5 unknown, 3 recruiting, 2 completed, 1 active not recruiting. 4 Phase 3, 3 Phase 2, 2 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 2, Active not recruiting 1, Unknown 1 |
| Phase 2 | 3 | Unknown 3 |
| Not applicable | 2 | Recruiting 1, Unknown 1 |
| Phase 1 | 2 | Recruiting 2 |
Follow Semustine: new trials by email Literature Review of Semustine trials Research Report on Semustine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Venetoclax-Enhanced BUCY vs. Standard BUCY Conditioning in High-Risk AML and MDS Patients Undergoing Allo-HSCT (Ven-BUCY Study) Venetoclax, None-placebo, Busulfan (BU) - Acute Myeloid Leukemia, High-Risk Acute Myeloid Leukemia | Not applicable | Recruiting | First Affiliated Hospital of Zhejiang University | 138 | 2025-08-20 | 2026-09-02 |
| Study on the Efficacy and Safety of MA-BUCY2 Conditioning in High-risk AML Patients Underwent Haplo-HSCT MA-BUCY2, BUCY2 - Haploidentical Stem Cell Transplantation, Conditioning | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 264 | 2023-04-15 | 2023-04-18 |
| Human Leukocyte Antigen (HLA) Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Busulfan (Busulfex), Cyclophosphamide (CTX), Fludarabine (Fludara) - Hematologic Disease | Phase 1 | Recruiting | He Huang | 29 | 2022-08-04 | 2026-06-09 |
| Human Leukocyte Antigen (HLA) Mismatched Related Allogeneic Hematopoietic Stem Cell Transplantation Busulfan (Busulfex), Cyclophosphamide (CTX), Fludarabine (Fludara) - Hematologic Diseases | Phase 1 | Recruiting | He Huang | 29 | 2022-08-04 | 2025-02-05 |
| Outcomes of Patients After Allo-HSCT With Decitabine and NAC decitabine, Acetylcysteine, Semustine - Engraft Failure, Relapse | Phase 3 | Unknown | The First Affiliated Hospital of Soochow University | 100 | 2021-07-01 | 2021-06-30 |
| A Single-arm Trial of Prophylactic Tocilizumab for Acute GVHD Prevention After Haploidentical HSCT. Cytarabine, Busulfan, Cyclophosphamide - Leukemia, Graft-versus-host-disease | Phase 2 | Unknown | Yi Luo | 46 | 2020-12-03 | 2023-02-21 |
| A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies Cytarabine, Busulfan, Cyclophosphamide - Leukemia, MDS | Phase 3 | Active not recruiting | First Affiliated Hospital of Zhejiang University | 232 | 2020-09-01 | 2026-04-09 |
| RIC Regimen for Elderly or High Comorbidity Burden Patients Receiving Haplo-HSCT Cytarabine - Acute Leukemia, Myelodysplastic Syndromes | Phase 2 | Unknown | Peking University People's Hospital | 50 | 2018-02-01 | 2024-03-26 |
| RIC Regimen for Low- and Intermediate-risk MDS Receiving Haplo-HSCT Cytarabine - Myelodysplastic Syndromes | Phase 2 | Unknown | Peking University People's Hospital | 50 | 2018-02-01 | 2022-04-20 |
| Efficacy and Safety of Temodal vs Semustine in Subjects With Recurrent Glioblastoma or Anaplastic Astrocytoma (Study P03644) Temozolomide, Semustine - Glioblastoma, Astrocytoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 151 | 2005-03-02 | 2017-05-15 |
| Fluorouracil, Semustine, and Vincristine Compared With BCG in Treating Patients With Dukes' B or Dukes' C Colon Cancer That Has Been Removed By Surgery BCG vaccine, biological therapy, fluorouracil - Colorectal Cancer | Phase 3 | Completed | NSABP Foundation Inc | 1977-09-01 | 2013-06-24 |
Myelodysplastic Syndromes (3) · Hematologic Diseases (2) · Leukemia (2) · Astrocytoma (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Glioblastoma (1) · Graft vs Host Disease (1) · Leukemia, Myeloid, Acute (1) · Recurrence (1)
First Affiliated Hospital of Zhejiang University (2) · He Huang (2) · Peking University People's Hospital (2) · First Affiliated Hospital Xi'an Jiaotong University (1) · Merck Sharp & Dohme LLC (1) · NSABP Foundation Inc (1) · The First Affiliated Hospital of Soochow University (1) · Yi Luo (1)
China (8)
Xiao-Jun Huang (2) · Norman Wolmark, MD (1) · Xiaoning Wang, M.D. (1) · Yanmin Zhao, MD (1) · Yi Luo (1) · Yi Luo, MD (1) · Yue Han, Prof. (1)
PMID 15292384, PMID 3276901, PMID 33718234, PMID 39949947, PMID 40443407