5 completed, 3 recruiting, 2 unknown. 4 Not applicable, 3 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Recruiting 3, Completed 1 |
| Phase 2 | 3 | Unknown 2, Completed 1 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Leber Hereditary Optic Neuropathy: new trials by email Literature Review of Leber Hereditary Optic Neuropathy trials Research Report on Leber Hereditary Optic Neuropathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metabolomics Analysis According to the Retinal Nerve Fiber Layer in Patients With NOHL Mutations (MétabOCT) Optical coherent tomography - Healthy Subjects, Leber Hereditary Optic Neuropathy | Not applicable | Recruiting | Hôpital Necker-Enfants Malades | 90 | 2023-03-10 | 2025-11-18 |
| New Non-invasive Modalities for Assessing Retinal Structure and Function LSFG-NAVI - Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion | Not applicable | Recruiting | Randy Kardon | 500 | 2019-05-06 | 2026-09-08 |
| Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year GS010, Placebo - Leber Hereditary Optic Neuropathy | Phase 3 | Completed | GenSight Biologics | 98 | 2018-03-12 | 2026-04-16 |
| RESCUE and REVERSE Long-term Follow-up GS010, Sham Intravitreal Injection - Leber Hereditary Optic Neuropathy | Phase 3 | Completed | GenSight Biologics | 62 | 2018-01-09 | 2026-03-02 |
| REALITY LHON Registry Patient-reported outcomes (PROs) - Leber Hereditary Optic Neuropathy | Completed | GenSight Biologics | 44 | 2018-01-03 | 2026-03-02 | |
| A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy rAAV2-ND4 - Leber Hereditary Optic Neuropathy | Phase 2 / Phase 3 | Unknown | Huazhong University of Science and Technology | 159 | 2017-12-27 | 2020-09-17 |
| Stem Cell Ophthalmology Treatment Study II Arm 1 - Retinal Disease, Age-Related Macular Degeneration | Not applicable | Recruiting | MD Stem Cells | 500 | 2016-01-01 | 2026-06-29 |
| Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients GS010 - Leber Hereditary Optic Neuropathy | Phase 1 / Phase 2 | Completed | GenSight Biologics | 19 | 2014-02-13 | 2026-03-02 |
| Trial of Cyclosporine in the Acute Phase of Leber Hereditary Optic Neuropathy cyclosporine - Leber Hereditary Optic Neuropathy | Phase 2 | Unknown | University Hospital, Angers | 12 | 2011-07-01 | 2014-06-27 |
| Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON) rAAV2-ND4 - Leber Hereditary Optic Neuropathy | Not applicable | Completed | Bin Li | 9 | 2011-04-01 | 2018-01-31 |
Optic Atrophy, Hereditary, Leber (10) · Eye Diseases (4) · Eye Diseases, Hereditary (3) · Mitochondrial Diseases (3) · Genetic Diseases, Inborn (2) · Nervous System Diseases (2) · Neurodegenerative Diseases (2) · Optic Nerve Diseases (2) · Optic Neuropathy, Ischemic (2) · Retinal Diseases (2) · Acute zonal occult outer retinopathy (1) · Blindness (1) · Cone Dystrophy (1) · Cone-Rod Dystrophies (1) · Doyne honeycomb retinal dystrophy (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Cranial Nerve Diseases (10) · Heredodegenerative Disorders, Nervous System (10) · Metabolic Diseases (10) · Nutritional and Metabolic Diseases (10) · Optic Atrophies, Hereditary (9) · Optic Atrophy (9) · Genetic Diseases, Inborn (8) · Nervous System Diseases (8) · Neurodegenerative Diseases (8) · Optic Nerve Diseases (8) · Eye Diseases, Hereditary (7) · Mitochondrial Diseases (7) · Eye Diseases (6) · Cardiovascular Diseases (2)
Cyclosporine (1) · Patient Reported Outcome Measures (1) · salicylhydroxamic acid (1)
GenSight Biologics (4) · Bin Li (1) · Huazhong University of Science and Technology (1) · Hôpital Necker-Enfants Malades (1) · MD Stem Cells (1) · Randy Kardon (1) · University Hospital, Angers (1)
France (6) · United States (5) · Italy (3) · United Kingdom (3) · China (2) · Spain (2) · Austria (1) · Belgium (1) · Germany (1) · Taiwan (1) · United Arab Emirates (1)
Nancy Newman, MD (2) · Bin Li, PhD,MD (1) · Christophe Orssaud, MD (1) · Jeffrey Weiss, MD (1) · Patrick Yu-Wai-Man, PhD (1) · Randy H Kardon, MD, PhD (1) · Steven Levy, MD (1) · Yong Zhang, PhD,MD (1) · bin Li, PhD,MD (1)
PMID 36449262, PMID 26892229, PMID 34108929, PMID 1463007, PMID 1674640, PMID 18441370, PMID 18441371, PMID 18774912, PMID 1928099, PMID 22612072, PMID 22644094, PMID 23063736, PMID 24396955, PMID 25950380, PMID 26199618, PMID 26604914, PMID 26606867, PMID 27386292, PMID 27426279, PMID 27749593, PMID 27857759, PMID 27904503, PMID 29270420, PMID 29454364, PMID 30050918, PMID 30878986, PMID 31119146, PMID 31237206, PMID 31620478, PMID 3201231, PMID 32039263, PMID 32231088, PMID 33546345, PMID 39699886, PMID 5063796
2017 (2)