11 recruiting, 8 active not recruiting, 4 terminated, 2 withdrawn. 13 Phase 2, 10 Phase 1, 3 Not applicable, 2 Phase 3, 1 Early Phase 1.
Follow Advanced Lung Non-Small Cell Carcinoma: new trials by email Literature Review of Advanced Lung Non-Small Cell Carcinoma trials Research Report on Advanced Lung Non-Small Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Cancer Adagrasib, Biospecimen Collection, Computed Tomography - Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 | Phase 2 | Not yet recruiting | Roswell Park Cancer Institute | 29 | 2026-10-15 | 2026-09-02 |
| SX-682 and Atezolizumab for the Treatment of Advanced or Metastatic, Recurrent Non-small Cell Lung Cancer Atezolizumab, CXCR1/2 Inhibitor SX-682, Biospecimen Collection - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | University of Washington | 32 | 2026-10-06 | 2026-10-13 |
| Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study Biospecimen Collection, Immune Checkpoint Inhibitor - Advanced Biliary Tract Carcinoma, Advanced Head and Neck Squamous Cell Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 160 | 2026-04-24 | 2026-10-13 |
| GT103 in Combination With Pembrolizumab for the Treatment of Advanced or Metastatic STK11 Mutant Non-Small Cell Lung Cancer Anti-CFH Monoclonal Antibody GT103, Biopsy Procedure, Biospecimen Collection - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 28 | 2026-04-01 | 2026-08-19 |
| Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy Atezolizumab, Biospecimen Collection, Cemiplimab - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Emory University | 20 | 2025-04-09 | 2026-02-12 |
| Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial Carboplatin, Computed Tomography, Magnetic Resonance Imaging - Advanced Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 304 | 2024-07-19 | 2026-10-22 |
| Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer Biopsy, Biospecimen Collection, Carfilzomib - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 1 | Recruiting | City of Hope Medical Center | 15 | 2024-04-24 | 2026-04-03 |
| LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Recruiting | University of Rochester | 800 | 2023-12-04 | 2026-01-09 | |
| The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors Fermented Wheat Germ Extract - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Phase 1 | Suspended | University of California, Davis | 100 | 2023-06-02 | 2026-07-01 |
| EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung Cancer EMB-01, Osimertinib - Metastatic Lung Non-Small Cell Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Unknown | Shanghai EpimAb Biotherapeutics Co., Ltd. | 115 | 2023-06-01 | 2023-06-01 |
| Understanding New Cachexia Subtypes Through Observational Epidemiological Research Biospecimen Collection, Computed Tomography, Electronic health record review - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Recruiting | Kaiser Permanente | 800 | 2023-04-05 | 2026-08-20 | |
| Tai-Chi and Aerobic Exercise to Improve Emotional Symptom Cluster in Late-stage Lung Cancer Patients Tai-Chi intervention, Aerobic exercise intervention - Advanced Lung Non-Small Cell Carcinoma | Not applicable | Recruiting | The University of Hong Kong | 318 | 2023-03-13 | 2023-05-10 |
| Remote Monitoring With Health-Coaching for Lifestyle Changes in Patients With Lung Cancer Related Fatigue Exercise Counseling, Exercise Intervention, Internet-Based Intervention - Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 | Not applicable | Terminated | Mayo Clinic | 7 | 2022-08-17 | 2025-02-07 |
| Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors Antineoplastic Immune Cell, Atezolizumab, Biospecimen Collection - Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 1 | Active not recruiting | University of California, Irvine | 6 | 2022-07-20 | 2026-10-06 |
