
| Pharmacogenetic Trial of Tacrolimus After Pediatric Transplantation Tacrolimus - Heart Transplantation, Liver Transplantation | Phase 2 | Completed | The Hospital for Sick Children | 75 | 2011-09-01 | 2019-12-13 |
| Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf® Tacrolimus, Tacrolimus prolonged release - Intestine Transplantation, Kidney Transplantation | Phase 2 | Completed | Astellas Pharma Europe Ltd. | 81 | 2011-05-25 | 2026-10-19 |
| Efficacy, Safety, Tolerability, Pharmacokinetics of Sotrastaurin-tacrolimus vs. Mycophenolic Acid-tacrolimus in de Novo Liver Transplant Patients MMF(1000mg bid) + tacrolimus + standard of care medications, sotrastaurin (200mg bid) + tacrolimus + standard of care medications, sotrastaurin (300 mg bid) + tacrolimus + standard of care medications - Liver Transplantation | Phase 2 | Completed | Novartis Pharmaceuticals | 200 | 2010-04-01 | 2020-12-22 |
| Effect of Immunosuppression Drug Weaning on Hepatitis C Virus (HCV)-Induced Liver Damage After Liver Transplantation Gradual immunosuppression drug withdrawal. - Hepatitis C Virus Infection, Liver Transplantation | Phase 2 | Completed | Hospital Clinic of Barcelona | 34 | 2008-04-01 | 2013-12-20 |
| Adefovir Plus Vaccination in Transplant Patients Without Hepatitis B That Receive a Core Antibody Positive Liver Adefovir dipivoxil and hepatitis B vaccination - Hepatitis B, Liver Transplantation | Phase 1 / Phase 2 | Completed | Columbia University | 16 | 2006-03-01 | 2021-08-10 |
| Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation Zoledronic acid, Alendronate, Placebo Zoledronic Acid - Heart Transplantation, Liver Transplantation | Phase 2 / Phase 3 | Completed | Columbia University | 111 | 2005-11-01 | 2018-08-16 |
| Immune System Suppression With Alemtuzumab and Tacrolimus in Liver Transplantation Patients Alemtuzumab, Cyclosporine, Mycophenolate mofetil - Liver Disease, Liver Transplantation | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 27 | 2005-06-01 | 2012-12-27 |
| Comparing Efficacy and Safety of Tacrolimus With Steroids or Monoclonal Anti-IL2R Antibody in Hepatitis C Virus (HCV) Positive Liver Transplant Patients Tacrolimus, steroids, monoclonal anti-IL2R antibody - Hepatitis C, Liver Transplantation | Phase 2 | Completed | Astellas Pharma Inc | 138 | 2005-06-01 | 2013-04-11 |
| A Study of a Modified-Release Tacrolimus Based Immunosuppression Regimen in Stable Pediatric Liver Transplant Patients tacrolimus modified release (MR), tacrolimus - Liver Transplantation | Phase 2 | Completed | Astellas Pharma Inc | 19 | 2004-01-01 | 2013-10-17 |
| Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation IDN-6556, Placebo - Liver Transplantation, Hepatitis | Phase 2 | Completed | Conatus Pharmaceuticals Inc. | 99 | 2003-11-01 | 2012-08-10 |
| A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Liver Transplant Patients tacrolimus modified release (MR), tacrolimus - Liver Transplantation | Phase 2 | Completed | Astellas Pharma Inc | 70 | 2003-02-01 | 2013-09-30 |
| Sequential Therapy (FK506 + Monoclonal Anti-IL2R Antibodies + MMF) Versus FK506 With Steroids in Liver TX tacrolimus, Anti-IL2R AB, Mycophenolate mofetil - Liver Transplantation | Phase 2 | Completed | Astellas Pharma Inc | 94 | 2002-11-01 | 2014-08-26 |
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Carcinoma, Hepatocellular (2) · Hepatitis C (2) · Bone Resorption (1) · Cholestasis (1) · Hepatitis (1) · Hepatitis B (1) · Liver Diseases (1) · Rejection, Psychology (1)
Digestive System Diseases (6) · Liver Diseases (5) · Blood-Borne Infections (3) · Communicable Diseases (3) · Hepatitis (3) · Hepatitis, Viral, Human (3) · Infections (3) · Virus Diseases (3) · Adenocarcinoma (2) · Carcinoma (2) · Digestive System Neoplasms (2) · Flaviviridae Infections (2) · Liver Neoplasms (2) · Neoplasms (2) · Neoplasms by Histologic Type (2)
Tacrolimus (9) · Mycophenolic Acid (2) · Steroids (2) · 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide (1) · 3-(2-(2-tert-butylphenylaminooxalyl)aminopropionylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (1) · 4-(3-fluoropropyl)glutamic acid (1) · Alemtuzumab (1) · Alendronate (1) · BID protein, human (1) · Celsior (1) · Cyclosporine (1) · Daclizumab (1) · FEC protocol (1) · Genetic Therapy (1) · Interleukin-2 (1)
Astellas Pharma Inc (5) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Astellas Pharma Europe Ltd. (2) · Columbia University (2) · Asan Medical Center (1) · Beijing Chao Yang Hospital (1) · Beth Israel Deaconess Medical Center (1) · Conatus Pharmaceuticals Inc. (1) · GC Cell Corporation (1) · Hospital Clinic of Barcelona (1) · Kasr El Aini Hospital (1) · Novartis Pharmaceuticals (1) · Red de Terapia Celular (1) · Rennes University Hospital (1) · The Hospital for Sick Children (1)
United States (10) · France (6) · Italy (6) · Canada (5) · Czechia (5) · Germany (5) · Spain (5) · United Kingdom (4) · Belgium (3) · Poland (3) · Austria (2) · South Korea (2) · Switzerland (2) · Argentina (1) · China (1)
Alberto Sanchez-Fueyo, MD (1) · Dae Hyuk Moon, MD (1) · Ding Ma, M.D. (1) · Elizabeth Shane, M.D. (1) · Eric Bellissant, MD, PhD (1) · Giuseppe Tisone, MD (1) · J Bucuvalas, M.D. (1) · J. Richard Thistlethwaite, MD (1) · James F. Markmann, MD, PhD (1) · Karim Boudjema, MD, PhD (1) · Kyung Suk Suh, MD (1) · Marina Berenguer, MD (1)
PMID 23024190, PMID 25677074, PMID 26729653, PMID 30178515, PMID 32786149, PMID 33280227, PMID 35819312
U01AI100807 (1)