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Most Influential JAMA Papers (2025-09 Version)

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JAMA: The Journal of the American Medical Association is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of biomedicine. Paper Digest Team analyze all papers published on JAMA in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Version: 2025-09)

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Paper Digest Team
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TABLE 1: Most Influential JAMA Papers (2025-09 Version)

Year Rank Paper Author(s)
2024 1 International Consensus Criteria for Pediatric Sepsis and Septic Shock
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Abstract: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third …		 LUREGN J SCHLAPBACH et. al.
2024 2 Thyroid Cancer: A Review
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Abstract: Approximately 43 720 new cases of thyroid carcinoma are expected to be diagnosed in 2023 in the US. Five-year relative survival is approximately 98.5%. This review summarizes …		 Laura Boucai; Mark Zafereo; Maria E Cabanillas;
2024 3 Screening for Breast Cancer: US Preventive Services Task Force Recommendation Statement
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Abstract: Among all US women, breast cancer is the second most common cancer and the second most common cause of cancer death. In 2023, an estimated 43 170 women died of breast cancer. …		 WANDA K NICHOLSON et. al.
2024 4 Perioperative Toripalimab Plus Chemotherapy for Patients With Resectable Non-Small Cell Lung Cancer: The Neotorch Randomized Clinical Trial
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Abstract: Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non-small cell lung cancer (NSCLC). However, the optimal combination of …		 SHUN LU et. al.
2024 5 Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care
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Abstract: An accurate blood test for Alzheimer disease (AD) could streamline the diagnostic workup and treatment of AD. To prospectively evaluate a clinically available AD blood test in …		 SEBASTIAN PALMQVIST et. al.
2024 6 Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults, 2011-2020
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 Rahul Aggarwal; John W Ostrominski; Muthiah Vaduganathan;
2024 7 Testing and Evaluation of Health Care Applications of Large Language Models: A Systematic Review
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Abstract: Large language models (LLMs) can assist in various health care activities, but current evaluation approaches may not adequately identify the most useful application areas. To …		 SUHANA BEDI et. al.
2024 8 Long-Term Outcomes of Medical Management Vs Bariatric Surgery in Type 2 Diabetes
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Abstract: Randomized clinical trials of bariatric surgery have been limited in size, type of surgical procedure, and follow-up duration. To determine long-term glycemic control and safety …		 ANITA P COURCOULAS et. al.
2024 9 Interstitial Lung Disease: A Review
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Abstract: Interstitial lung disease (ILD) consists of a group of pulmonary disorders characterized by inflammation and/or fibrosis of the lung parenchyma associated with progressive dyspnea …		 Toby M Maher;
2024 10 Analysis of Breast Cancer Mortality in The US-1975 to 2019
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Abstract: Breast cancer mortality in the US declined between 1975 and 2019. The association of changes in metastatic breast cancer treatment with improved breast cancer mortality is …		 JENNIFER L CASWELL-JIN et. al.
2023 1 Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
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Abstract: There are limited efficacious treatments for Alzheimer disease. To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Multicenter …		 JOHN R SIMS et. al.
2023 2 Diabetic Foot Ulcers: A Review
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Abstract: Approximately 18.6 million people worldwide are affected by a diabetic foot ulcer each year, including 1.6 million people in the United States. These ulcers precede 80% of lower …		 David G Armstrong; Tze-Woei Tan; Andrew J M Boulton; Sicco A Bus;
2023 3 Glioblastoma and Other Primary Brain Malignancies in Adults: A Review
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Abstract: Malignant primary brain tumors cause more than 15 000 deaths per year in the United States. The annual incidence of primary malignant brain tumors is approximately 7 per 100 000 …		 Lauren R Schaff; Ingo K Mellinghoff;
2023 4 Development of A Definition of Postacute Sequelae of SARS-CoV-2 Infection
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Abstract: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 …		 TANAYOTT THAWEETHAI et. al.
2023 5 Autism Spectrum Disorder: A Review
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Highlight: This review summarizes evidence on the diagnosis and treatment of ASD.		 Tomoya Hirota; Bryan H King;
2023 6 Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial
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Abstract: The effect of continued treatment with tirzepatide on maintaining initial weight reduction is unknown. To assess the effect of tirzepatide, with diet and physical activity, on the …		 LOUIS J ARONNE et. al.
2023 7 Appropriateness of Cardiovascular Disease Prevention Recommendations Obtained From A Popular Online Chat-Based Artificial Intelligence Model
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 ASHISH SARRAJU et. al.
