16 completed, 4 unknown, 3 active not recruiting, 3 recruiting. 16 Phase 2, 5 Phase 3, 4 Phase 1, 1 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Defining the Clinical Potential of Mass Response As a Biomarker for Patient Tumor Sensitivity to Drugs Stage III Breast Cancer, Stage IV Breast Cancer | Withdrawn | Travera Inc | 2024-11-01 | 2024-11-25 | ||
| Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx) Pleural Effusion, Malignant, Ascites, Malignant | Completed | Travera Inc | 72 | 2022-07-15 | 2026-04-13 | |
| Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors Spartalizumab, Tislelizumab - MSI-H Colorectal Cancer, Melanoma | Phase 2 | Active not recruiting | SOLTI Breast Cancer Research Group | 184 | 2021-04-12 | 2025-03-21 |
| Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS Dexamethasone, Placebo - Analgesia, Surgery | Phase 3 | Completed | Copenhagen University Hospital, Rigshospitalet | 18 | 2020-08-18 | 2023-03-16 |
| Cancer Genetic Testing in Ethnic Populations Biospecimen Collection, Genetic Testing - Breast Carcinoma, Carcinoma of Unknown Primary | Not applicable | Recruiting | Mayo Clinic | 1800 | 2020-01-13 | 2026-04-02 |
| Pembrolizumab in Patients With Poor-Prognosis Carcinoma of Unknown Primary Site (CUP) Pembrolizumab Injection - Carcinoma of Unknown Primary | Phase 2 | Completed | AHS Cancer Control Alberta | 33 | 2018-08-24 | 2026-07-02 |
| Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer Biospecimen Collection, Questionnaire Administration - Carcinoma of Unknown Primary, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Recruiting | M.D. Anderson Cancer Center | 471 | 2016-12-29 | 2026-10-06 | |
| Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic Laboratory Biomarker Analysis, Pembrolizumab, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Carcinoma of Unknown Primary | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 157 | 2016-08-15 | 2026-07-17 |
| Phase 2 Study of Gemcitabine and Docetaxel Combination Chemotherapy in Patients With Carcinoma of Unknown Primary gemcitabine/docetaxel combination - Carcinoma of Unknown Primary | Phase 2 | Unknown | Samsung Medical Center | 29 | 2015-10-01 | 2015-10-28 |
| Genomic Investigation of Unusual Responders Cancer, Breast Cancer | Recruiting | University Health Network, Toronto | 100 | 2013-11-01 | 2025-01-31 | |
| Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction Carboplatin, Laboratory Biomarker Analysis, Paclitaxel - Breast Carcinoma, Carcinoma of Unknown Primary | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 94 | 2011-06-20 | 2026-09-04 |
| Elective Mucosal Irradiation in Head-and-Neck Cancer of Unknown Primary Elective mucosal irradiaton - Head-and-neck Cancer, Carcinoma of Unknown Primary | Phase 2 | Unknown | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 48 | 2010-01-01 | 2019-04-09 |
| Belinostat, Carboplatin and Paclitaxel (BelCaP) Compared to Carboplatin and Paclitaxel in Patients With Cancer of Unknown Primary belinostat, carboplatin, paclitaxel, carboplatin, paclitaxel - Carcinoma of Unknown Primary | Phase 2 | Completed | Valerio Therapeutics | 89 | 2009-02-01 | 2015-07-28 |
| Gemcitabine in Treating Patients With Metastatic Cancer of Unknown Primary gemcitabine hydrochloride, quality-of-life assessment - Carcinoma of Unknown Primary, Pain | Phase 2 | Completed | Eastern Cooperative Oncology Group | 52 | 2006-06-01 | 2020-11-02 |
| PET Scans and CT Scans in Patients With Locally Advanced Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy Carcinoma of Unknown Primary, Head and Neck Cancer | Completed | Wake Forest University Health Sciences | 19 | 2006-02-01 | 2017-05-30 | |
| Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors topotecan hydrochloride - Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 19 | 2005-08-01 | 2011-06-30 |
