Anatomic Stage IV Breast Cancer AJCC v8: Clinical Trials

44 recruiting, 25 active not recruiting, 24 completed, 20 withdrawn. 61 Phase 2, 50 Phase 1, 15 Not applicable, 7 Early Phase 1, 7 Phase 3.

By phase and status

Phase	Trials	Status
Phase 2	61	Recruiting 23, Active not recruiting 11, Terminated 10, Completed 9, Withdrawn 7, Not yet recruiting 1
Phase 1	50	Recruiting 12, Active not recruiting 10, Completed 9, Withdrawn 9, Terminated 7, Suspended 2, Not yet recruiting 1
Not applicable	15	Completed 4, Recruiting 4, Withdrawn 3, Active not recruiting 2, Not yet recruiting 1, Terminated 1
Early Phase 1	7	Withdrawn 3, Completed 2, Recruiting 1, Terminated 1
Phase 3	7	Active not recruiting 2, Completed 2, Recruiting 2, Terminated 1
Phase 4	1	Recruiting 1

Follow this condition Literature Review of Anatomic Stage IV Breast Cancer AJCC v8 trials Research Report on Anatomic Stage IV Breast Cancer AJCC v8

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma	Phase 3	Recruiting	SWOG Cancer Research Network	562	2027-03-09	2026-10-13
Biology Guided Therapy Recommendations for Treatment Determination of Hormone Receptor-Positive Advanced, Unresectable or Metastatic Breast Cancer, ENDORSE Trial Biopsy Procedure, Biospecimen Collection, Bone Scan - Advanced Hormone Receptor-Positive Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8	Phase 1	Not yet recruiting	City of Hope Medical Center	20	2026-12-19	2026-05-15
Minoxidil With or Without Low-Level Red-Light Therapy for Improving Chemotherapy-Induced Alopecia in Breast Cancer Patients Electronic Health Record Review, Minoxidil, Revian RED LED-light cap - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8	Phase 2	Not yet recruiting	Ohio State University Comprehensive Cancer Center	50	2026-11-15	2026-09-02
Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer Biopsy Procedure, Biospecimen Collection, Echocardiography Test - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8	Phase 1	Recruiting	National Cancer Institute (NCI)	36	2026-10-06	2026-10-16
Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma	Phase 1	Withdrawn	National Cancer Institute (NCI)		2026-10-01	2026-08-28
A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer Best Practice, Interview, Supportive Care - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8	Not applicable	Recruiting	City of Hope Medical Center	126	2026-09-09	2026-10-16
Transcranial Direct Current Stimulation to Improve Gait for Breast Cancer Survivor's Who Received Taxene and/or Platinum Chemotherapy Sham Intervention, Survey Administration, Transcranial Direct Current Stimulation - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8	Not applicable	Not yet recruiting	University of Michigan Rogel Cancer Center	60	2026-09-01	2026-10-08
Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer Behavioral Intervention, Educational Intervention, Internet-Based Intervention - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8	Not applicable	Withdrawn	City of Hope Medical Center		2026-07-16	2026-02-04
177Lu-DOTATATE for the Treatment of Stage IV or Recurrent Breast Cancer Biopsy, Biospecimen Collection, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma	Phase 2	Recruiting	OHSU Knight Cancer Institute	10	2026-06-30	2026-06-05
A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine, Chemotherapy, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma	Phase 2	Recruiting	University of Washington	20	2026-03-24	2026-08-04
Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast Cancer Biopsy, Biospecimen Collection, Computed Tomography - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8	Phase 2	Recruiting	Roswell Park Cancer Institute	30	2026-03-03	2026-04-24
[18F]FTT Positron Emission Tomography for the Measurement of PARP Tumor Expression in Patients With Metastatic Breast Cancer Best Practice, Biopsy of Breast, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma	Phase 1 / Phase 2	Recruiting	University of Washington	22	2026-02-26	2026-05-19
Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer Biopsy, Biospecimen Collection, Cemiplimab - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma	Phase 2	Recruiting	City of Hope Medical Center	11	2026-01-30	2026-05-20
Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial Biospecimen Collection, Electronic Health Record Review, Goserelin - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8	Phase 2	Recruiting	University of Michigan Rogel Cancer Center	75	2026-01-22	2026-06-23
Living Well With Advanced Breast Cancer Non-Interventional Study - Advanced Breast Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8		Recruiting	Ohio State University Comprehensive Cancer Center	50	2026-01-13	2026-03-19
Personalized Vaccine Immunotherapy in Combination With Checkpoint Inhibitor for Treatment of Triple Negative Breast Cancer Ipilimumab, Pembrolizumab, Vaccine Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8	Phase 1	Recruiting	Emory University	18	2025-12-02	2026-01-26
A Vaccine (STEMVAC) With Standard Endocrine-Based Therapy or Chemotherapy for the Treatment of Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine, Capecitabine, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma	Phase 2	Recruiting	University of Washington	40	2025-11-17	2026-04-06
High Dose Radiation Therapy With Pembrolizumab and Chemotherapy for the Treatment of Patients With PD-L1 Positive Metastatic Triple Negative Breast Cancer Radiation Therapy, Pembrolizumab, Nab-paclitaxel - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma	Phase 2	Recruiting	Emory University	29	2025-10-22	2026-04-17
Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer Biospecimen Collection, Bone Scan, Capecitabine - Anatomic Stage IV Breast Cancer AJCC v8, Estrogen-receptor-positive Breast Cancer	Phase 2	Recruiting	Mayo Clinic	35	2025-10-01	2026-08-12
An Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Positive Breast Cancer, The UTMOST2 Trial Diagnostic Mammography, Resection, Ultrasound Imaging - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8	Phase 1	Recruiting	Mayo Clinic	20	2025-08-29	2026-09-23

Showing 20 of 135. Sign in to see all of them.

