7 completed, 4 recruiting, 1 active not recruiting, 1 not yet recruiting. 5 Phase 2, 3 Not applicable, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Not applicable | 3 | Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 1 | 3 | Completed 2, Withdrawn 1 |
| Phase 3 | 2 | Recruiting 2 |
Follow Leukocyte adhesion deficiency type 1: new trials by email Literature Review of Leukocyte adhesion deficiency type 1 trials Research Report on Leukocyte adhesion deficiency type 1
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reconstruction of Diffusely Diseased Left Anterior Descending with Left Internal Mammary Artery On-lay Patch or Saphenous Vein Patch Without Endarterectomy by Opening the Whole Wall of the Diseased Segment(s) Has Less Risk and Fewer Complications Compared to Endarterectomy Technique CABG, LIMA on lay patch, Safenous vein patch - LAD (Left Anterior Descending) Coronary Artery Stenosis | Not applicable | Not yet recruiting | Assiut University | 90 | 2025-12-10 | 2025-02-19 |
| Comparison of Bidirectional Palpation Test and Transit Time Flow Measurement for LIMA-LAD Graft Patency Coronary Arterial Disease (CAD), Coronary Artery Bypass | Completed | Abdulgani Orhun YENİGÜN | 116 | 2023-08-31 | 2025-07-08 | |
| An Extension Study Assessing the Safety and Efficacy of AVTX-803 in Subjects With Leukocyte Adhesion Deficiency Type II AVTX-803 - Leukocyte Adhesion Deficiency | Phase 3 | Recruiting | AUG Therapeutics | 2 | 2023-04-10 | 2026-05-01 |
| 4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy Respiratory gating - Breast Cancer, Radiation-Induced Vascular Disease | Not applicable | Unknown | Central Hospital Saint Quentin | 15 | 2023-03-02 | 2023-06-09 |
| A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II AVTX-803 (L-Fucose) - Leukocyte Adhesion Deficiency | Phase 3 | Recruiting | AUG Therapeutics | 4 | 2022-07-28 | 2026-05-01 |
| Long-Term Follow-Up (LTFU) for Gene Therapy of Leukocyte Adhesion Deficiency-I (LAD-I) Leukocyte Adhesion Deficiency | Active not recruiting | Rocket Pharmaceuticals Inc. | 9 | 2022-03-09 | 2025-12-18 | |
| Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC data collection - Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes | Recruiting | Paul Szabolcs | 50 | 2020-08-20 | 2026-01-13 | |
| A Clinical Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I RP-L201 - Leukocyte Adhesion Defect - Type I | Phase 1 / Phase 2 | Completed | Rocket Pharmaceuticals Inc. | 9 | 2019-08-30 | 2023-11-15 |
| A Gene Therapy Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I RP-L201 - Leukocyte Adhesion Defect - Type I | Phase 1 | Withdrawn | Rocket Pharmaceuticals Inc. | 2019-04-15 | 2021-12-07 | |
| Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT Hydroxyurea, Alemtuzumab, Fludarabine - Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes | Phase 2 | Recruiting | Paul Szabolcs | 100 | 2014-02-04 | 2025-12-15 |
| Bone Marrow Transplant With Abatacept for Non-Malignant Diseases Abatacept - Hurler Syndrome, Fanconi Anemia | Phase 1 | Completed | Emory University | 10 | 2014-01-01 | 2019-12-26 |
| Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) Hematopoietic Stem Cell Transplant - Hemophagocytic Lymphohistiocytosis, Chronic Active Epstein-Barr Virus Infection | Phase 2 | Completed | Medical College of Wisconsin | 47 | 2013-12-01 | 2022-12-08 |
| Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation Alefacept - Thalassemia, Sickle Cell Disease | Not applicable | Terminated | Emory University | 3 | 2010-09-01 | 2017-07-27 |
| Stem Cell Transplantation to Treat Leukocyte Adhesion Deficiency modified stem cell transplant - Leukocyte-Adhesion Deficiency Syndrome | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 10 | 2002-02-01 | 2008-03-04 |
| Gene Therapy for Patients With Leukocyte Adherence Deficiency (Follow-Up of Phase 1 Trial) Leukocyte Adhesion Deficiency Syndrome | Completed | National Cancer Institute (NCI) | 2 | 2001-08-15 | 2017-07-02 | |
| Interferon Gamma to Treat Leukocyte Adhesion Deficiency Type I Interferon gamma - Leukocyte Adhesion Deficiency Syndrome | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 5 | 1999-04-01 | 2008-03-04 |
Granulomatous Disease, Chronic (5) · Anemia, Diamond-Blackfan (4) · Anemia, Sickle Cell (4) · Chediak-Higashi Syndrome (4) · Lymphohistiocytosis, Hemophagocytic (4) · Wiskott-Aldrich Syndrome (4) · Coronary Stenosis (3) · Dyskeratosis Congenita (3) · Leukocyte-Adhesion Deficiency Syndrome (3) · Mucopolysaccharidosis I (3) · beta-Thalassemia (3) · Adrenoleukodystrophy (2) · Anemia, Aplastic (2) · Autoimmune Lymphoproliferative Syndrome (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Genetic Diseases, Inborn (8) · Immune System Diseases (8) · Immunologic Deficiency Syndromes (6) · Primary Immunodeficiency Diseases (6) · Chronic Disease (5) · Disease Attributes (5) · Genetic Diseases, X-Linked (5) · Hematologic Diseases (5) · Hemic and Lymphatic Diseases (5) · Leukocyte Disorders (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Phagocyte Bactericidal Dysfunction (5) · Skin and Connective Tissue Diseases (5)
Abatacept (1) · Alefacept (1) · Alemtuzumab (1) · Data Collection (1) · Fucose (1) · Hydroxyurea (1) · Interferon-gamma (1) · Melphalan (1) · Stem Cell Transplantation (1) · Thiotepa (1) · fludarabine (1) · fludarabine phosphate (1)
Rocket Pharmaceuticals Inc. (3) · AUG Therapeutics (2) · Emory University (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Paul Szabolcs (2) · Abdulgani Orhun YENİGÜN (1) · Assiut University (1) · Central Hospital Saint Quentin (1) · Medical College of Wisconsin (1) · National Cancer Institute (NCI) (1)
United States (12) · Spain (3) · United Kingdom (2) · Canada (1) · France (1) · Turkey (Türkiye) (1)
Claire Booth, MBBS, PhD, MSc (2) · Paul Szabolcs, MD (2) · David Deyle (1) · David Deyle, MD (1) · Donald B Kohn, MD (1) · Donald Kohn, MD (1) · John Horan, MD (1) · John T Horan, MD (1) · Julian Sevilla, MD, PhD (1) · Mary Horowitz, MD, MS (1)
PMID 40305711, PMID 26095669, PMID 32634238, PMID 32750127, PMID 37042921
U10HL069294 (1), U24CA076518 (1)