2023 8 Ulcerative Colitis in Adults: A Review
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Abstract: Ulcerative colitis (UC) is a chronic inflammatory condition of the colon, with a prevalence exceeding 400 per 100 000 in North America. Individuals with UC have a lower life …		 Beatriz Gros; Gilaad G Kaplan;
2023 9 Obesity Management in Adults: A Review
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Abstract: Obesity affects approximately 42% of US adults and is associated with increased rates of type 2 diabetes, hypertension, cardiovascular disease, sleep disorders, osteoarthritis, …		 ARIELLE ELMALEH-SACHS et. al.
2023 10 Nonhuman Authors and Implications for The Integrity of Scientific Publication and Medical Knowledge
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 Annette Flanagin; Kirsten Bibbins-Domingo; Michael Berkwits; Stacy L Christiansen;
2022 1 Diagnosis and Management of Multiple Myeloma: A Review
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Abstract: Multiple myeloma is a hematologic malignancy characterized by presence of abnormal clonal plasma cells in the bone marrow, with potential for uncontrolled growth causing …		 ANDREW J COWAN et. al.
2022 2 Effect of Weekly Subcutaneous Semaglutide Vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial
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Abstract: Phase 3 trials have not compared semaglutide and liraglutide, glucagon-like peptide-1 analogues available for weight management. To compare the efficacy and adverse event profiles …		 DOMENICA M RUBINO et. al.
2022 3 Association Between 3 Doses of MRNA COVID-19 Vaccine and Symptomatic Infection Caused By The SARS-CoV-2 Omicron and Delta Variants
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Abstract: Assessing COVID-19 vaccine performance against the rapidly spreading SARS-CoV-2 Omicron variant is critical to inform public health guidance. To estimate the association between …		 EMMA K ACCORSI et. al.
2022 4 Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021
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Abstract: Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID). To estimate the proportion of males and females …		 SARAH WULF HANSON et. al.
2022 5 Myocarditis Cases Reported After MRNA-Based COVID-19 Vaccination in The US From December 2020 to August 2021
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Abstract: Vaccination against COVID-19 provides clear public health benefits, but vaccination also carries potential risks. The risks and outcomes of myocarditis after COVID-19 vaccination …		 MATTHEW E OSTER et. al.
2022 6 Diagnosis and Treatment of Acute Coronary Syndromes: A Review
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Abstract: Acute coronary syndromes (ACS) are characterized by a sudden reduction in blood supply to the heart and include ST-segment elevation myocardial infarction (STEMI), non-STEMI …		 Deepak L Bhatt; Renato D Lopes; Robert A Harrington;
2022 7 Statin Use for The Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement
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Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and death in the US and is the cause of more than 1 of every 4 deaths. Coronary heart disease is the single leading …		 CAROL M MANGIONE et. al.
2022 8 The Quintuple Aim for Health Care Improvement: A New Imperative to Advance Health Equity
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 Shantanu Nundy; Lisa A Cooper; Kedar S Mate;
2022 9 Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in The US, 2013-2018
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Abstract: Despite improvement during recent decades, extremely preterm infants continue to contribute disproportionately to neonatal mortality and childhood morbidity. To review survival, …		 EDWARD F BELL et. al.
2022 10 Target Trial Emulation: A Framework for Causal Inference From Observational Data
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 Miguel A Hernán; Wei Wang; David E Leaf;
2021 1 Strengthening The Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement
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Abstract: Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce …		 VERONIKA W SKRIVANKOVA et. al.
2021 2 Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review
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Abstract: Colorectal cancer (CRC) is the third most common cause of cancer mortality worldwide with more than 1.85 million cases and 850 000 deaths annually. Of new colorectal cancer …		 Leah H Biller; Deborah Schrag;
2021 3 Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review
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Abstract: Osteoarthritis (OA) is the most common joint disease, affecting an estimated more than 240 million people worldwide, including an estimated more than 32 million in the US. …		 Jeffrey N Katz; Kaetlyn R Arant; Richard F Loeser;
2021 4 Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement
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Abstract: Colorectal cancer is the third leading cause of cancer death for both men and women, with an estimated 52 980 persons in the US projected to die of colorectal cancer in 2021. …		 KARINA W DAVIDSON et. al.
2021 5 Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement
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Abstract: Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 …		 ALEX H KRIST et. al.
2021 6 Updated Guidance on The Reporting of Race and Ethnicity in Medical and Science Journals
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 Annette Flanagin; Tracy Frey; Stacy L Christiansen;
2021 7 Pancreatic Cancer: A Review
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Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer, with approximately 60 430 new diagnoses expected in 2021 in the US. The incidence of PDAC is increasing by …		 Wungki Park; Akhil Chawla; Eileen M O’Reilly;
2021 8 Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for The US Preventive Services Task Force
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Abstract: Colorectal cancer (CRC) remains a significant cause of morbidity and mortality in the US. To systematically review the effectiveness, test accuracy, and harms of screening for CRC …		 Jennifer S Lin; Leslie A Perdue; Nora B Henrikson; Sarah I Bean; Paula R Blasi;
2021 9 Antibody Response to 2-Dose SARS-CoV-2 MRNA Vaccine Series in Solid Organ Transplant Recipients
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 BRIAN J BOYARSKY et. al.
