646 completed. 646 Phase 1, 221 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 646 | Completed 646 |
| Phase 2 | 221 | Completed 221 |
Follow Bone Marrow Diseases: new trials by email Literature Review of Bone Marrow Diseases trials Research Report on Bone Marrow Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TGRX-678 Pharmacokinetic Mass Balance [14C]TGRX-678 - Chronic Myeloid Leukemia | Phase 1 | Completed | Shenzhen TargetRx Co., Ltd. | 6 | 2025-07-07 | 2025-09-04 |
| A Clinical Study to Evaluate the Effect of Food on the Pharmacokinetic Profiles of HRS-5965 Capsules in Healthy Subjects HRS-5965 Capsules - IgA Nephropathy, Paroxysmal Nocturnal Hemoglobinuria | Phase 1 | Completed | Chengdu Suncadia Medicine Co., Ltd. | 16 | 2025-06-30 | 2025-08-20 |
| TGRX-678 Phase I Oral Pharmacokinetic Study TGRX-678 - Chronic Myeloid Leukemia | Phase 1 | Completed | Shenzhen TargetRx Co., Ltd. | 76 | 2024-11-24 | 2025-05-16 |
| To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Renal Impairment Subjects TQ05105 - Myelofibrosis | Phase 1 | Completed | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 32 | 2024-10-12 | 2025-08-24 |
| Study on Mass Balance of [14C]HSK39297 in Healthy Chinese Adult Male Subjects Carbon-14 labeled HSK39297 - Paroxysmal Nocturnal Hemoglobinuria (PNH) | Phase 1 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 7 | 2024-09-09 | 2025-02-28 |
| TP-3654 Food Effect Study TP-3654 - Myelofibroses | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 24 | 2024-03-04 | 2026-03-25 |
| Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics Treosulfan, Fludarabine - Acute Myeloid Leukaemia (AML), Myelodysplastic Syndrome (MDS) | Phase 1 | Completed | medac GmbH | 20 | 2024-02-01 | 2026-05-20 |
| Comparative Study on Pharmacokinetics of Two Formulations of Jaktinib in Healthy Adults Under Fasting Conditions Jaktinib Hydrochloride Tablets - Myelofibrosis | Phase 1 | Completed | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 52 | 2023-11-29 | 2024-01-11 |
| A Study of Single and Multiple Doses of LP-005 in Healthy Adult Participants LP-005 Dose 1 (Single), LP-005 Dose 2 (Single), LP-005 Dose 3 (Single) - Paroxysmal Nocturnal Hemoglobinuria (PNH) | Phase 1 | Completed | Longbio Pharma | 68 | 2023-11-23 | 2025-12-15 |
| Dose Escalation of BCX10013 in Participants with Paroxysmal Nocturnal Hemoglobinuria (PNH) BCX10013 - Paroxysmal Nocturnal Hemoglobinuria | Phase 1 | Completed | BioCryst Pharmaceuticals | 8 | 2023-10-24 | 2025-01-08 |
| A Study to Evaluate Drug-Drug Interaction of TQ05105 Tablets TQ05105 tablets, Itraconazole capsule, Rifampicin Capsule - Myelofibrosis | Phase 1 | Completed | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 40 | 2023-09-21 | 2025-12-12 |
| A Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic Malignancies PRT2527, Zanubrutinib, Venetoclax - Aggressive B-Cell Non-Hodgkin's Lymphoma (NHL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) | Phase 1 | Completed | Prelude Therapeutics Incorporated | 86 | 2023-09-12 | 2026-01-26 |
| Study of the Selective GlyT1 Inhibitor Bitopertin for Steroid-Refractory Diamond-Blackfan Anemia Bitopertin - Steroid-refractory Diamond-Blackfan Anemia (DBA) | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 15 | 2023-07-25 | 2026-06-30 |
| Efficacy of Daratumumab to Overcome Platelet Transfusion Refractoriness in Patients with Aplastic Anemia Daratumumab - Aplastic Anemia, Platelet Transfusion Refractoriness | Phase 1 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 10 | 2023-04-17 | 2025-01-03 |
| Navitoclax in Relapsed or Refractory High-Risk Myelodysplastic Syndrome Navitoclax, Venetoclax, Decitabine - Myelodysplastic Syndrome, Recurrent Myelodysplastic Syndrome | Phase 1 | Completed | Thomas Jefferson University | 6 | 2023-01-12 | 2026-05-19 |
| A Study of Multiple Ascending Doses MY008211A in Healthy Adults MY008211A tablets, MY008211A tablets matched placebo - Paroxysmal Nocturnal Hemoglobinuria | Phase 1 | Completed | Wuhan Createrna Science and Technology Co., Ltd | 40 | 2023-01-10 | 2023-09-08 |
| Study of the Safety and Efficacy of OMS906 in Patients With Paroxysmal Nocturnal Hemoglobinuria OMS906 - Paroxysmal Nocturnal Hemoglobinuria | Phase 1 | Completed | Omeros Corporation | 15 | 2022-12-09 | 2026-05-11 |
