3 completed, 3 recruiting, 2 terminated, 1 active not recruiting. 1 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 1 | Unknown 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Hypothalamic Amenorrhea: new trials by email Literature Review of Hypothalamic Amenorrhea trials Research Report on Hypothalamic Amenorrhea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 20 | 2025-12-09 | 2026-07-13 |
| The REgistry of Very Early Estrogen and AnovuLation Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24), REVEAL Questionnaire - Hypothalamic Amenorrhea, Functional, Hypothalamic Amenorrhea | Recruiting | Mayo Clinic | 100000 | 2024-07-01 | 2025-11-21 | |
| Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health (ARCH) Hypothalamic Amenorrhea | Active not recruiting | Mayo Clinic | 90 | 2023-01-17 | 2026-06-04 | |
| Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders Kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 1 | Completed | Stephanie B. Seminara, MD | 13 | 2022-12-16 | 2025-10-03 |
| Body Fat as Determinant of Female Gonadal Dysfunction Anthropometric and physical examination, Indirect calorimetry, accelerometer and seven-day dietary recall, Biochemical, hormonal and metabolic phenotyping - Polycystic Ovary Syndrome, Hypothalamic Amenorrhea | Completed | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 50 | 2020-01-31 | 2026-09-16 | |
| Total Antioxidant Capacity Before and After HRT in Hypotalamic Amenorrhea 1 mg of transdermal estradiol daily and 10mg of oral MPA - Hypothalamic Amenorrhea | Not applicable | Unknown | Catholic University of the Sacred Heart | 20 | 2015-03-01 | 2016-12-07 |
| Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate Kallmann Syndrome, Hypogonadotropic Hypogonadism | Recruiting | Centre Hospitalier Universitaire Vaudois | 2000 | 2012-03-01 | 2022-06-21 | |
| Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency Disorders Idiopathic Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea | Terminated | Massachusetts General Hospital | 50 | 2010-06-01 | 2011-05-24 | |
| The Luveris In Vitro Fertilization Trial Luveris fixed dose, Luveris increasing dose - Infertility, Hypothalamic Amenorrhea | Phase 4 | Terminated | University Reproductive Associates | 14 | 2009-04-01 | 2018-08-07 |
| Hormone Dynamics and Bone Mineral Density in Anorexia Nervosa v. Hypothalamic Amenorrhea Anorexia Nervosa, Hypothalamic Amenorrhea | Completed | Massachusetts General Hospital | 61 | 2006-03-01 | 2020-09-02 |
Hypogonadism (3) · Amenorrhea (2) · Infertility (2) · Motor Activity (2) · Polycystic Ovary Syndrome (2) · Anorexia Nervosa (1) · Anosmia (1) · Anovulation (1) · Body Weight (1) · Bone Diseases, Metabolic (1) · Cleft Lip (1) · Cleft Palate (1) · Cryptorchidism (1) · Depression (1) · Hyperandrogenism (1)
Endocrine System Diseases (6) · Gonadal Disorders (5) · Genital Diseases (4) · Urogenital Diseases (4) · Adnexal Diseases (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Genital Diseases, Female (3) · Ovarian Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Behavior (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Cysts (2) · Disorders of Sex Development (2)
Blood Pressure Monitoring, Ambulatory (1) · Luteinizing Hormone, beta Subunit (1) · Physical Examination (1)
Massachusetts General Hospital (2) · Mayo Clinic (2) · Stephanie B. Seminara, MD (2) · Catholic University of the Sacred Heart (1) · Centre Hospitalier Universitaire Vaudois (1) · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal (1) · University Reproductive Associates (1)
United States (7) · Italy (1) · Spain (1) · Switzerland (1)
Chrisandra Shufelt, MD (2) · Anne A Klibanski, MD (1) · David B Herzog, MD (1) · Elizabeth A Lawson, MD (1) · Erinne M Meenaghan, NP (1) · Karen K Miller, MD (1) · Nelly Pitteloud, M.D. (1) · Stephanie Seminara, MD (1)
PMID 23643382, PMID 25394172, PMID 42359269
R01HD106096 (1), R37HD043341 (1)