2021 10 Effect of Bamlanivimab As Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial
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Abstract: Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19. To determine the effect of bamlanivimab …		 ROBERT L GOTTLIEB et. al.
2020 1 Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China
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Abstract: In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical …		 DAWEI WANG et. al.
2020 2 Characteristics of and Important Lessons From The Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of A Report of 72 314 Cases From The Chinese Center for Disease Control and Prevention
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 Zunyou Wu; Jennifer M McGoogan;
2020 3 Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in The New York City Area
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Abstract: There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19). To describe …		 SAFIYA RICHARDSON et. al.
2020 4 Detection of SARS-CoV-2 in Different Types of Clinical Specimens
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 WENLING WANG et. al.
2020 5 Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of The Lombardy Region, Italy
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Abstract: In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information …		 GIACOMO GRASSELLI et. al.
2020 6 Presumed Asymptomatic Carrier Transmission of COVID-19
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 YAN BAI et. al.
2020 7 Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review
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Abstract: The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a worldwide sudden and substantial …		 W Joost Wiersinga; Andrew Rhodes; Allen C Cheng; Sharon J Peacock; Hallie C Prescott;
2020 8 Case-Fatality Rate And Characteristics Of Patients Dying In Relation To COVID-19 In Italy
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 Graziano Onder; Giovanni Rezza; Silvio Brusaferro;
2020 9 Persistent Symptoms in Patients After Acute COVID-19
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 Angelo Carfì; Roberto Bernabei; Francesco Landi;
2020 10 Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review
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Abstract: The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to …		 James M Sanders; Marguerite L Monogue; Tomasz Z Jodlowski; James B Cutrell;
2019 1 Breast Cancer Treatment: A Review
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Abstract: Breast cancer will be diagnosed in 12% of women in the United States over the course of their lifetimes and more than 250 000 new cases of breast cancer were diagnosed in the …		 Adrienne G Waks; Eric P Winer;
2019 2 Chronic Kidney Disease Diagnosis and Management: A Review
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Abstract: Chronic kidney disease (CKD) is the 16th leading cause of years of life lost worldwide. Appropriate screening, diagnosis, and management by primary care clinicians are necessary …		 Teresa K Chen; Daphne H Knicely; Morgan E Grams;
2019 3 Effect of Catheter Ablation Vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial
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Abstract: Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain. To determine whether …		 DOUGLAS L PACKER et. al.
2019 4 Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis
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Abstract: Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes may allow more precise therapy and improve care. To derive sepsis phenotypes from clinical data, …		 CHRISTOPHER W SEYMOUR et. al.
2019 5 Diagnosis and Management of Dementia: Review
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Abstract: Worldwide, 47 million people live with dementia and, by 2050, the number is expected to increase to 131 million. Dementia is an acquired loss of cognition in multiple cognitive …		 Zoe Arvanitakis; Raj C Shah; David A Bennett;
2019 6 Effect of Intensive Vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial
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Abstract: There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia. To evaluate the effect of intensive blood pressure control on risk of …		 JEFF D WILLIAMSON et. al.
2019 7 Systemic Therapy For Locally Advanced And Metastatic Non-Small Cell Lung Cancer: A Review
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Abstract: Non-small cell lung cancer remains the leading cause of cancer death in the United States. Until the last decade, the 5-year overall survival rate for patients with metastatic …		 Kathryn C Arbour; Gregory J Riely;
2019 8 Waste In The US Health Care System: Estimated Costs And Potential For Savings
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Abstract: The United States spends more on health care than any other country, with costs approaching 18% of the gross domestic product (GDP). Prior studies estimated that approximately 30% …		 William H Shrank; Teresa L Rogstad; Natasha Parekh;
2019 9 Ending The HIV Epidemic
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 A. Fauci; R. Redfield; G. Sigounas; Michael D. Weahkee; B. Giroir;
2019 10 In-Hospital Cardiac Arrest: A Review
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Abstract: In-hospital cardiac arrest is common and associated with a high mortality rate. Despite this, in-hospital cardiac arrest has received little attention compared with other …		 Lars W Andersen; Mathias J Holmberg; Katherine M Berg; Michael W Donnino; Asger Granfeldt;
2018 1 The Physical Activity Guidelines for Americans
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Abstract: Approximately 80% of US adults and adolescents are insufficiently active. Physical activity fosters normal growth and development and can make people feel, function, and sleep …		 KATRINA L PIERCY et. al.
