9 completed, 4 unknown, 3 terminated, 1 enrolling by invitation. 5 Not applicable, 5 Phase 2, 3 Phase 1, 3 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 4, Enrolling by invitation 1 |
| Phase 2 | 5 | Unknown 3, Completed 1, Terminated 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 3 | 3 | Terminated 2, Completed 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Emesis: new trials by email Literature Review of Emesis trials Research Report on Emesis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Antiemetic Effects of Increased Splanchnic Perfusion, Induced by the Gut Hormone GIP, in Healthy Individuals Glucose-dependent Insulinotropic Polypeptide (GIP), GLP-1 (7-36) amide, Apomorphine Injectable Solution - Emesis | Not applicable | Enrolling by invitation | University of Copenhagen | 14 | 2026-05-19 | 2026-07-07 |
| The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy Cannabidiol - Lean Body Mass, Cannabis | Phase 1 | Completed | University of Copenhagen | 32 | 2020-12-01 | 2023-07-24 |
| Evaluation of Meclizine Orodispersible Tablet Pharmacokinetic in Human Volunteers Meclizine Hydrochloride - Emesis | Phase 1 / Phase 2 | Unknown | Mansoura University | 6 | 2020-06-01 | 2020-09-25 |
| MinSafeStart - Decision Aid Tool for Better Treatment of Nausea and Vomiting During Pregnancy MinSafeStart app - Hyperemesis Gravidarum, Emesis | Not applicable | Completed | Hedvig Marie Egeland Nordeng | 217 | 2019-09-02 | 2023-11-28 |
| Trial to Evaluate Efficacy of Olanzapine With Short-acting 5HT3 Inhibitors in Chemotherapy-induced Nausea & Vomiting (CINV) Prophylaxis Olanzapine, Aprepitant Pill, Ondansetron - Emesis, Vomiting | Phase 2 | Unknown | Blokhin's Russian Cancer Research Center | 130 | 2018-05-25 | 2018-07-05 |
| Promoting Safe Medication Use in Pregnancy in the Era of Real-World Data - The SafeStart Study Pharmacist consultation - Pregnancy Early, Emesis | Not applicable | Completed | Hedvig Marie Egeland Nordeng | 369 | 2018-02-06 | 2023-11-28 |
| DAnish Nausea Study In Advanced Cancer-Epidemiology: A Danish Multicenter Trial to Investigate the Prevalence and Treatment of Nausea and/or Vomiting in Patients With Advanced Cancer. Advanced Cancer, Nausea | Completed | Signe Harder | 821 | 2016-02-01 | 2018-08-23 | |
| Post- Surgery Recovery: Nerve Blocks w/ Sedation vs. Nerve Block w/ Either Sedation/Gen. Anesthesia Nausea, Emesis | Completed | Hospital for Special Surgery, New York | 55 | 2015-12-01 | 2019-10-02 | |
| Study Assessing Fosaprepitant in Advanced NSCLC Patients Treated With Carboplatin Based Chemotherapy FOSAPREPITANT (Emend), Placebo - Non-small Cell Lung Cancer, Vomiting | Phase 2 | Unknown | Ajeet Gajra | 150 | 2015-04-01 | 2015-04-03 |
| Prevention of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients. Dexamethasone, Ondansetron, Aprepitant, Arm A: Standard Anti-emetic regimen - Emesis | Phase 4 | Unknown | Ottawa Hospital Research Institute | 323 | 2011-09-01 | 2017-01-30 |
| High Protein Intake to Decrease Emesis and Promote Patient Satisfaction in Labor Protein Shake - Emesis | Not applicable | Completed | University of Pittsburgh | 150 | 2010-08-01 | 2013-02-04 |
| Different Feeding Methods After Pyloromyotomy ad lib feedings after pyloromyotomy, FLAP diet after pyloromyotomy - Emesis | Not applicable | Completed | Children's Mercy Hospital Kansas City | 150 | 2010-07-01 | 2013-05-29 |
