9 completed, 4 active not recruiting, 2 recruiting, 2 terminated. 17 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 9, Active not recruiting 4, Recruiting 2, Terminated 1, Withdrawn 1 |
| Phase 1 | 4 | Completed 2, Terminated 1, Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive: new trials by email Literature Review of Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive trials Research Report on Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia Decitabine, Ponatinib, Venetoclax - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Myeloid Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 20 | 2020-05-17 | 2026-06-05 |
| Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial Abemaciclib, Abiraterone, Afatinib - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Terminated | OHSU Knight Cancer Institute | 2 | 2020-04-01 | 2024-03-04 |
| Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation Letermovir, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine, Placebo Administration - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 2 | Active not recruiting | City of Hope Medical Center | 7 | 2019-11-27 | 2025-11-14 |
| Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Reducing CMV Related Complications in Patients With Blood Cancer Undergoing Donor Stem Cell Transplant Multi-antigen CMV-Modified Vaccinia Ankara Vaccine, Laboratory Biomarker Analysis, Placebo - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Withdrawn | City of Hope Medical Center | 2018-12-01 | 2018-11-21 | |
| Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia Blinatumomab, Cyclophosphamide, Cytarabine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 22 | 2018-02-08 | 2026-08-19 |
| Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer Cyclophosphamide, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission | Phase 2 | Terminated | Roswell Park Cancer Institute | 31 | 2017-12-07 | 2025-07-04 |
| Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia Blinatumomab, Cytarabine, Methotrexate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 90 | 2017-11-29 | 2026-05-20 |
| Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma Anti-Thymocyte Globulin, Busulfan, Clofarabine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 6 | 2017-10-13 | 2023-10-11 |
| Personalized NK Cell Therapy in CBT Allogeneic Natural Killer Cell Line NK-92, Anti-Thymocyte Globulin, Busulfan - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 100 | 2016-05-19 | 2026-07-30 |
| Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant Laboratory Biomarker Analysis, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine, Placebo - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Active not recruiting | City of Hope Medical Center | 102 | 2015-12-21 | 2026-07-28 |
| Vaccine Therapy in Reducing the Frequency of Cytomegalovirus Events in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant CMVpp65-A*0201 peptide vaccine, Placebo, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | City of Hope Medical Center | 61 | 2015-05-21 | 2025-03-03 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 84 | 2015-03-23 | 2026-06-01 |
| Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation, Cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 54 | 2014-04-22 | 2024-01-24 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 20 | 2014-04-10 | 2024-03-12 |
| Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies Aldesleukin, Allogeneic CD56-positive CD3-negative Natural Killer Cells, Allogeneic Hematopoietic Stem Cell Transplantation - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Erythroid Leukemia | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 63 | 2013-06-11 | 2023-11-07 |
| NK Cells in Cord Blood Transplantation Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 1 | Unknown | M.D. Anderson Cancer Center | 13 | 2013-05-03 | 2020-02-11 |
| Eltrombopag Olamine in Treating Thrombocytopenia in Patients With Chronic Myeloid Leukemia or Myelofibrosis Receiving Tyrosine Kinase Therapy Eltrombopag Olamine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Phase 2 / Phase 3 | Completed | M.D. Anderson Cancer Center | 21 | 2012-01-13 | 2023-09-26 |
| Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia Cyclophosphamide, Cytarabine, Dexamethasone - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 88 | 2011-10-05 | 2026-10-06 |
| Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer Fludarabine Phosphate, Total-Body Irradiation, Peripheral Blood Stem Cell Transplantation - Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Previously Treated Myelodysplastic Syndrome | Phase 2 | Completed | Fred Hutchinson Cancer Center | 210 | 2004-11-01 | 2019-10-30 |
Leukemia, Myeloid, Accelerated Phase (19) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (14) · Leukemia, Myeloid, Acute (12) · Blast Crisis (11) · Myelodysplastic Syndromes (11) · Lymphoma, Non-Hodgkin (10) · Hodgkin Disease (9) · Leukemia, Lymphocytic, Chronic, B-Cell (9) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (9) · Leukemia, Myeloid, Chronic-Phase (9) · Myeloproliferative Disorders (7) · Primary Myelofibrosis (7) · Leukemia, Biphenotypic, Acute (5) · Leukemia, Myelomonocytic, Chronic (5) · Anemia, Refractory, with Excess of Blasts (3)
Bone Marrow Diseases (19) · Chronic Disease (19) · Disease Attributes (19) · Hematologic Diseases (19) · Hemic and Lymphatic Diseases (19) · Leukemia (19) · Leukemia, Myeloid (19) · Neoplasms (19) · Neoplasms by Histologic Type (19) · Pathologic Processes (19) · Pathological Conditions, Signs and Symptoms (19) · Immune System Diseases (15) · Immunoproliferative Disorders (15) · Leukemia, Lymphoid (15) · Lymphatic Diseases (15)
Cyclophosphamide (8) · Whole-Body Irradiation (8) · fludarabine phosphate (7) · Peripheral Blood Stem Cell Transplantation (6) · Tacrolimus (6) · CT-P10 (5) · Methotrexate (5) · Mycophenolic Acid (5) · Rituximab (5) · merphos (5) · ponatinib (5) · Melphalan (4) · Busulfan (3) · Cord Blood Stem Cell Transplantation (3) · Cytarabine (3)
M.D. Anderson Cancer Center (10) · City of Hope Medical Center (4) · Fred Hutchinson Cancer Center (3) · OHSU Knight Cancer Institute (1) · Roswell Park Cancer Institute (1)
United States (19) · Denmark (1) · Germany (1)
Elias Jabbour (3) · Ryotaro Nakamura, MD (3) · Marie Bleakley (2) · Amanda Olson (1) · Brenda Sandmaier (1) · Chitra Hosing (1) · Gautam Borthakur (1) · Lara Davis, MD (1) · Nicholas Short (1) · Philip McCarthy, MD (1) · Richard E Champlin (1) · Ryotaro Nakamura (1) · Samer Srour (1) · Warren Fingrut, MD (1)
PMID 35007144, PMID 10204198, PMID 25085357, PMID 26432046, PMID 27760761, PMID 30501869, PMID 32040960, PMID 32499241, PMID 34312462, PMID 36402146, PMID 36600670, PMID 39028925, PMID 39303729, PMID 39863139, PMID 40369607
P01CA018029 (3), R01HL121568 (2), K23CA154532 (1), P01CA049639 (1), P30CA015704 (1), P30CA016672 (1), R01CA077544 (1), R01CA181045 (1), R01CA211044 (1)