333 completed, 17 recruiting, 13 unknown, 13 withdrawn. 395 Phase 1, 108 Phase 2.
Follow Influenza, Human: new trials by email Literature Review of Influenza, Human trials Research Report on Influenza, Human
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating AVM0703 for Treatment of COVID-19 or Influenza-mediated ARDS AVM0703, Placebo - ARDS, Covid19 | Phase 1 | Not yet recruiting | AVM Biotechnology Inc | 16 | 2026-12-01 | 2025-10-02 |
| Safety and Immunogenicity of Chimeric Hemagglutinin mRNA Vaccine Candidates cH15/3, cH4/3, cH5/1N1 - Influenza | Phase 1 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 60 | 2026-10-09 | 2026-10-30 |
| A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1010 in Healthy Children mRNA-1010, Fluarix Trivalent - Seasonal Influenza | Phase 1 | Recruiting | ModernaTX, Inc. | 96 | 2026-10-07 | 2026-10-28 |
| Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above. Flu H5 egg pandemic low dose vaccine, with adjuvant, Flu H5 Egg Pandemic medium dose vaccine, with adjuvant, Flu H5 Egg Pandemic high dose vaccine, with adjuvant - Healthy Volunteers, Influenza | Phase 1 / Phase 2 | Recruiting | Sanofi | 640 | 2026-08-03 | 2026-09-15 |
| H1ssF Flu Vaccine Clinical Trial H1ssF vaccine, Flucelvax seasonal vaccine - Influenza | Phase 1 | Withdrawn | University of Minnesota | 2026-08-01 | 2026-09-21 | |
| A Study to Evaluate the Intratumoral Influenza Vaccine Administration in Patients With Breast Cancer Fluzone Quadrivalent - Breast Cancer, Breast Cancer Triple Negative | Phase 1 | Withdrawn | Rush University Medical Center | 2026-06-01 | 2026-03-11 | |
| Establishing a Controlled Human Infection Model for Influenza H3N2 as a Foundation for Pandemic Preparedness Intranasal inoculation of RG-A/Texas/71/2017 (H3N2) influenza in each naris on Day 1 of the study. - Influenza (Healthy Volunteers) | Phase 1 | Recruiting | Dalhousie University | 32 | 2026-06-01 | 2026-08-27 |
| Rechallenge With a Low Pathogenicity Avian H10N7 Influenza Virus in Healthy Human Volunteers Previously Challenged With H10N7 Influenza A/Mallard/Ohio-99/MM4/1989 H10N7 - Influenza Infection, Infections | Phase 1 | Enrolling by invitation | National Institute of Allergy and Infectious Diseases (NIAID) | 33 | 2026-04-21 | 2026-10-15 |
| Study of Different Formulations of Vaccines Encoding the RSV Monovalent Antigen or the Flu H5 Antigen in Participants 18 to 49 Years of Age H5 Flu Investigational Medical Product (IMP) 1, H5 Flu IMP 2, H5 Flu IMP 3 - Respiratory Syncytial Virus (RSV), Influenza A(H5N1) | Phase 1 | Recruiting | Sanofi | 570 | 2026-04-15 | 2026-05-08 |
| Study of TRX-100 Evaluating the Safety, Pharmacokinetics, and Food Effect in Healthy Volunteers TRX-100, Placebo - Healthy Volunteer | Phase 1 | Recruiting | Traws Pharma, Inc. | 32 | 2026-03-25 | 2026-08-03 |
| A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults Investigational mRNA Seasonal Flu/COVID-19 Combination (Flu/COVm) Vaccine, Licensed Seasonal Influenza Vaccine, Licensed COVID-19 Vaccine - Influenza, Human+COVID-19 | Phase 1 | Recruiting | GlaxoSmithKline | 225 | 2026-03-09 | 2026-06-30 |
| Phase 1/2 Study of a Plant-Based Seasonal Recombinant Trivalent VLP Influenza Vaccine Recombinant Influenza vaccine candidate, Commercial Influenza vaccine - Influenza | Phase 1 / Phase 2 | Active not recruiting | Aramis Biotechnologies Inc. | 728 | 2026-02-25 | 2026-08-04 |