| Comparison of Olanzapine and Metoclopramide For Treatment Of bReakThrough Emesis olanzapine, metoclopramide - Emesis | Phase 2 | Terminated | Karin Jordan | 23 | 2010-07-01 | 2016-05-11 |
| Pharmacokinetic Evaluation of Subcutaneous Versus Intravenous Palonosetron in Cancer Treated With Chemotherapy Palonosetron - Emesis | Phase 1 / Phase 2 | Completed | Clinica Universidad de Navarra, Universidad de Navarra | 29 | 2009-10-01 | 2015-01-27 |
| Aprepitant in the Prevention of Cisplatin-induced Delayed Emesis aprepitant + dexamethasone, metoclopramide + dexamethasone - Emesis | Phase 3 | Terminated | S. Maria Hospital, Terni | 303 | 2009-09-01 | 2014-01-06 |
| Aprepitant in the Prevention of Delayed Emesis Induced by Cyclophosphamide Plus Anthracyclines in Breast Cancer Patients Aprepitant, dexamethasone - Emesis | Phase 3 | Terminated | S. Maria Hospital, Terni | 580 | 2009-09-01 | 2013-01-23 |
| Dexamethasone Study: Impact on Quality of Life of Continuing Dexamethasone Following Emetogenic Chemotherapy Dexamethasone - Cancer, Emesis | Phase 3 | Completed | University Health Network, Toronto | 86 | 2005-01-01 | 2012-06-28 |
Vomiting (17) · Nausea (9) · Neoplasms (2) · Appetitive Behavior (1) · Breast Neoplasms (1) · Cachexia (1) · Carcinoma, Non-Small-Cell Lung (1) · Dysgeusia (1) · Hyperemesis Gravidarum (1) · Marijuana Abuse (1) · Medication Adherence (1) · Pyloric Stenosis (1)
Pathological Conditions, Signs and Symptoms (17) · Signs and Symptoms (17) · Signs and Symptoms, Digestive (17) · Behavior (2) · Neoplasms (2) · Neoplasms by Site (2) · Behavior, Animal (1) · Body Weight (1) · Body Weight Changes (1) · Breast Diseases (1) · Bronchial Neoplasms (1) · Carcinoma, Bronchogenic (1) · Chemically-Induced Disorders (1) · Digestive System Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1)
Aprepitant (5) · Dexamethasone (5) · Metoclopramide (2) · Olanzapine (2) · Ondansetron (2) · Calcium Dobesilate (1) · Cannabidiol (1) · Incretins (1) · Meclizine (1) · Palonosetron (1) · Sodium Chloride (1) · fosaprepitant (1) · glucagon-like peptide 1 (7-36)amide (1)
Hedvig Marie Egeland Nordeng (2) · S. Maria Hospital, Terni (2) · University of Copenhagen (2) · Ajeet Gajra (1) · Blokhin's Russian Cancer Research Center (1) · Children's Mercy Hospital Kansas City (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Hospital for Special Surgery, New York (1) · Karin Jordan (1) · Mansoura University (1) · Ottawa Hospital Research Institute (1) · Signe Harder (1) · University Health Network, Toronto (1) · University of Pittsburgh (1)
United States (4) · Denmark (3) · Canada (2) · Italy (2) · Norway (2) · Egypt (1) · Germany (1) · Russia (1) · Spain (1)
Fausto Roila, MD (2) · Ajeet Gajra, MD FACP (1) · Alaa Y. Darwesh, Dr (1) · Belen Sadaba, MD, PhD (1) · Hedvig Nordeng (1) · Henrik Schultz (1) · Henrik Schultz, MSc (1) · Ian Tannock, MD PhD (1) · Jacques Ya Deau, MD, PhD (1) · Jens Rikardt Andersen, MD (1) · Karin Jordan, MD (1) · Manuel C Vallejo, MD (1) · Mark Clemons, Dr. (1) · Sebastian W Nielsen, MD (1) · Shawn D St. Peter, MD (1)
PMID 16314401, PMID 10824073, PMID 11497388, PMID 12712486, PMID 12784346, PMID 14504060, PMID 14559886, PMID 14635083, PMID 14966097, PMID 15837996, PMID 16408862, PMID 16766588, PMID 23551108, PMID 23936162, PMID 24323030, PMID 24587006, PMID 25743855, PMID 25834396, PMID 26562292, PMID 33298010, PMID 35787487, PMID 37156960, PMID 8996133
2008 (3)