8 completed, 3 recruiting, 2 active not recruiting, 1 enrolling by invitation. 2 Phase 2, 1 Early Phase 1, 1 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency 20-valent pneumococcal conjugate vaccine - Alpha 1-Antitrypsin, COPD | Phase 4 | Recruiting | University of Alabama at Birmingham | 30 | 2025-09-03 | 2025-11-10 |
| PiMZ Longitudinal Cohort (PiMZ Logic) Alpha 1-Antitrypsin Deficiency, Emphysema or COPD | Recruiting | Columbia University | 80 | 2025-05-30 | 2026-01-16 | |
| Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease Alpha 1-Antitrypsin Deficiency, Genetic Disease | Active not recruiting | Columbia University | 286 | 2022-03-23 | 2026-01-16 | |
| Alpha-1 Research Registry Alpha 1-Antitrypsin Deficiency | Recruiting | Alpha-1 Foundation | 5000 | 2019-06-20 | 2026-08-19 | |
| COPD Exacerbation Blood and Urine Biomarkers Study Chronic Obstructive Pulmonary Disease, Acute Exacerbation Copd | Terminated | Columbia University | 7 | 2018-06-07 | 2024-06-04 | |
| Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency Aspirin, Placebo, Withdrawal from alpha1 antitrypsin replacement therapy - Alpha-1 Antitrypsin Deficiency, Emphysema | Phase 2 | Completed | Columbia University | 15 | 2017-01-01 | 2021-02-17 |
| Alpha-1 Antitrypsin Deficiency Adult Liver Study Liver Biopsy (Biopsy Group Only) - Alpha-1 Antitrypsin Deficiency | Active not recruiting | St. Louis University | 120 | 2013-12-01 | 2026-04-27 | |
| Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients exercise training - Chronic Obstructive Pulmonary Disease, Alpha-1-antitrypsin-deficiency | Not applicable | Completed | Schön Klinik Berchtesgadener Land | 20 | 2010-02-01 | 2013-12-17 |
| Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD) Alpha-1 Antitrypsin Deficiency, Chronic Obstructive Pulmonary Disease | Completed | Alpha-1 Foundation | 3457 | 2008-01-01 | 2012-01-19 | |
| The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency | Completed | Medical University of South Carolina | 49 | 2007-08-01 | 2018-01-23 | |
| Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency rAAV1-CB-hAAT - Alpha 1-Antitrypsin Deficiency | Phase 1 | Completed | University of Massachusetts, Worcester | 9 | 2006-02-01 | 2016-12-15 |
| Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency rAAV2-CB-hAAT Gene Vector - Alpha 1-Antitrypsin Deficiency | Early Phase 1 | Completed | University of Massachusetts, Worcester | 12 | 2004-03-01 | 2020-04-10 |
| Alpha-1 Foundation DNA and Tissue Bank Alpha 1 Antitrypsin Deficiency | Enrolling by invitation | University of Florida | 5000 | 2002-12-01 | 2026-01-15 | |
| 4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency? 4-PBA - Alpha 1-Antitrypsin Deficiency | Phase 2 | Completed | University of Florida | 12 | 2001-11-01 | 2014-01-03 |
| Alpha-1 Foundation Research Registry Alpha 1-Antitrypsin Deficiency | Completed | Medical University of South Carolina | 6655 | 2000-04-01 | 2021-03-03 |
alpha 1-Antitrypsin Deficiency (15) · Pulmonary Disease, Chronic Obstructive (7) · Emphysema (2) · Cough (1) · Fibrosis (1) · Genetic Diseases, Inborn (1) · Liver Diseases (1) · Lung Diseases (1)
4-phenylbutylamine (1) · Aspirin (1) · Endurance Training (1) · Exercise (1) · Resistance Training (1)
United States (14) · Germany (1) · Puerto Rico (1)
Charlie Strange, MD (2) · Mark L Brantly, MD (2) · Monica Goldklang, MD (2) · Terence R. Flotte, MD (2) · Andrew A Wilson, MD (1) · Carrie Aaron, MD (1) · Charlie Strange, M.D. (1) · David A. Brenner, MD (1) · Jeanine D'Armiento, MD, PhD (1) · Jeanine M D'Armiento, MD, PhD (1) · Jeffrey Teckman, MD (1) · Karina Serban, MD (1) · Klaus Kenn, Dr. med. (1) · Robert A Sandhaus, M.D., Ph.D. (1)
PMID 10988213, PMID 15822045, PMID 16403617, PMID 20054436, PMID 21424325, PMID 22835581, PMID 34256305, PMID 39263815
R01HL069877 (2), 1UG3HL152323 (1), U54RR019498 (1)