1 active not recruiting, 1 completed, 1 recruiting. 3 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Active not recruiting 1, Completed 1, Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Diffuse Astrocytoma: new trials by email Literature Review of Diffuse Astrocytoma trials Research Report on Diffuse Astrocytoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas Biospecimen Collection, Eflornithine, Lumbar Puncture - Anaplastic Oligodendroglioma, Astrocytoma, IDH-Mutant, Grade 3 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 33 | 2026-06-23 | 2026-06-24 |
| Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma Biospecimen Collection, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma | Phase 2 | Active not recruiting | NRG Oncology | 120 | 2018-01-23 | 2026-07-28 |
| Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors Dabrafenib, trametinib, Carboplatin - Diffuse Astrocytoma, Anaplastic Astrocytoma | Phase 2 | Completed | Novartis Pharmaceuticals | 151 | 2017-12-28 | 2023-12-13 |
Astrocytoma (3) · Glioma (3) · Oligodendroglioma (3) · Glioblastoma (2) · Ganglioglioma (1) · Ganglioneuroma (1) · Lymphoma, Follicular (1) · Neurocytoma (1)
Neoplasms (3) · Neoplasms by Histologic Type (3) · Neoplasms, Germ Cell and Embryonal (3) · Neoplasms, Glandular and Epithelial (3) · Neoplasms, Nerve Tissue (3) · Neoplasms, Neuroepithelial (3) · Neuroectodermal Tumors (3) · Brain Diseases (1) · Brain Neoplasms (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Hemic and Lymphatic Diseases (1) · Immune System Diseases (1) · Immunoproliferative Disorders (1) · Lymphatic Diseases (1)
Magnetic Resonance Spectroscopy (2) · Specimen Handling (2) · Carboplatin (1) · Eflornithine (1) · Proton Therapy (1) · Protons (1) · Radiotherapy, Intensity-Modulated (1) · Spinal Puncture (1) · Temozolomide (1) · Transurethral Resection of Bladder (1) · Vincristine (1) · dabrafenib (1) · trametinib (1)
Mayo Clinic (1) · NRG Oncology (1) · Novartis Pharmaceuticals (1)
United States (3) · Argentina (1) · Australia (1) · Belgium (1) · Brazil (1) · Canada (1) · Czechia (1) · Denmark (1) · Finland (1) · France (1) · Germany (1) · Israel (1) · Italy (1) · Japan (1) · Netherlands (1)
David R Grosshans (1) · Terence C. Burns, MD, PhD (1)
PMID 34331515, PMID 37610803, PMID 37643378, PMID 37733309, PMID 41740060
2015 (1), U10CA180868 (1)