| Gemcitabine, Docetaxel, and Capecitabine in Treating Patients With Cancer of Unknown Primary Origin capecitabine, docetaxel, gemcitabine hydrochloride - Carcinoma of Unknown Primary | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2004-07-01 | 2015-05-27 | |
| Gemcitabine and Irinotecan in Treating Patients With Cancer of Unknown Primary gemcitabine hydrochloride, irinotecan hydrochloride - Carcinoma of Unknown Primary | Phase 2 | Completed | Alliance for Clinical Trials in Oncology | 31 | 2004-02-01 | 2017-04-04 |
| Radiation Therapy in Treating Patients With Metastases to the Lymph Nodes in the Neck From an Unknown Primary Tumor radiation therapy - Carcinoma of Unknown Primary | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 600 | 2002-07-01 | 2018-07-09 |
| Combination of Carboplatin, Gemcitabine, and Capecitabine in Patients With Carcinoma of Unknown Primary Site Carboplatin, Gemcitabine, Capecitabine - Carcinoma of Unknown Primary | Phase 2 | Terminated | University of Michigan Rogel Cancer Center | 2001-05-01 | 2008-01-10 |
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Neoplasms, Unknown Primary (30) · Head and Neck Neoplasms (9) · Squamous Cell Carcinoma of Head and Neck (7) · Breast Neoplasms (6) · Lung Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (5) · Melanoma (5) · Ovarian Neoplasms (5) · Carcinoma, Renal Cell (4) · Esophageal Neoplasms (4) · Oropharyngeal Neoplasms (4) · Small Cell Lung Carcinoma (4) · Urinary Bladder Neoplasms (4) · Anus Neoplasms (3) · Carcinoma (3)
Neoplastic Processes (30) · Pathologic Processes (30) · Pathological Conditions, Signs and Symptoms (30) · Neoplasms (29) · Neoplasm Metastasis (28) · Neoplasms by Site (19) · Neoplasms by Histologic Type (15) · Neoplasms, Glandular and Epithelial (14) · Carcinoma (10) · Neoplasms, Germ Cell and Embryonal (10) · Neoplasms, Nerve Tissue (10) · Neuroectodermal Tumors (10) · Respiratory Tract Diseases (9) · Respiratory Tract Neoplasms (9) · Female Urogenital Diseases (8)
Carboplatin (6) · Gemcitabine (6) · Paclitaxel (5) · Fluorouracil (4) · Radiotherapy (4) · Filgrastim (3) · Irinotecan (3) · Amifostine (2) · Capecitabine (2) · Cisplatin (2) · Cyclophosphamide (2) · Docetaxel (2) · Etoposide (2) · Leucovorin (2) · Peripheral Blood Stem Cell Transplantation (2)
M.D. Anderson Cancer Center (2) · Memorial Sloan Kettering Cancer Center (2) · Travera Inc (2) · AHS Cancer Control Alberta (1) · Academisch Ziekenhuis Maastricht (1) · Alliance for Clinical Trials in Oncology (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dana-Farber Cancer Institute (1) · Dartmouth-Hitchcock Medical Center (1) · Eastern Cooperative Oncology Group (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fox Chase Cancer Center (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1) · Pediatric Brain Tumor Consortium (1)
United States (21) · Canada (3) · Denmark (3) · Netherlands (2) · Belgium (1) · China (1) · France (1) · Germany (1) · South Korea (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Andre A. Abitbol, MD (1) · Aung Naing (1) · Cai Grau, MD (1) · David Cescon, MD (1) · David G. Pfister, MD (1) · Eileen H Shinn (1) · Elizabeth A. Poplin, MD (1) · Esat M. Ozsahin, MD, PhD (1) · Hussein A Tawbi (1) · James J. Fischer, MD, PhD (1) · Jewel Samadder, M.D. (1) · Jose Monzon, MD (1) · Juan W. Valle, MD (1) · Kathryn M. Greven, MD (1) · Konstantin H. Dragnev, MD (1)
PMID 20407240, PMID 22815703, PMID 31533818, PMID 31953927, PMID 32188704, PMID 32303619, PMID 32534809, PMID 32912664, PMID 33415580, PMID 33427689, PMID 33491277, PMID 33770291, PMID 34241781, PMID 34725215, PMID 35618285, PMID 35999229, PMID 36200668, PMID 37568622, PMID 38416544, PMID 40212844, PMID 41143139, PMID 41935492, PMID 42342409
N01CM00100 (1), P30CA006516 (1), P30CA021765 (1), P30CA023108 (1), P30CA047904 (1), P30CA072720 (1), R21DE019954 (1), U01CA062490 (1), U01CA062502 (1), U01CA062505 (1), U01CA069856 (1), U01CA070095 (1), U01CA081457 (1), U01CA099168 (1), UM1CA186690 (1)