| Effect of Food on Pharmacokinetics of MY008211A Tablets in Healthy Adult Subjects MY008211A tablets - Paroxysmal Nocturnal Hemoglobinuria | Phase 1 | Completed | Wuhan Createrna Science and Technology Co., Ltd | 12 | 2022-09-26 | 2023-04-25 |
| A Study of Single and Multiple Dose Administration of LP-001 in Healthy Subjects LP-001 Dose 1 (Single), LP-001 Dose 2 (Single), LP-001 Dose 3 (Single) - Myelodysplastic Syndrome (MDS) | Phase 1 | Completed | Longbio Pharma | 68 | 2022-09-03 | 2025-12-15 |
| A Study to Investigate 14C-bemcentinib in Healthy Male Subjects Bemcentinib - Non-Small Cell Lung Cancer, Metastatic Melanoma | Phase 1 | Completed | BerGenBio ASA | 6 | 2022-08-02 | 2025-01-29 |
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Myelodysplastic Syndromes (334) · Leukemia, Myeloid, Acute (333) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (207) · Leukemia (201) · Leukemia, Myelomonocytic, Chronic (135) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (133) · Blast Crisis (112) · Leukemia, Lymphocytic, Chronic, B-Cell (103) · Myeloproliferative Disorders (98) · Multiple Myeloma (96) · Lymphoma, Non-Hodgkin (95) · Primary Myelofibrosis (94) · Hodgkin Disease (88) · Congenital Abnormalities (83) · Leukemia, Myeloid, Chronic-Phase (74)
Hemic and Lymphatic Diseases (646) · Hematologic Diseases (634) · Neoplasms (496) · Neoplasms by Histologic Type (493) · Leukemia, Myeloid (451) · Pathologic Processes (343) · Pathological Conditions, Signs and Symptoms (343) · Disease Attributes (337) · Chronic Disease (326) · Leukemia (285) · Immune System Diseases (265) · Immunoproliferative Disorders (256) · Lymphoproliferative Disorders (253) · Lymphatic Diseases (252)
Azacitidine (54) · Cytarabine (54) · fludarabine phosphate (52) · Cyclophosphamide (45) · Filgrastim (37) · fludarabine (34) · Peripheral Blood Stem Cell Transplantation (33) · Decitabine (31) · Imatinib Mesylate (27) · Mycophenolic Acid (27) · Tacrolimus (25) · Busulfan (24) · Cyclosporine (24) · Whole-Body Irradiation (24) · Antilymphocyte Serum (23)
National Cancer Institute (NCI) (59) · M.D. Anderson Cancer Center (43) · Fred Hutchinson Cancer Center (25) · Novartis Pharmaceuticals (21) · Memorial Sloan Kettering Cancer Center (18) · National Heart, Lung, and Blood Institute (NHLBI) (16) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (12) · Washington University School of Medicine (11) · Groupe Francophone des Myelodysplasies (9) · Masonic Cancer Center, University of Minnesota (9) · Bristol-Myers Squibb (7) · Case Comprehensive Cancer Center (7) · Celgene (7) · H. Lee Moffitt Cancer Center and Research Institute (7) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (6)
United States (507) · Germany (46) · France (45) · Canada (42) · United Kingdom (35) · Italy (30) · Australia (26) · China (25) · Japan (22) · South Korea (20) · Spain (19) · Netherlands (14) · Singapore (9) · Belgium (8) · Denmark (7)
Jorge Cortes, MD (9) · Brenda Sandmaier (6) · Ayalew Tefferi, MD (5) · Guillermo Garcia-Manero, MD (5) · John Mascarenhas, MD (4) · Jorge Cortes (4) · Judith E. Karp, MD (4) · Katsuhisa Goto (4)
PMID 27400247, PMID 32499241, PMID 16775234, PMID 34699069, PMID 11331327, PMID 11585760, PMID 12114413, PMID 12171484, PMID 12750167, PMID 15231574, PMID 15514371, PMID 15570084, PMID 15958631, PMID 16275934, PMID 16278404, PMID 16670265, PMID 16775235, PMID 16882711, PMID 16990776, PMID 17562873, PMID 17640728, PMID 17715389, PMID 17875804, PMID 17959855, PMID 17971589, PMID 18048643, PMID 18299450, PMID 18327587, PMID 18467731, PMID 18571721, PMID 18974373, PMID 19075272, PMID 19092853, PMID 19109557, PMID 19179301, PMID 19398716, PMID 19439093, PMID 19546476, PMID 19557623, PMID 19652201, PMID 19786617, PMID 19933907, PMID 20071660, PMID 20400682, PMID 20511167, PMID 20733120, PMID 20843246, PMID 20858843, PMID 20860038, PMID 20952518
P30CA006973 (13), P30CA015704 (12), U01CA070095 (11), P30CA016672 (9), U01CA062461 (9), 2016 (6), 2018 (6), P30CA033572 (5), U01CA097452 (5), 2014 (4), P01CA015396 (4), P01CA018029 (4), P30CA006516 (4), P30CA043703 (4), U01CA062491 (4)