39 completed, 3 terminated. 24 Phase 2, 18 Phase 1, 2 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 24 | Completed 22, Terminated 2 |
| Phase 1 | 18 | Completed 18 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
| Not applicable | 1 | Completed 1 |
Follow perifosine: new trials by email Literature Review of perifosine trials Research Report on perifosine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas Cytoreductive surgery, Perifosine, Temsirolimus - Brain Tumor, Recurrent, Glioblastoma | Phase 1 | Completed | Andrew B Lassman, MD | 10 | 2014-12-08 | 2023-05-25 |
| A Food Effect and QTc Study of Perifosine in Patients With Advanced Malignancies perifosine - Cancer | Phase 1 | Completed | AEterna Zentaris | 24 | 2012-01-24 | 2018-03-14 |
| Perifosine Plus Capecitabine Versus Placebo Plus Capecitabine in Patients With Refractory Advanced Colorectal Cancer Capecitabine, Perifosine, Placebo - Colorectal Cancer | Phase 3 | Completed | AEterna Zentaris | 468 | 2010-04-01 | 2013-07-02 |
| Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma Laboratory Biomarker Analysis, Perifosine, Temsirolimus - Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 36 | 2010-01-27 | 2021-07-19 |
| Perifosine With Temsirolimus for Recurrent Pediatric Solid Tumors perifosine + temsirolimus - Pediatric Solid Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 23 | 2010-01-01 | 2017-03-10 |
| Assessment of Efficacy and Safety of Perifosine, Bortezomib and Dexamethasone in Multiple Myeloma Patients Perifosine, Perifosine Placebo, Bortezomib - Multiple Myeloma | Phase 3 | Terminated | AEterna Zentaris | 135 | 2009-12-01 | 2018-02-09 |
| Study of Perifosine + Capecitabine for Colon Cancer Patients Perifosine, Capecitabine - Colon Cancer | Phase 1 | Completed | AEterna Zentaris | 10 | 2009-10-01 | 2018-06-28 |
| Perifosine in Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma perifosine - Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | Phase 2 | Completed | Daphne Friedman | 16 | 2009-08-01 | 2013-05-27 |
| Study of Single Agent Perifosine for Recurrent Pediatric Solid Tumors perifosine - Solid Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 38 | 2008-10-01 | 2017-08-01 |
| Open Label Trial of Perifosine in Patients Currently Being Treated on Perifosine Trials in Solid Tumors or Multiple Myeloma Perifosine, Trastuzumab, Tamoxifen - Non Small Cell Lung Cancer, Solid Tumors | Not applicable | Completed | AEterna Zentaris | 10 | 2008-05-01 | 2018-03-15 |
| Ph II Study of Perifosine for Patients With Carcinoma of the Kidney Perifosine - Kidney Cancer | Phase 2 | Completed | AEterna Zentaris | 50 | 2007-07-01 | 2018-02-05 |
| A Phase II Trial of Perifosine Following Tyrosine Kinase Inhibitor (TKI) - Failure in Patients With Renal Cancer Perifosine - Renal Cell Carcinoma | Phase 2 | Completed | AEterna Zentaris | 24 | 2007-03-01 | 2018-03-01 |
| Perifosine and Docetaxel in Patients With Relapsed Epithelial Ovarian Cancer Perifosine, Docetaxel - Ovarian Cancer | Phase 1 | Completed | M.D. Anderson Cancer Center | 22 | 2007-02-01 | 2016-02-19 |
| Phase I Study of Perifosine + Lenalidomide and Dexamethasone for Patients With Multiple Myeloma Perifosine, Lenalidomide, Dexamethasone - Multiple Myeloma | Phase 1 | Completed | AEterna Zentaris | 32 | 2006-12-01 | 2012-07-06 |
| A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Perifosine, Loperamide, Allopurinol - Chondrosarcomas, Alveolar Soft Part Sarcomas | Phase 2 | Completed | AEterna Zentaris | 72 | 2006-11-01 | 2018-03-07 |
| Perifosine + Sunitinib Malate for Patients With Advanced Cancers Perifosine, Sunitinib Malate - Renal Cancer, GIST | Phase 1 | Completed | AEterna Zentaris | 15 | 2006-10-01 | 2014-02-19 |
| A Phase II Study of Perifosine in Patients With Relapsed/Refractory Waldenström's Macroglobulinemia Perifosine - Waldenström's Macroglobulinemia | Phase 2 | Completed | AEterna Zentaris | 37 | 2006-10-01 | 2018-03-15 |
| Phase II Study of Perifosine in Patients With Refractory and Relapsed Leukemia perifosine - Leukemia | Phase 2 | Completed | AEterna Zentaris | 19 | 2006-10-01 | 2018-03-14 |
| Phase I Study of Perifosine + Sorafenib for Patients With Advanced Cancers Perifosine, Sorafenib - Renal Cancer, Tumors | Phase 1 | Completed | AEterna Zentaris | 30 | 2006-10-01 | 2014-02-19 |
| Perifosine in Patients With Relapsed/Refractory Waldenstrom's Macroglobulinemia Perifosine - Waldenstrom's Macroglobulinemia | Phase 2 | Completed | Dana-Farber Cancer Institute | 37 | 2006-09-01 | 2017-12-26 |
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Neoplasms (7) · Multiple Myeloma (4) · Brain Neoplasms (3) · Glioma (3) · Kidney Neoplasms (3) · Leukemia (3) · Sarcoma (3) · Astrocytoma (2) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Colonic Neoplasms (2) · Glioblastoma (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Lymphoma (2) · Myelodysplastic-Myeloproliferative Diseases (2)
AEterna Zentaris (22) · National Cancer Institute (NCI) (7) · Memorial Sloan Kettering Cancer Center (3) · NCIC Clinical Trials Group (2) · University Health Network, Toronto (2) · Andrew B Lassman, MD (1) · Dana-Farber Cancer Institute (1) · Daphne Friedman (1) · Eastern Cooperative Oncology Group (1) · M.D. Anderson Cancer Center (1) · University of Wisconsin, Madison (1)
United States (29) · Canada (5) · Czechia (1) · Ireland (1) · Israel (1) · Russia (1) · Slovakia (1) · South Korea (1) · Spain (1)
Ira Dunkel, MD (2) · Paul Richardson, MD (2) · Andrew B. Lassman, MD (1) · Andrzej J Jakubowiak, MD, PhD (1) · Athanassios Argiris, MD (1) · Craig Henderson, MD (1) · Daniel Cho, MD (1) · Daphne Friedman, MD (1) · David S. Hong, MD (1) · David Spigel, MD (1) · Dejka Araujo, MD (1) · Donald S. Ernst, MD, FRCPC (1) · Ed Cullen, PhD (1) · Edward A. Sausville, MD, PhD (1)
PMID 22419878, PMID 16034524, PMID 16138006, PMID 16528479, PMID 16760642, PMID 17278891, PMID 17458693, PMID 20103671, PMID 21969495, PMID 21990396, PMID 22640031, PMID 23443507, PMID 27649927
N01CM17101 (1), N01CM17104 (1), P30CA008748 (1), P30CA014520 (1), U01CA069856 (1)