2018 2 Preferred Reporting Items for A Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies: The PRISMA-DTA Statement
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Abstract: Systematic reviews of diagnostic test accuracy synthesize data from primary diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference …		 MATTHEW D F MCINNES et. al.
2018 3 Diagnosis and Management of Rheumatoid Arthritis: A Review
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Abstract: Rheumatoid arthritis (RA) occurs in about 5 per 1000 people and can lead to severe joint damage and disability. Significant progress has been made over the past 2 decades …		 Daniel Aletaha; Josef S Smolen;
2018 4 Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults By Sex and Age, 2007-2008 to 2015-2016
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 Craig M Hales; Cheryl D Fryar; Margaret D Carroll; David S Freedman; Cynthia L Ogden;
2018 5 Prevalence of Burnout Among Physicians: A Systematic Review
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Abstract: Burnout is a self-reported job-related syndrome increasingly recognized as a critical factor affecting physicians and their patients. An accurate estimate of burnout prevalence …		 LISA S ROTENSTEIN et. al.
2018 6 Big Data And Machine Learning In Health Care
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 Andrew L Beam; Isaac S Kohane;
2018 7 Health Care Spending in The United States and Other High-Income Countries
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Abstract: Health care spending in the United States is a major concern and is higher than in other high-income countries, but there is little evidence that efforts to reform US health care …		 Irene Papanicolas; Liana R Woskie; Ashish K Jha;
2018 8 The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States
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Abstract: Several studies have measured health outcomes in the United States, but none have provided a comprehensive assessment of patterns of health by state. To use the results of the …		 ALI H MOKDAD et. al.
2018 9 Screening For Prostate Cancer: US Preventive Services Task Force Recommendation Statement
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Abstract: In the United States, the lifetime risk of being diagnosed with prostate cancer is approximately 13%, and the lifetime risk of dying of prostate cancer is 2.5%. The median age of …		 DAVID C GROSSMAN et. al.
2018 10 Acute Respiratory Distress Syndrome: Advances In Diagnosis And Treatment
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Abstract: Acute respiratory distress syndrome (ARDS) is a life-threatening form of respiratory failure that affects approximately 200 000 patients each year in the United States, resulting …		 Eddy Fan; Daniel Brodie; Arthur S Slutsky;
2017 1 Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer
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Abstract: Application of deep learning algorithms to whole-slide pathology images can potentially improve diagnostic accuracy and efficiency. Assess the performance of automated deep …		 BABAK EHTESHAMI BEJNORDI et. al.
2017 2 Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers
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Abstract: The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. To estimate age-specific risks of breast, ovarian, and …		 KAROLINE B KUCHENBAECKER et. al.
2017 3 Mendelian Randomization
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 Connor A Emdin; Amit V Khera; Sekar Kathiresan;
2017 4 Effect Of Tumor-Treating Fields Plus Maintenance Temozolomide Vs Maintenance Temozolomide Alone On Survival In Patients With Glioblastoma: A Randomized Clinical Trial
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Abstract: Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity …		 ROGER STUPP et. al.
2017 5 Global Burden Of Hypertension And Systolic Blood Pressure Of At Least 110 To 115 Mm Hg, 1990-2015
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Abstract: Elevated systolic blood (SBP) pressure is a leading global health risk. Quantifying the levels of SBP is important to guide prevention policies and interventions. To estimate the …		 MOHAMMAD H FOROUZANFAR et. al.
2017 6 Trends in Thyroid Cancer Incidence and Mortality in The United States, 1974-2013
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Abstract: Thyroid cancer incidence has increased substantially in the United States over the last 4 decades, driven largely by increases in papillary thyroid cancer. It is unclear whether …		 Hyeyeun Lim; Susan S Devesa; Julie A Sosa; David Check; Cari M Kitahara;
2017 7 Development And Validation Of A Deep Learning System For Diabetic Retinopathy And Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes
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Abstract: A deep learning system (DLS) is a machine learning technology with potential for screening diabetic retinopathy and related eye diseases. To evaluate the performance of a DLS in …		 DANIEL SHU WEI TING et. al.
2017 8 Overall Survival Results of A Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment
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2017 9 What We Are
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Abstract: ChildSight, the domestic program of Helen Keller International, is a cost-effective, schoolbased program whose mission is to improve the vision and academic potential of children …		 C. Halberstadt;
2017 10 Prevalence And Ethnic Pattern Of Diabetes And Prediabetes In China In 2013
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Abstract: Previous studies have shown increasing prevalence of diabetes in China, which now has the world’s largest diabetes epidemic. To estimate the recent prevalence and to investigate …		 LIMIN WANG et. al.