| A Phase I Trial to Evaluate the Safety and Immunogenicity of Influenza Virus Split Vaccine (Adjuvant) influenza vaccine（BK01 adjuvnat）, approved influenza vaccine, adjuvant placebo - Influenza | Phase 1 | Not yet recruiting | Changchun BCHT Biotechnology Co. | 160 | 2026-02-07 | 2026-01-16 |
| A Clinical Trial of Influenza Virus Split Vaccine for Individuals Aged 60 Years and Above Influenza virus split vaccine (0.7mL/vial), Influenza virus split vaccine, Phosphate buffer solution (PBS) - Influenza | Phase 1 | Recruiting | Shanghai Institute Of Biological Products | 120 | 2025-12-16 | 2026-01-14 |
| Clinical Trial of Subunit Influenza Vaccine (Adjuvant) in Chinese Population Aged 65 Years and Older Subunit Influenza Vaccine (Adjuvant), MF59, 0.9% sodium chloride injection (normal saline) - Influenza, Influenza Vaccine | Phase 1 | Active not recruiting | Ab&B Bio-tech Co., Ltd.JS | 80 | 2025-11-13 | 2026-02-19 |
| Clinical Trial of Quadrivalent Subunit Influenza Vaccine (Adjuvant) in Chinese Population Aged 65 Years and Older Quadrivalent Subunit Influenza Vaccine (Adjuvant), MF59, 0.9% sodium chloride injection (normal saline) - Influenza, Influenza Vaccine | Phase 1 | Active not recruiting | Ab&B Bio-tech Co., Ltd.JS | 80 | 2025-11-13 | 2026-02-19 |
| A Trial to Evaluate the Effect of CD388/MK1406 on the Immunogenicity of Fluzone® HD Vaccine (CD388.SQ.1.08/MK-1406-007) Fluzone® High-Dose (HD) influenza vaccine, MK-1406 Injection, Placebo - Healthy Participants | Phase 1 | Active not recruiting | Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 710 | 2025-11-08 | 2026-10-16 |
| First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics Placebo for VNT-101, VNT-101 - Influenza | Phase 1 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 78 | 2025-09-16 | 2026-05-11 |
| pH1N1 Blinded Challenge Study A/Arkansas/08/2020 (pH1N1), Sham/Diluent (1X SPG+Arg+Gel) - Influenza | Phase 1 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 90 | 2025-09-10 | 2026-10-16 |
| Phase I Clinical Trial of Influenza Vaccine (Split Virion), Inactivated (High Dose) Influenza Vaccine (Split Virion), Inactivated (High Dose), Influenza Vaccine (Split Virion), Inactivated - Influenza | Phase 1 | Completed | Sinovac Biotech Co., Ltd | 50 | 2025-08-21 | 2026-09-23 |
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PMID 26432909, PMID 19540952, PMID 21906647, PMID 22542645, PMID 26042486, PMID 26275339, PMID 26391974, PMID 30953061, PMID 31079849, PMID 33529172, PMID 39369576, PMID 16571878, PMID 16980114, PMID 17029131, PMID 17707753, PMID 18260764, PMID 18301743, PMID 18550874, PMID 18599164, PMID 18694338, PMID 18808338, PMID 19210163, PMID 19464558, PMID 19577636, PMID 19716456, PMID 19745215, PMID 19773098, PMID 20423222, PMID 20581690, PMID 20969925, PMID 21203437, PMID 21203523, PMID 21285968, PMID 21377509, PMID 21496468, PMID 21846636, PMID 21864624, PMID 21930881, PMID 21945258, PMID 21949042, PMID 21975270, PMID 22318394, PMID 22426371, PMID 22551811, PMID 22575166, PMID 22796139, PMID 22846396, PMID 22891287, PMID 23118984, PMID 23230059
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