| Supportive Care Intervention (ROAR-LCT) for Patients With Stage IIIA, IIIB, and IV Lung Cancer, ROAR-LCT Trial Best Practice, Exercise Intervention, Physical Therapy - Advanced Lung Non-Small Cell Carcinoma, Advanced Lung Small Cell Carcinoma | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 100 | 2022-04-14 | 2025-11-21 |
| Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) Cobalamin, Dexamethasone, Docetaxel - Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma | Phase 2 / Phase 3 | Active not recruiting | SWOG Cancer Research Network | 82 | 2022-03-15 | 2026-05-18 |
| Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer Biopsy, Osimertinib, Triptolide Analog - Advanced Lung Non-Small Cell Carcinoma, Locally Advanced Lung Non-Small Cell Carcinoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 8 | 2022-03-07 | 2026-03-05 |
| ctDNA Analysis to Monitor the Risk of Progression After First-line Immunotherapy in Patients With Advanced NSCLC ctDNA detection - Advanced Lung Non-Small Cell Carcinoma | Active not recruiting | Fang Wu | 100 | 2022-01-24 | 2026-08-31 | |
| A Study of Sargramostim Plus Pembrolizumab with or Without Pemetrexed in Patients with Advance Non-small Cell Lung Cancer After Completion of Chemoimmunotherapy Granulocyte-Macrophage Colony-Stimulating Factor, Pembrolizumab, pemetrexed - Advanced Lung Non-Small Cell Carcinoma, Non-Small Cell Carcinoma of Lung, TNM Stage 4 | Phase 2 | Terminated | Tufts Medical Center | 5 | 2022-01-03 | 2025-01-01 |
| Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV Biospecimen Collection, Cabozantinib S-malate, Computed Tomography - Advanced Differentiated Thyroid Gland Carcinoma, Advanced Head and Neck Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 8 | 2021-11-22 | 2026-05-28 |
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Lung Neoplasms (24) · Carcinoma, Non-Small-Cell Lung (16) · Carcinoma, Renal Cell (4) · Colorectal Neoplasms (4) · Pancreatic Neoplasms (3) · Carcinoma, Hepatocellular (2) · Melanoma (2) · Neoplasm Metastasis (2) · Ovarian Neoplasms (2) · Triple Negative Breast Neoplasms (2) · Carcinoma, Medullary (1) · Carcinoma, Transitional Cell (1) · Colonic Diseases (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1)
Neoplasms (27) · Lung Diseases (26) · Neoplasms by Site (26) · Respiratory Tract Diseases (26) · Respiratory Tract Neoplasms (26) · Thoracic Neoplasms (26) · Bronchial Neoplasms (16) · Carcinoma, Bronchogenic (16) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Male Urogenital Diseases (5) · Neoplasms by Histologic Type (5) · Neoplasms, Glandular and Epithelial (5)
Magnetic Resonance Spectroscopy (11) · Specimen Handling (11) · pembrolizumab (7) · osimertinib (5) · Biopsy (4) · Pemetrexed (4) · atezolizumab (4) · Nivolumab (3) · Paclitaxel (3) · 130-nm albumin-bound paclitaxel (2) · Albumin-Bound Paclitaxel (2) · Carboplatin (2) · Disulfides (2) · Docetaxel (2) · Exercise Test (2)
National Cancer Institute (NCI) (5) · City of Hope Medical Center (2) · Emory University (2) · M.D. Anderson Cancer Center (2) · Mayo Clinic (2) · Roswell Park Cancer Institute (2) · University of California, Davis (2) · Fang Wu (1) · Kaiser Permanente (1) · OHSU Knight Cancer Institute (1) · Ohio State University Comprehensive Cancer Center (1) · SWOG Cancer Research Network (1) · Shanghai EpimAb Biotherapeutics Co., Ltd. (1) · Shirish Gadgeel (1) · The University of Hong Kong (1)
United States (25) · China (2) · Canada (1) · Hong Kong (1)
Carolyn J Presley, MD (1) · Chia-Chin Lin, PhD,FAAN,RN (1) · Christina Baik, MD, MPH (1) · Conor Steuer, MD (1) · David S Hong (1) · Dwight H Owen (1) · Edwin H Yau (1) · Erminia Massarelli (1) · Grace K Dy (1) · Haiying Cheng (1) · Jennifer W Carlisle (1) · John M Wrangle (1) · Joseph M Tuscano, MD (1) · Julie Sutcliffe (1) · Jyoti Malhotra, MD (Co-PI) (1)
PMID 38572955, PMID 39886125, PMID 39903538, PMID 40580957, PMID 42847673
P30CA033572 (3), P30CA093373 (2), P30CA138292 (2), U10CA180820 (2), K76AG074923 (1), OT2CA278691 (1), P50CA217691 (1), P50CA228944 (1), R01CA266457 (1), U10CA180888 (1), UG1CA189961 (1), UM1CA186712 (1), UM1CA186717 (1)