92 completed, 11 terminated, 5 unknown, 3 recruiting. 33 Phase 4, 31 Phase 2, 23 Not applicable, 18 Phase 1, 14 Phase 3.
Follow Zofran: new trials by email Literature Review of Zofran trials Research Report on Zofran
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg - Postoperative Nausea and Vomiting | Phase 4 | Recruiting | Faisalabad Medical University | 264 | 2026-09-01 | 2026-09-04 |
| Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy Ondansetron Intraperitoneal Lavage, Saline Intraperitoneal Lavage - Postoperative Pain Management, Laparoscopic Cholecystectomy | Phase 4 | Active not recruiting | Instituto Mexicano del Seguro Social | 40 | 2025-12-01 | 2025-12-16 |
| Ondansetron vs. Dexamethasone for Postoperative Nausea Placebo (Normal Saline), Ondansetron (Zofran), Dexamethasone - Postoperative Nausea and Vomiting (PONV) | Phase 4 | Completed | Hafiz Muhammad Hamza | 105 | 2025-03-20 | 2025-06-17 |
| The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics Metoclopramide and Vitamin B6, Vitamin B6, Ondansetron - Vomiting | Phase 2 / Phase 3 | Completed | University of Baghdad | 250 | 2024-01-30 | 2024-04-30 |
| Ondansetron and Gabapentin in Preventing Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy Ondansetron 8mg, Gabapentin - Post Operative Nausea and Vomiting, Sleeve Gastrectomy | Phase 3 | Completed | Tanta University | 100 | 2022-10-01 | 2025-04-17 |
| Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy Capsaicin Topical Cream, Metoclopramide, Ondansetron - Hyperemesis Gravidarum, Nausea Gravidarum | Phase 2 | Completed | Women and Infants Hospital of Rhode Island | 30 | 2022-05-24 | 2024-02-07 |
| Inhaled Isopropyl Alcohol for Treatment of Nausea Inhaled Isopropyl Alcohol, Oral Ondansetron, Inhaled Placebo - Vomiting, Nausea | Phase 2 / Phase 3 | Recruiting | State University of New York at Buffalo | 84 | 2022-04-20 | 2026-09-24 |
| T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers IL-2 (Aldesleukin), Cyclophosphamide, KK-LC-1 TCR - Kita-kyushu Lung Cancer Antigen 1, Human | Phase 1 | Terminated | National Cancer Institute (NCI) | 36 | 2022-03-08 | 2025-12-02 |
| PROUD Study - Preventing Opioid Use Disorders Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin - Anesthesia, Opioid Use | Phase 4 | Terminated | Emory University | 57 | 2021-05-17 | 2023-06-22 |
| Examining the Effect of Ondansetron on Bowel Prep Success Ondansetron - Abdominal Pain, Inflammatory Bowel Diseases | Phase 4 | Completed | State University of New York - Downstate Medical Center | 41 | 2021-01-01 | 2025-10-15 |
| Palonosetron Versus Ondansetron for PONV Prevention in Patients Undergoing ERCP Ondansetron 4 mg, Palonosetron 75 mcg - Antiemetic, Postoperative Nausea and Vomiting | Phase 4 | Unknown | Theodor Bilharz Research Institute | 90 | 2020-10-24 | 2020-10-06 |
| PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers PLX038, Rucaparib, Ondansetron - Small Cell Lung Cancer, Extra-Pulmonary Small Cell Carcinomas | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 10 | 2020-04-08 | 2026-08-26 |
| Cisplatin Disposition and Kidney Injury Granisetron, Ondansetron, Palonosetron - Nephrotoxicity | Phase 3 | Active not recruiting | University of Colorado, Denver | 45 | 2019-11-15 | 2026-09-17 |
| Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritis Ondansetron Oral Solution, Oral Placebo - Acute Gastroenteritis, Viral Illness | Phase 3 | Completed | University of Calgary | 1030 | 2019-09-14 | 2025-04-25 |
| The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis Methotrexate, Ondansetron, Folic/folinic acid - Juvenile Idiopathic Arthritis | Not applicable | Completed | University of British Columbia | 52 | 2019-08-02 | 2025-06-29 |
| Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With Zofran Bremelanotide, Zofran, Placebo - Nausea | Phase 1 | Completed | AMAG Pharmaceuticals, Inc. | 228 | 2019-06-17 | 2022-04-04 |
| Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and Dyspepsia Ondansetron 8mg, Placebo - Indigestion, Diabetes Mellitus | Phase 2 | Recruiting | Mayo Clinic | 150 | 2019-04-02 | 2026-05-04 |
| Ondansetron and Dexamethasone for Prevention of PDPH, Nausea, and Vomiting Ondansetron 8mg, Dexamethasone, Saline - Postdural Puncture Headache, Postoperative Nausea and Vomiting | Phase 4 | Completed | Minia University | 150 | 2018-10-01 | 2025-07-18 |
| Effect of Ketorolac on Post Adenotonsillectomy Pain Ketorolac, Standard of Care - Obstructive Sleep Apnea | Phase 4 | Completed | Emory University | 63 | 2018-07-19 | 2024-09-19 |
| Pharmacogenomics and Post-Operative Nausea and Vomiting Granisetron, Ondansetron - Postoperative Nausea | Phase 4 | Completed | Mayo Clinic | 92 | 2018-05-02 | 2020-10-28 |
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Vomiting (38) · Nausea (29) · Postoperative Nausea and Vomiting (23) · Alcoholism (7) · Gastroenteritis (6) · Pain, Postoperative (6) · Breast Neoplasms (5) · Leukemia, Myeloid, Acute (5) · Multiple Myeloma (5) · Neoplasms (5) · Burkitt Lymphoma (4) · Diarrhea (4) · Lymphoma, Large B-Cell, Diffuse (4) · Lymphoma, Non-Hodgkin (4) · Pain (4)
Merck Sharp & Dohme LLC (6) · National Cancer Institute (NCI) (5) · Stanford University (5) · M.D. Anderson Cancer Center (4) · University of British Columbia (4) · Bankole Johnson (3) · Copenhagen University Hospital, Rigshospitalet (3) · Par Pharmaceutical, Inc. (3) · University of Colorado, Denver (3) · University of Virginia (3) · Dr. Stephen Freedman (2) · Emory University (2) · Mayo Clinic (2) · St. Justine's Hospital (2) · Theodor Bilharz Research Institute (2)
United States (71) · Canada (12) · Denmark (4) · Pakistan (4) · Egypt (3) · Italy (2) · Mexico (2) · Turkey (Türkiye) (2) · Brazil (1) · Germany (1) · India (1) · Iraq (1) · Israel (1) · Netherlands (1) · Puerto Rico (1)
Bankole Johnson, DSc, MD, PhD (3) · Stephen Freedman, MD (3) · Bankole Johnson, DSc,MD,PhD (2) · Christian Aumais (2) · Emily Stern, PhD (2) · Jocelyn Gravel, MD (2) · Jorge Cortes, MD (2) · Rikke Soennichsen, MD (2) · Sajid B Soofi, MD (2) · Scott M Norberg, D.O. (2) · Zulfiqar Bhutta, MD (2) · Abla El Hadidy, PhD (1) · Adil E Bharucha, MD (1)
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