2016 1 The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
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Abstract: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell …		 MERVYN SINGER et. al.
2016 2 Developing A Newdefinition and Assessing Newclinical Criteria for Septic Shock
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2016 3 Developing A New Definition and Assessing New Clinical Criteria for Septic Shock: For The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
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Abstract: Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in epidemiology challenge the …		 MANU SHANKAR-HARI et. al.
2016 4 Development And Validation Of A Deep Learning Algorithm For Detection Of Diabetic Retinopathy In Retinal Fundus Photographs
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Abstract: Deep learning is a family of computational methods that allow an algorithm to program itself by learning from a large set of examples that demonstrate the desired behavior, …		 VARUN GULSHAN et. al.
2016 5 CDC Guideline for Prescribing Opioids for Chronic Pain–United States, 2016
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Abstract: Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious risks, …		 Deborah Dowell; Tamara M Haegerich; Roger Chou;
2016 6 Epidemiology, Patterns Of Care, And Mortality For Patients With Acute Respiratory Distress Syndrome In Intensive Care Units In 50 Countries
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Abstract: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). To evaluate intensive …		 GIACOMO BELLANI et. al.
2016 7 Assessment Of Clinical Criteria For Sepsis: For The Third International Consensus Definitions For Sepsis And Septic Shock (Sepsis-3)
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Abstract: The Third International Consensus Definitions Task Force defined sepsis as life-threatening organ dysfunction due to a dysregulated host response to infection. The performance …		 CHRISTOPHER W SEYMOUR et. al.
2016 8 Trends in Obesity Among Adults in The United States, 2005 to 2014
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Abstract: Between 1980 and 2000, the prevalence of obesity increased significantly among adult men and women in the United States; further significant increases were observed through …		 Katherine M Flegal; Deanna Kruszon-Moran; Margaret D Carroll; Cheryl D Fryar; Cynthia L Ogden;
2016 9 Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses: Second Panel on Cost-Effectiveness in Health and Medicine
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Abstract: Since publication of the report by the Panel on Cost-Effectiveness in Health and Medicine in 1996, researchers have advanced the methods of cost-effectiveness analysis, and policy …		 GILLIAN D SANDERS et. al.
2016 10 Trends in Obesity Prevalence Among Children and Adolescents in The United States, 1988-1994 Through 2013-2014
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Abstract: Previous analyses of obesity trends among children and adolescents showed an increase between 1988-1994 and 1999-2000, but no change between 2003-2004 and 2011-2012, except for a …		 CYNTHIA L OGDEN et. al.
2015 1 Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012
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Abstract: Extremely preterm infants contribute disproportionately to neonatal morbidity and mortality. To review 20-year trends in maternal/neonatal care, complications, and mortality among …		 BARBARA J STOLL et. al.
2015 2 Transfusion Of Plasma, Platelets, And Red Blood Cells In A 1:1:1 Vs A 1:1:2 Ratio And Mortality In Patients With Severe Trauma: The PROPPR Randomized Clinical Trial
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Abstract: Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood …		 JOHN B HOLCOMB et. al.
2015 3 Nonalcoholic Fatty Liver Disease: A Systematic Review
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Abstract: Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis affect approximately 30% and 5%, respectively, of the US population. In patients with nonalcoholic …		 Mary E Rinella;
2015 4 Cannabinoids For Medical Use: A Systematic Review And Meta-analysis
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Abstract: Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear. To conduct a systematic review of …		 PENNY F WHITING et. al.
2015 5 Preferred Reporting Items for Systematic Review and Meta-Analyses of Individual Participant Data: The PRISMA-IPD Statement
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Abstract: Systematic reviews and meta-analyses of individual participant data (IPD) aim to collect, check, and reanalyze individual-level data from all studies addressing a particular …		 LESLEY A STEWART et. al.
2015 6 Preferred Reporting Items for A Systematic Review and Meta-analysis of Individual Participant Data: The PRISMA-IPD Statement
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Abstract: Importance Systematic reviews and meta-analyses of individual participant data (IPD) aim to collect, check, and reanalyze individual-level data from all studies addressing a …		 L. STEWART et. al.
2015 7 Comparison Of MR/ultrasound Fusion-guided Biopsy With Ultrasound-guided Biopsy For The Diagnosis Of Prostate Cancer
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Abstract: Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect prostate cancer. The implications of targeted biopsy alone vs standard extended-sextant …		 M MINHAJ SIDDIQUI et. al.
