Advanced Solid Tumors Harboring the KRAS G12C Mutation: Clinical Trials

1 trial for Advanced Solid Tumors Harboring the KRAS G12C Mutation, newest first

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1 active not recruiting. 1 Phase 1, 1 Phase 2.

By phase and status

PhaseTrialsStatus
Phase 11Active not recruiting 1
Phase 21Active not recruiting 1

Follow Advanced Solid Tumors Harboring the KRAS G12C Mutation: new trials by email Literature Review of Advanced Solid Tumors Harboring the KRAS G12C Mutation trials Research Report on Advanced Solid Tumors Harboring the KRAS G12C Mutation

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

TrialPhaseStatusSponsorEnrollmentStartUpdated
Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments
Opnurasib, TNO155, trametinib - Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer, Advanced Solid Tumors Harboring the KRAS G12C Mutation
Phase 1 / Phase 2Active not recruitingNovartis Pharmaceuticals252026-06-082026-10-23

Narrower conditions

Carcinoma, Non-Small-Cell Lung (1)  ·  Colorectal Neoplasms (1)

Broader conditions

Bronchial Neoplasms (1)  ·  Carcinoma, Bronchogenic (1)  ·  Colonic Diseases (1)  ·  Digestive System Diseases (1)  ·  Digestive System Neoplasms (1)  ·  Gastrointestinal Diseases (1)  ·  Gastrointestinal Neoplasms (1)  ·  Intestinal Diseases (1)  ·  Intestinal Neoplasms (1)  ·  Lung Diseases (1)  ·  Lung Neoplasms (1)  ·  Neoplasms (1)  ·  Neoplasms by Site (1)  ·  Rectal Diseases (1)  ·  Respiratory Tract Diseases (1)

Interventions

Cetuximab (1)  ·  JDQ443 (1)  ·  tislelizumab (1)  ·  trametinib (1)

Sponsors

Novartis Pharmaceuticals (1)

Countries

Belgium (1)  ·  Canada (1)  ·  China (1)  ·  Denmark (1)  ·  France (1)  ·  Italy (1)  ·  Japan (1)  ·  Malaysia (1)  ·  South Korea (1)  ·  Spain (1)

NIH funding

2025 (1)