5 completed, 3 unknown, 1 terminated. 9 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 5, Unknown 3, Terminated 1 |
| Phase 2 | 5 | Completed 3, Terminated 1, Unknown 1 |
Follow Eye Abnormalities: new trials by email Literature Review of Eye Abnormalities trials Research Report on Eye Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of LSCD With DM transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD - Limbal Stem-cell Deficiency, Congenital Aniridia | Phase 1 | Completed | University of Minnesota | 19 | 2023-11-30 | 2026-01-08 |
| RAFT - Clinical Trial of RAFT for Aniridia Related Keratopathy RAFT-OS - Aniridia | Phase 1 / Phase 2 | Completed | University College, London | 9 | 2021-07-28 | 2025-04-30 |
| Single Ascending Dose Study in Participants With LCA10 EDIT-101 - Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies | Phase 1 / Phase 2 | Unknown | Editas Medicine, Inc. | 34 | 2019-09-26 | 2022-12-05 |
| Extension Study to Study PQ-110-001 (NCT03140969) QR-110 - Leber Congenital Amaurosis 10, Blindness | Phase 1 / Phase 2 | Terminated | Laboratoires Thea | 9 | 2019-05-13 | 2024-10-15 |
| Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene QR-421a, Sham-procedure (dose cohort 1&2 only) - Retinitis Pigmentosa, Usher Syndrome Type 2 | Phase 1 / Phase 2 | Completed | ProQR Therapeutics | 20 | 2019-03-06 | 2022-04-20 |
| Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis triamcinolone acetonide (Triesence®) - Uveitis, Intermediate Uveitis | Phase 1 / Phase 2 | Completed | Clearside Biomedical, Inc. | 11 | 2013-02-01 | 2021-02-21 |
| Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients Travoprost ophthalmic solution, 0.004% (new formulation) - Glaucoma, Ocular Hypertension | Phase 1 | Completed | Alcon Research | 25 | 2013-01-01 | 2016-04-01 |
| Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma Deep Sclerectomy, Combined Trab - Congenital Glaucoma | Phase 1 | Unknown | King Saud University | 40 | 2011-11-01 | 2011-10-26 |
| Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma Ologen Collagen Matrix, Combined trabeculotomy-trabeculectomy - Congenital Glaucoma | Phase 1 | Unknown | National Centre of Ophthalmology named after academician Zarifa Aliyeva | 40 | 2010-09-01 | 2015-07-21 |
Eye Diseases, Hereditary (3) · Hydrophthalmos (3) · Retinal Diseases (3) · Vision Disorders (3) · Aniridia (2) · Eye Diseases (2) · Leber Congenital Amaurosis (2) · Leber Congenital Amaurosis 10 (2) · Meckel Syndrome, Type 4 (2) · Blindness (1) · Choroidal Effusions (1) · Congenital Abnormalities (1) · Genetic Diseases, Inborn (1) · Giant Cell Arteritis (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Congenital Abnormalities (7) · Eye Diseases (7) · Genetic Diseases, Inborn (4) · Nervous System Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Glaucoma, Open-Angle (3) · Infant, Newborn, Diseases (3) · Signs and Symptoms (3) · Uveal Diseases (3) · Eye Diseases, Hereditary (2) · Glaucoma (2) · Iris Diseases (2) · Neurologic Manifestations (2)
Adrenal Cortex Hormones (1) · Intravitreal Injections (1) · Triamcinolone (1) · Triamcinolone Acetonide (1)
Alcon Research (1) · Clearside Biomedical, Inc. (1) · Editas Medicine, Inc. (1) · King Saud University (1) · Laboratoires Thea (1) · National Centre of Ophthalmology named after academician Zarifa Aliyeva (1) · ProQR Therapeutics (1) · University College, London (1) · University of Minnesota (1)
United States (5) · Azerbaijan (1) · Belgium (1) · Canada (1) · France (1) · Saudi Arabia (1) · United Kingdom (1)
Julie Daniels (1) · Nigar Makhmudova (1) · Sajjad Ahmad (1) · Saleh A. Al-Obeidan, MD (1) · Stephen Kaufman, MD (1) · Subha Venkataraman (1) · Thomas Ciulla, MD (1)
PMID 27980877, PMID 31215818, PMID 33497524, PMID 34629400, PMID 37418643, PMID 38709228, PMID 42490097
2018 (2)