2015 8 Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
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Abstract: Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology …		 WILLEMIJN J JANSEN et. al.
2015 9 Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From The American Cancer Society
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Abstract: Breast cancer is a leading cause of premature mortality among US women. Early detection has been shown to be associated with reduced breast cancer morbidity and mortality. To …		 KEVIN C OEFFINGER et. al.
2015 10 Prevalence Of The Metabolic Syndrome In The United States, 2003-2012
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 Maria Aguilar; Taft Bhuket; Sharon Torres; Benny Liu; Robert J Wong;
2014 1 Prevalence of Childhood and Adult Obesity in The United States, 2011-2012
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Abstract: More than one-third of adults and 17% of youth in the United States are obese, although the prevalence remained stable between 2003-2004 and 2009-2010. To provide the most recent …		 Cynthia L Ogden; Margaret D Carroll; Brian K Kit; Katherine M Flegal;
2014 2 The Pathophysiology and Treatment of Glaucoma: A Review
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Abstract: Glaucoma is a worldwide leading cause of irreversible vision loss. Because it may be asymptomatic until a relatively late stage, diagnosis is frequently delayed. A general …		 Robert N Weinreb; Tin Aung; Felipe A Medeiros;
2014 3 Caregiver Burden: A Clinical Review
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Abstract: Caregiver burden may result from providing care for patients with chronic illness. It can occur in any of the 43.5 million individuals providing support to midlife and older …		 Ronald D Adelman; Lyubov L Tmanova; Diana Delgado; Sarah Dion; Mark S Lachs;
2014 4 Mortality Related To Severe Sepsis And Septic Shock Among Critically Ill Patients In Australia And New Zealand, 2000-2012
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Abstract: Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality …		 Kirsi-Maija Kaukonen; Michael Bailey; Satoshi Suzuki; David Pilcher; Rinaldo Bellomo;
2014 5 Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
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Abstract: Targeting oncogenic drivers (genomic alterations critical to cancer development and maintenance) has transformed the care of patients with lung adenocarcinomas. The Lung Cancer …		 MARK G KRIS et. al.
2014 6 Prevalence Of Obesity In The United States
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 Cynthia L Ogden; Margaret D Carroll; Katherine M Flegal;
2014 7 Smoking Prevalence And Cigarette Consumption In 187 Countries, 1980-2012
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Abstract: Tobacco is a leading global disease risk factor. Understanding national trends in prevalence and consumption is critical for prioritizing action and evaluating tobacco control …		 MARIE NG et. al.
2014 8 Management Of Sickle Cell Disease: Summary Of The 2014 Evidence-based Report By Expert Panel Members
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Abstract: Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly 100,000 individuals in the United States and is associated with many acute and chronic …		 BARBARA P YAWN et. al.
2014 9 Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents from 2001 to 2009
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Abstract: Despite concern about an epidemic, there are limited data on trends in prevalence of either type 1 or type 2 diabetes across US race and ethnic groups. To estimate changes in …		 DANA DABELEA et. al.
2014 10 Pharmacological Treatment Of Parkinson Disease: A Review
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Abstract: Parkinson disease is the second most common neurodegenerative disease worldwide. Although no available therapies alter the underlying neurodegenerative process, symptomatic …		 Barbara S Connolly; Anthony E Lang;
2013 1 2014 Evidence-based Guideline for The Management of High Blood Pressure in Adults: Report from The Panel Members Appointed to The Eighth Joint National Committee (JNC 8)
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Abstract: Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated …		 PAUL A JAMES et. al.
2013 2 Prevalence And Control Of Diabetes In Chinese Adults
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Abstract: Noncommunicable chronic diseases have become the leading causes of mortality and disease burden worldwide. To investigate the prevalence of diabetes and glycemic control in the …		 YU XU et. al.
2013 3 The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors
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Abstract: Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. To measure the burden of …		 CHRISTOPHER J L MURRAY et. al.
2013 4 Glioblastoma And Other Malignant Gliomas: A Clinical Review
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Abstract: Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population or 17,000 new diagnoses per year. …		 Antonio Omuro; Lisa M DeAngelis;
2013 5 Prevalence, Awareness, Treatment, And Control Of Hypertension In Rural And Urban Communities In High-, Middle-, And Low-income Countries
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Abstract: Hypertension is the most important preventable cause of morbidity and mortality globally, yet there are relatively few data collected using standardized methods. To examine …		 CLARA K CHOW et. al.
2013 6 Acute Skeletal Muscle Wasting in Critical Illness
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Abstract: Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment. To perform a comprehensive prospective characterization of skeletal muscle …		 ZUDIN A PUTHUCHEARY et. al.
