4 completed, 2 unknown, 1 recruiting, 1 terminated. 8 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 4, Unknown 2, Recruiting 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow GVHD: new trials by email Literature Review of GVHD trials Research Report on GVHD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase III Study Comparing GVHD Prophylaxis With ATG-thymoglobulin to ATLG-grafalon in Elderly Patients With Acute Myeloid Leukemia or Myelodysplasic Syndrome and Receiving an Allogeneic Hematopoietic Stem Cell Transplantation With a 10/10 HLA Matched Unrelated Donor Grafalon, Thymoglobulin - GVHD | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 324 | 2023-11-28 | 2026-04-27 |
| Comparison of Different Dose of Post-transplantation Cyclophosphamide as Graft Versus Host Disease Prophylaxis PTCY - GVHD | Phase 3 | Unknown | Shanghai Jiao Tong University School of Medicine | 138 | 2023-10-01 | 2023-08-21 |
| Effect of PMSCs and Their Secretome for the Treatment of GvHD Secretome (set of substances released from the cell to its surroundings) of mesenchymal stem cells retrieved from the placenta (containing 400 microgram protein/ milliliter), 4 cc distilled water dissolved in albumin 20% - GVHD | Phase 3 | Completed | Tabriz University of Medical Sciences | 60 | 2023-01-01 | 2024-06-21 |
| A Study of Itolizumab in Combination With Corticosteroids for the First-Line Treatment of Acute Graft Versus Host Disease (EQUATOR) Itolizumab, EQ001 Placebo - Graft Versus Host Disease, GVHD | Phase 3 | Terminated | Equillium | 158 | 2022-04-29 | 2025-06-17 |
| Outcomes of Patients After Allo-HSCT With Decitabine and NAC decitabine, Acetylcysteine, Semustine - Engraft Failure, Relapse | Phase 3 | Unknown | The First Affiliated Hospital of Soochow University | 100 | 2021-07-01 | 2021-06-30 |
| CD45RA Depleted T-cell Infusion for Prevention of Infections After TCRab/CD19-depleted Allo-HSCT CD45RA-depleted peripheral blood mononuclear cells - Leukemia, Lymphoma | Phase 2 / Phase 3 | Completed | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 150 | 2016-10-01 | 2023-03-16 |
| Comparison of Two Automated Mononuclear Collection Systems in Patients Undergoing Extracorporeal Photochemotherapy. A Cross-over Equivalence Study. (MNC_CMNC) Spectra Optia - GvHD, Lung Graft Dysfunction | Phase 3 | Completed | Fondazione IRCCS Policlinico San Matteo di Pavia | 51 | 2015-08-01 | 2016-01-11 |
| Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD) US-ATG-F, Placebo - GVHD, Adult Acute Myeloid Leukemia | Phase 3 | Completed | Neovii Biotech | 260 | 2011-10-10 | 2019-04-09 |
Graft vs Host Disease (4) · Myelodysplastic Syndromes (2) · Anemia, Refractory, with Excess of Blasts (1) · Leukemia (1) · Leukemia, Myeloid, Acute (1) · Lymphoma (1) · Opportunistic Infections (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Recurrence (1)
Immune System Diseases (5) · Bone Marrow Diseases (2) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Immunoproliferative Disorders (2) · Lymphatic Diseases (2) · Lymphoproliferative Disorders (2) · Neoplasms (2) · Neoplasms by Histologic Type (2) · Anemia (1) · Anemia, Refractory (1) · Disease Attributes (1) · Infections (1) · Leukemia (1) · Leukemia, Lymphoid (1)
thymoglobulin (2) · Acetylcysteine (1) · Antilymphocyte Serum (1) · Busulfan (1) · Cyclophosphamide (1) · Cyclosporine (1) · Cytarabine (1) · Decitabine (1) · Mycophenolic Acid (1) · Secretome (1) · Semustine (1) · itolizumab (1)
Assistance Publique - Hôpitaux de Paris (1) · Equillium (1) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Neovii Biotech (1) · Shanghai Jiao Tong University School of Medicine (1) · Tabriz University of Medical Sciences (1) · The First Affiliated Hospital of Soochow University (1)
Australia (2) · France (2) · Italy (2) · United States (2) · Belgium (1) · Canada (1) · China (1) · Germany (1) · Iran (1) · Israel (1) · New Zealand (1) · Portugal (1) · Russia (1) · South Korea (1) · Spain (1)
Anne Kuan (1) · Babak Nejati, MD (1) · Graciela Pavon-Djavid, PhD (1) · Hossein Ghasemi Moghadam, MD (1) · Larisa Shelikhova, PhD (1) · Michael Maschan, PhD (1) · Sepideh Zununi Vahed, PhD (1) · Yue Han, Prof. (1)