Narrower conditions

Breast Neoplasms (67)  ·  Triple Negative Breast Neoplasms (39)  ·  Lung Neoplasms (21)  ·  Neoplasm Metastasis (20)  ·  Ovarian Neoplasms (16)  ·  Carcinoma, Non-Small-Cell Lung (13)  ·  Brain Neoplasms (11)  ·  Prostatic Neoplasms (11)  ·  Melanoma (10)  ·  Pancreatic Neoplasms (8)  ·  Carcinoma, Renal Cell (6)  ·  Colorectal Neoplasms (6)  ·  Endometrial Neoplasms (6)  ·  Fallopian Tube Neoplasms (6)  ·  Carcinoma, Hepatocellular (4)

Broader conditions

Neoplasms (110)  ·  Neoplasms by Site (109)  ·  Skin Diseases (103)  ·  Skin and Connective Tissue Diseases (103)  ·  Breast Diseases (101)  ·  Breast Neoplasms (34)  ·  Urogenital Diseases (25)  ·  Urogenital Neoplasms (24)  ·  Neoplasms by Histologic Type (23)  ·  Genital Diseases (22)  ·  Female Urogenital Diseases (21)  ·  Female Urogenital Diseases and Pregnancy Complications (21)  ·  Lung Diseases (21)  ·  Neoplastic Processes (21)  ·  Pathologic Processes (21)

Interventions

Magnetic Resonance Spectroscopy (50)  ·  Specimen Handling (50)  ·  Biopsy (39)  ·  Taxes (16)  ·  pembrolizumab (16)  ·  Fulvestrant (12)  ·  X-Rays (12)  ·  Paclitaxel (11)  ·  Carboplatin (10)  ·  Letrozole (9)  ·  abemaciclib (9)  ·  olaparib (9)  ·  Albumin-Bound Paclitaxel (8)  ·  Immunoglobulin G (8)  ·  130-nm albumin-bound paclitaxel (7)

Sponsors

National Cancer Institute (NCI) (28)  ·  M.D. Anderson Cancer Center (15)  ·  Mayo Clinic (15)  ·  City of Hope Medical Center (13)  ·  Ohio State University Comprehensive Cancer Center (7)  ·  Emory University (6)  ·  OHSU Knight Cancer Institute (6)  ·  Roswell Park Cancer Institute (6)  ·  University of Washington (6)  ·  NRG Oncology (4)  ·  Thomas Jefferson University (4)  ·  SWOG Cancer Research Network (3)  ·  Fred Hutchinson Cancer Center (2)  ·  University of California, San Francisco (2)  ·  University of Michigan Rogel Cancer Center (2)

Countries

United States (124)  ·  Puerto Rico (6)  ·  Canada (5)  ·  Hong Kong (2)  ·  Ireland (2)  ·  Guam (1)  ·  Saudi Arabia (1)  ·  South Africa (1)  ·  South Korea (1)

Top investigators

Senthilkumar Damodaran (3)  ·  Anne Reb (2)  ·  Banu Arun (2)  ·  Brittany L Dulmage, MD (2)  ·  Joanne Mortimer (2)  ·  Mariya Rozenblit (2)  ·  Meghan Karuturi (2)  ·  Roisin M Connolly (2)  ·  Roy Strowd, MD (2)  ·  A P Chen (1)  ·  Agnieszka K Witkiewicz (1)  ·  Alison M Schram (1)  ·  Amy J Chien, MD (1)  ·  Ana C Garrido-Castro (1)  ·  Andrew J Brenner (1)

Results publications

PMID 32379297, PMID 12001988, PMID 17704903, PMID 19906081, PMID 19917863, PMID 20061178, PMID 20233873, PMID 20336386, PMID 20374484, PMID 20490982, PMID 20737573, PMID 21153378, PMID 21909917, PMID 21926464, PMID 22162570, PMID 23456602, PMID 24956510, PMID 25013744, PMID 26883450, PMID 2801858, PMID 33084020, PMID 33654117, PMID 34357781, PMID 35602670, PMID 35728046, PMID 36008574, PMID 36092362, PMID 36269154, PMID 36351402, PMID 36658425, PMID 37023705, PMID 37124504, PMID 37704753, PMID 38028143, PMID 3808620, PMID 38106014, PMID 38976035, PMID 39038917, PMID 39863139, PMID 39865083, PMID 40506447, PMID 40933893, PMID 40939237, PMID 41271741, PMID 41576303, PMID 42847673, PMID 42868120

NIH funding

P30CA033572 (13), P30CA138292 (5), U10CA180868 (5), UM1CA186709 (5), UM1CA186688 (4), UM1CA186689 (4), UM1CA186704 (4), P30CA016672 (3), U10CA180820 (3), UM1CA186691 (3), P30CA012197 (2), R21CA293326 (2), U10CA180821 (2), U10CA180888 (2), UM1CA186644 (2)