2013 7 Adjuvant Chemotherapy With Gemcitabine And Long-term Outcomes Among Patients With Resected Pancreatic Cancer: The CONKO-001 Randomized Trial
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Abstract: The prognosis for patients with pancreatic cancer is poor, even after resection with curative intent. Gemcitabine-based chemotherapy is standard treatment for advanced pancreatic …		 HELMUT OETTLE et. al.
2013 8 The Inevitable Application Of Big Data To Health Care
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 Travis B Murdoch; Allan S Detsky;
2013 9 Menopausal Hormone Therapy and Health Outcomes During The Intervention and Extended Poststopping Phases of The Women’s Health Initiative Randomized Trials
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Abstract: Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention. To report a comprehensive, integrated …		 JOANN E MANSON et. al.
2013 10 Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients with Node-positive Breast Cancer: The ACOSOG Z1071 (Alliance) Clinical Trial
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Abstract: Sentinel lymph node (SLN) surgery provides reliable nodal staging information with less morbidity than axillary lymph node dissection (ALND) for patients with clinically …		 JUDY C BOUGHEY et. al.
2012 1 Evidence-Based Guideline for The Management of High Blood Pressure in Adults
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2012 2 Prevalence Of Obesity And Trends In The Distribution Of Body Mass Index Among US Adults, 1999-2010
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Abstract: Between 1980 and 1999, the prevalence of adult obesity (body mass index [BMI] ≥30) increased in the United States and the distribution of BMI changed. More recent data suggested a …		 Katherine M Flegal; Margaret D Carroll; Brian K Kit; Cynthia L Ogden;
2012 3 Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010
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Abstract: The prevalence of childhood obesity increased in the 1980s and 1990s but there were no significant changes in prevalence between 1999-2000 and 2007-2008 in the United States. To …		 Cynthia L Ogden; Margaret D Carroll; Brian K Kit; Katherine M Flegal;
2012 4 Association Between Sustained Virological Response And All-cause Mortality Among Patients With Chronic Hepatitis C And Advanced Hepatic Fibrosis
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Abstract: Chronic hepatitis C virus (HCV) infection outcomes include liver failure, hepatocellular carcinoma (HCC), and liver-related death. To assess the association between sustained …		 ADRIAAN J VAN DER MEER et. al.
2012 5 Eliminating Waste In US Health Care
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Abstract: The need is urgent to bring US health care costs into a sustainable range for both public and private payers. Commonly, programs to contain costs use cuts, such as reductions in …		 Donald M Berwick; Andrew D Hackbarth;
2012 6 Bariatric Surgery And Long-term Cardiovascular Events
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Abstract: Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking. To study the association between …		 LARS SJÖSTRÖM et. al.
2012 7 Harrison’s Principles of Internal Medicine
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2012 8 Benefits and Harms of CT Screening for Lung Cancer: A Systematic Review
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Abstract: Lung cancer is the leading cause of cancer death. Most patients are diagnosed with advanced disease, resulting in a very low 5-year survival. Screening may reduce the risk of …		 PETER B BACH et. al.
2012 9 Diagnostic Accuracy of Fractional Flow Reserve from Anatomic CT Angiography
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Abstract: Coronary computed tomographic (CT) angiography is a noninvasive anatomic test for diagnosis of coronary stenosis that does not determine whether a stenosis causes ischemia. In …		 JAMES K MIN et. al.
2012 10 Comparison of Allogeneic Vs Autologous Bone Marrow–derived Mesenchymal Stem Cells Delivered By Transendocardial Injection in Patients with Ischemic Cardiomyopathy: The POSEIDON Randomized Trial
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Abstract: Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, their safety …		 JOSHUA M HARE et. al.
2011 1 Gait Speed And Survival In Older Adults
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Abstract: Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, …		 STEPHANIE STUDENSKI et. al.
2011 2 Axillary Dissection Vs No Axillary Dissection In Women With Invasive Breast Cancer And Sentinel Node Metastasis: A Randomized Clinical Trial
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Abstract: Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal dissection affects survival. To …		 ARMANDO E GIULIANO et. al.
2011 3 Risk Prediction Models For Hospital Readmission: A Systematic Review
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Abstract: Predicting hospital readmission risk is of great interest to identify which patients would benefit most from care transition interventions, as well as to risk-adjust readmission …		 DEVAN KANSAGARA et. al.
2011 4 Vitamin E And The Risk Of Prostate Cancer: The Selenium And Vitamin E Cancer Prevention Trial (SELECT)
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Abstract: The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a …		 ERIC A KLEIN et. al.
