2 completed, 2 recruiting, 1 active not recruiting, 1 terminated. 2 Phase 3, 1 Not applicable, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 2 | Recruiting 2 |
| Not applicable | 1 | Terminated 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Leukocyte Adhesion Deficiency: new trials by email Literature Review of Leukocyte Adhesion Deficiency trials Research Report on Leukocyte Adhesion Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Extension Study Assessing the Safety and Efficacy of AVTX-803 in Subjects With Leukocyte Adhesion Deficiency Type II AVTX-803 - Leukocyte Adhesion Deficiency | Phase 3 | Recruiting | AUG Therapeutics | 2 | 2023-04-10 | 2026-05-01 |
| A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II AVTX-803 (L-Fucose) - Leukocyte Adhesion Deficiency | Phase 3 | Recruiting | AUG Therapeutics | 4 | 2022-07-28 | 2026-05-01 |
| Long-Term Follow-Up (LTFU) for Gene Therapy of Leukocyte Adhesion Deficiency-I (LAD-I) Leukocyte Adhesion Deficiency | Active not recruiting | Rocket Pharmaceuticals Inc. | 9 | 2022-03-09 | 2025-12-18 | |
| Bone Marrow Transplant With Abatacept for Non-Malignant Diseases Abatacept - Hurler Syndrome, Fanconi Anemia | Phase 1 | Completed | Emory University | 10 | 2014-01-01 | 2019-12-26 |
| Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) Hematopoietic Stem Cell Transplant - Hemophagocytic Lymphohistiocytosis, Chronic Active Epstein-Barr Virus Infection | Phase 2 | Completed | Medical College of Wisconsin | 47 | 2013-12-01 | 2022-12-08 |
| Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation Alefacept - Thalassemia, Sickle Cell Disease | Not applicable | Terminated | Emory University | 3 | 2010-09-01 | 2017-07-27 |
Leukocyte adhesion deficiency type 1 (6) · Granulomatous Disease, Chronic (3) · Anemia, Aplastic (2) · Anemia, Diamond-Blackfan (2) · Anemia, Sickle Cell (2) · Chediak-Higashi Syndrome (2) · Dyskeratosis Congenita (2) · Fanconi Anemia (2) · Lymphohistiocytosis, Hemophagocytic (2) · Neutropenia, Severe Congenital, Autosomal Recessive 3 (2) · Shwachman-Diamond Syndrome (2) · Thrombasthenia (2) · Wiskott-Aldrich Syndrome (2) · Hyper-IgM Immunodeficiency Syndrome (1) · Mucopolysaccharidosis I (1)
Chronic Disease (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Disease Attributes (3) · Genetic Diseases, Inborn (3) · Genetic Diseases, X-Linked (3) · Hematologic Diseases (3) · Hemic and Lymphatic Diseases (3) · Immune System Diseases (3) · Immunologic Deficiency Syndromes (3) · Leukocyte Disorders (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Phagocyte Bactericidal Dysfunction (3) · Primary Immunodeficiency Diseases (3) · Albinism (2)
Abatacept (1) · Alefacept (1) · Fucose (1) · Stem Cell Transplantation (1)
AUG Therapeutics (2) · Emory University (2) · Medical College of Wisconsin (1) · Rocket Pharmaceuticals Inc. (1)
United States (6) · Canada (1) · Spain (1) · United Kingdom (1)
Claire Booth, MBBS, PhD, MSc (1) · David Deyle (1) · David Deyle, MD (1) · Donald Kohn, MD (1) · John Horan, MD (1) · John T Horan, MD (1) · Julian Sevilla, MD, PhD (1) · Mary Horowitz, MD, MS (1)
PMID 26095669, PMID 37042921, PMID 40305711
U10HL069294 (1), U24CA076518 (1)