17 completed. 17 Phase 3, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Completed 17 |
| Phase 2 | 10 | Completed 10 |
Follow Anemia, Aplastic: new trials by email Literature Review of Anemia, Aplastic trials Research Report on Anemia, Aplastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess Efficacy and Safety of PF-06462700 in Japanese Participants With Aplastic Anemia PF-06462700 - Aplastic Anemia | Phase 3 | Completed | Pfizer | 3 | 2020-07-25 | 2022-04-27 |
| Study of AMG531 (Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 24 | 2019-12-03 | 2022-05-26 |
| Study of AMG531(Romiplostim) in Patients With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 17 | 2019-04-25 | 2022-05-26 |
| Hetrombopag or Placebo in Treatment-Naive Severe Aplastic Anemia Hetrombopag Olamine+Standard Therapy, Placebo+Standard Therapy - Severe Aplastic Anemia | Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 240 | 2019-03-05 | 2024-11-07 |
| Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia Romiplostim - Aplastic Anemia | Phase 2 / Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 46 | 2016-05-01 | 2024-07-16 |
| hATG+CsA vs hATG+CsA+Eltrombopag for SAA hATG, CsA, Eltrombopag - Severe Aplastic Anemia | Phase 3 | Completed | European Society for Blood and Marrow Transplantation | 202 | 2015-07-01 | 2026-04-24 |
| Efficacy and Safety of Eltrombopag + CSA in Patients With Moderate Aplastic Anemia (EMAA) Eltrombopag, Placebo (for Eltrombopag) - Anemia, Aplastic | Phase 2 / Phase 3 | Completed | B. Höchsmann | 93 | 2015-01-27 | 2025-06-10 |
| Stem Cell Transplant (SCT) for Dyskeratosis Congenita or SAA Campath 1H, Cyclophosphamide, Fludarabine - Dyskeratosis Congenita, Aplastic Anemia | Phase 2 / Phase 3 | Completed | Masonic Cancer Center, University of Minnesota | 36 | 2007-08-01 | 2017-12-05 |
| TBI Dose De-escalation for Fanconi Anemia Cyclophosphamide, Fludarabine, Total Body Irradiation - Fanconi Anemia | Phase 2 / Phase 3 | Completed | Masonic Cancer Center, University of Minnesota | 83 | 2006-05-18 | 2021-11-24 |
| Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload Deferasirox - Thalassemia, Sickle Cell Disease | Phase 3 | Completed | Novartis Pharmaceuticals | 1683 | 2005-10-01 | 2011-06-07 |
| A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-dependent Iron Overload Deferasirox - Transfusion-dependent Iron Overload | Phase 3 | Completed | Novartis Pharmaceuticals | 1784 | 2005-04-01 | 2020-02-11 |
| Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases Fludarabine, Cyclophosphamide, Busulfan - Bone Marrow Failure, Osteopetrosis | Phase 2 / Phase 3 | Completed | Columbia University | 38 | 2002-09-01 | 2024-10-31 |
| Stem Cell Transplant for Hemoglobinopathy Busulfan, Fludarabine, ATG, TLI, Busulfan, Cyclophosphamide, ATG, GCSF, Campath, Fludarabine, Cyclophosphamide - Sickle Cell Disease, Thalassemia | Phase 2 / Phase 3 | Completed | Masonic Cancer Center, University of Minnesota | 22 | 2002-06-01 | 2020-02-27 |
| Stem Cell Transplant for Bone Marrow Failure Syndromes Stem cell transplant, Fludarabine monophosphate, Total lymphoid irradiation - Diamond-Blackfan Anemia, Kostmann's Neutropenia | Phase 2 / Phase 3 | Completed | Masonic Cancer Center, University of Minnesota | 10 | 2000-06-01 | 2017-12-28 |
| Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer anti-thymocyte globulin, busulfan, carboplatin - Chronic Myeloproliferative Disorders, Leukemia | Phase 2 / Phase 3 | Completed | Roswell Park Cancer Institute | 361 | 1998-10-19 | 2021-08-13 |
| Phase III Randomized Study of Cyclophosphamide With or Without Antithymocyte Globulin Before Bone Marrow Transplantation in Patients With Aplastic Anemia Anti-thymocyte globulin, Cyclophosphamide, Bone marrow transplantation - Aplastic Anemia | Phase 3 | Completed | Roswell Park Cancer Institute | 224 | 1998-09-01 | 2018-03-12 |
| Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders antilymphocyte serum, nandrolone - Anemia, Aplastic, Hematologic Diseases | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1982-03-01 | 2013-11-26 |
Anemia, Diamond-Blackfan (4) · Thalassemia (3) · Anemia (2) · Anemia, Sickle Cell (2) · Bone Marrow Failure Disorders (2) · Fanconi Anemia (2) · Hematologic Diseases (2) · Myelodysplastic Syndromes (2) · Primary Myelofibrosis (2) · Shwachman-Diamond Syndrome (2) · Anemia, Refractory (1) · Anemia, Refractory, with Excess of Blasts (1) · Blast Crisis (1) · Burkitt Lymphoma (1)
Bone Marrow Diseases (17) · Hemic and Lymphatic Diseases (17) · Anemia (15) · Bone Marrow Failure Disorders (15) · Hematologic Diseases (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Congenital Bone Marrow Failure Syndromes (7) · Genetic Diseases, Inborn (7) · Anemia, Hypoplastic, Congenital (6) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Red-Cell Aplasia, Pure (4) · Anemia, Hemolytic (3) · Anemia, Hemolytic, Congenital (3)
Antilymphocyte Serum (8) · Cyclophosphamide (6) · fludarabine phosphate (6) · Bone Marrow Transplantation (4) · Busulfan (4) · Whole-Body Irradiation (4) · fludarabine (4) · Alemtuzumab (3) · Stem Cell Transplantation (3) · romiplostim (3) · Deferasirox (2) · Radiotherapy (2) · eltrombopag (2) · thymoglobulin (2) · Carboplatin (1)
Masonic Cancer Center, University of Minnesota (4) · Kyowa Kirin Co., Ltd. (3) · Novartis Pharmaceuticals (2) · Roswell Park Cancer Institute (2) · B. Höchsmann (1) · Columbia University (1) · European Society for Blood and Marrow Transplantation (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Pfizer (1)
United States (8) · Japan (4) · Germany (3) · Italy (3) · Netherlands (3) · Spain (3) · United Kingdom (3) · Belgium (2) · China (2) · France (2) · Greece (2) · South Korea (2) · Switzerland (2) · Taiwan (2) · Thailand (2)
Angela Smith, MD (1) · Antonio Risitano, MD, PhD (1) · Jakub Tolar, M.D., Ph.D. (1) · James Garvin, MD, PhD (1) · Margaret L MacMillan, M.D. (1) · Neal Young (1) · Paul Orchard, MD (1) · Philip L. McCarthy, MD (1) · Regis Peffault de Latour, MD, PhD (1)
PMID 19951979, PMID 19996412, PMID 20383216, PMID 20566896, PMID 21071497, PMID 23585526, PMID 25691036, PMID 34986284, PMID 36441357, PMID 38088156, PMID 40593138, PMID 42047558, PMID 42611779
2004 (1), 2014 (1)