2011 5 Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
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Abstract: Severe sepsis is typically characterized by initial cytokine-mediated hyperinflammation. Whether this hyperinflammatory phase is followed by immunosuppression is controversial. …		 JONATHAN S BOOMER et. al.
2011 6 Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients
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Abstract: Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, …		 ERIC A ENGELS et. al.
2011 7 Standard- Vs High-dose Clopidogrel Based On Platelet Function Testing After Percutaneous Coronary Intervention: The GRAVITAS Randomized Trial
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Abstract: High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this …		 MATTHEW J PRICE et. al.
2011 8 Effect Of Screening On Ovarian Cancer Mortality: The Prostate, Lung, Colorectal And Ovarian (PLCO) Cancer Screening Randomized Controlled Trial
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Abstract: Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality. To evaluate the effect of screening for ovarian …		 SAUNDRA S BUYS et. al.
2011 9 Risk Of Incident Diabetes With Intensive-dose Compared With Moderate-dose Statin Therapy: A Meta-analysis
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Abstract: A recent meta-analysis demonstrated that statin therapy is associated with excess risk of developing diabetes mellitus. To investigate whether intensive-dose statin therapy is …		 DAVID PREISS et. al.
2011 10 Technology-enhanced Simulation For Health Professions Education: A Systematic Review And Meta-analysis
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Abstract: Although technology-enhanced simulation has widespread appeal, its effectiveness remains uncertain. A comprehensive synthesis of evidence may inform the use of simulation in …		 DAVID A COOK et. al.
2010 1 Prevalence And Trends In Obesity Among US Adults, 1999-2008
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Abstract: The prevalence of obesity increased in the United States between 1976-1980 and 1988-1994 and again between 1988-1994 and 1999-2000. To examine trends in obesity from 1999 through …		 Katherine M Flegal; Margaret D Carroll; Cynthia L Ogden; Lester R Curtin;
2010 2 Prevalence Of High Body Mass Index In US Children And Adolescents, 2007-2008
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Abstract: The prevalence of high body mass index (BMI) among children and adolescents in the United States appeared to plateau between 1999 and 2006. To provide the most recent estimates of …		 Cynthia L Ogden; Margaret D Carroll; Lester R Curtin; Molly M Lamb; Katherine M Flegal;
2010 3 Stereotactic Body Radiation Therapy For Inoperable Early Stage Lung Cancer
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Abstract: Patients with early stage but medically inoperable lung cancer have a poor rate of primary tumor control (30%-40%) and a high rate of mortality (3-year survival, 20%-35%) with …		 ROBERT TIMMERMAN et. al.
2010 4 Long-term Cognitive Impairment And Functional Disability Among Survivors Of Severe Sepsis
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Abstract: Cognitive impairment and functional disability are major determinants of caregiving needs and societal health care costs. Although the incidence of severe sepsis is high and …		 Theodore J Iwashyna; E Wesley Ely; Dylan M Smith; Kenneth M Langa;
2010 5 US Trends In Prevalence, Awareness, Treatment, And Control Of Hypertension, 1988-2008
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Abstract: Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure …		 Brent M Egan; Yumin Zhao; R Neal Axon;
2010 6 Delirium In Elderly Patients And The Risk Of Postdischarge Mortality, Institutionalization, And Dementia: A Meta-analysis
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Abstract: Delirium is a common and serious complication in elderly patients. Evidence suggests that delirium is associated with long-term poor outcome but delirium often occurs in …		 JOOST WITLOX et. al.
2010 7 Antidepressant Drug Effects And Depression Severity: A Patient-level Meta-analysis
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Abstract: Antidepressant medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect …		 JAY C FOURNIER et. al.
2010 8 Trends, Major Medical Complications, And Charges Associated With Surgery For Lumbar Spinal Stenosis In Older Adults
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Abstract: In recent decades, the fastest growth in lumbar surgery occurred in older patients with spinal stenosis. Trials indicate that for selected patients, decompressive surgery offers …		 RICHARD A DEYO et. al.
2010 9 Higher Vs Lower Positive End-expiratory Pressure In Patients With Acute Lung Injury And Acute Respiratory Distress Syndrome: Systematic Review And Meta-analysis
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Abstract: Trials comparing higher vs lower levels of positive end-expiratory pressure (PEEP) in adults with acute lung injury or acute respiratory distress syndrome (ARDS) have been …		 MATTHIAS BRIEL et. al.
2010 10 Annual High-dose Oral Vitamin D And Falls And Fractures In Older Women: A Randomized Controlled Trial
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Abstract: Improving vitamin D status may be an important modifiable risk factor to reduce falls and fractures; however, adherence to daily supplementation is typically poor. To determine …		 KERRIE M SANDERS et. al.