4 completed, 2 unknown, 1 recruiting, 1 terminated. 8 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 4, Unknown 2, Recruiting 1, Terminated 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Chronic Thromboembolic Pulmonary Hypertension: new trials by email Literature Review of Chronic Thromboembolic Pulmonary Hypertension trials Research Report on Chronic Thromboembolic Pulmonary Hypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Balloon Pulmonary Angioplasty vs. Combined Approach With Pulmonary Artery Denervation in CTEPH: Effectiveness Comparison Balloon Pulmonary Angioplasty combined with Pulmonary Artery Denervation, Balloon Pulmonary Angioplasty with Sham Pulmonary Artery Denervation - Chronic Thromboembolic Pulmonary Hypertension | Phase 2 / Phase 3 | Unknown | Boris Dzudovic | 20 | 2024-04-01 | 2024-04-02 |
| 129Xe MRI Cardiopulmonary Hyperpolarized Xe129, Oxygen Administration - Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Recruiting | Bastiaan Driehuys | 125 | 2024-01-12 | 2026-02-04 |
| Dapagliflozin in Pulmonary Arterial Hypertension Dapagliflozin 10 MG [Farxiga], Placebo - Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Completed | Mads Ersbøll | 52 | 2023-01-01 | 2026-01-21 |
| Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Riociguat, Placebo, Pulmonary endarterectomy - Chronic Thromboembolic Pulmonary Hypertension, CTEPH | Phase 2 | Terminated | International CTEPH Association | 14 | 2018-08-17 | 2021-06-22 |
| Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy Radiofrequency pulmonary artery denervation, Ablation catheter, Swan-Ganz catheter for right heart catheterization - Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Unknown | Novosibirsk Scientific Research Institute for Circulatory Pathology | 50 | 2015-08-01 | 2016-06-03 |
| Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Macitentan - Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Completed | Actelion | 76 | 2015-02-03 | 2025-03-30 |
| Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Macitentan, Placebo - Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Completed | Actelion | 80 | 2014-08-20 | 2025-03-30 |
| Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH Cardiac PET imaging using F-18-FDG, N-13 ammonia( NH3) - Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Completed | Ottawa Heart Institute Research Corporation | 6 | 2014-05-01 | 2018-08-29 |
Anemia (1) · Dyspnea (1) · Lung Diseases, Interstitial (1) · Polycythemia (1) · Pulmonary Arterial Hypertension (1)
Lung Diseases (2) · Respiratory Tract Diseases (2) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1) · Hypertension, Pulmonary (1) · Pathological Conditions, Signs and Symptoms (1) · Respiration Disorders (1) · Signs and Symptoms (1) · Signs and Symptoms, Respiratory (1)
macitentan (2) · Catheter Ablation (1) · Oxygen (1) · dapagliflozin (1) · riociguat (1)
Actelion (2) · Bastiaan Driehuys (1) · Boris Dzudovic (1) · International CTEPH Association (1) · Mads Ersbøll (1) · Novosibirsk Scientific Research Institute for Circulatory Pathology (1) · Ottawa Heart Institute Research Corporation (1)
France (3) · Germany (3) · Russia (3) · United Kingdom (3) · Belgium (2) · China (2) · Czechia (2) · Hungary (2) · Lithuania (2) · Mexico (2) · Poland (2) · Switzerland (2) · Thailand (2) · Turkey (Türkiye) (2) · Ukraine (2)
Alexander Chernyavskiy, PhD (1) · Alexander Romanov, PhD (1) · David Jenkins, MD (1) · Erin McGuire (1) · Evgeny Pokushalov, PhD (1) · Joseph Mammarappallil, MD (1) · Kelly Papadakis, MD (1) · Lisa M Mielniczuk, MD (1) · Slobodan Obradovic, MD, PhD (1)