9 completed, 1 terminated, 1 unknown. 6 Phase 2, 2 Not applicable, 2 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 5, Unknown 1 |
| Not applicable | 2 | Completed 2 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 1 | Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Uridine: new trials by email Literature Review of Uridine trials Research Report on Uridine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy Orthognathic Surgery, Melatonin 10 MG Oral Tablet, Hydroxycobalamin - Retrognathism, Prognathism | Phase 2 / Phase 3 | Unknown | Universitat Internacional de Catalunya | 220 | 2022-09-30 | 2022-09-13 |
| Clinical and Imaging Trial of Uridine for Veterans With Suicidal Ideation Uridine, Placebo - Suicidal Ideation | Phase 4 | Completed | VA Office of Research and Development | 75 | 2018-04-02 | 2025-08-15 |
| Immunologic Effects of Supplemental Monosaccharide and Nucleoside Derivatives in Patients With Inherited Disorders of Glycosylation N-Acetylglucosamine (GlcNAc), Uridine - PGM3 | Phase 1 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 2 | 2015-06-30 | 2017-07-02 |
| Uridine Adolescent Bipolar Depression Randomized Controlled Trial Uridine, Placebo - Bipolar Disorder, Bipolar Depression | Not applicable | Completed | University of Utah | 62 | 2013-08-01 | 2018-03-12 |
| Oral Uridine for Treatment of Bipolar Depression in Adolescents Uridine - Bipolar Disorder | Phase 2 | Completed | University of Utah | 42 | 2009-05-01 | 2018-03-26 |
| A Study to Assess the Safety, Tolerability and Efficacy of RG2417 in Bipolar I Depression RG2417, Placebo - Bipolar I Depression | Phase 2 | Completed | Repligen Corporation | 180 | 2008-11-01 | 2011-01-17 |
| Effect of Uridine on GABA and High Energy Phosphate Levels in Healthy Volunteers Uridine - Healthy Male Subjects | Phase 1 | Completed | Mclean Hospital | 33 | 2006-11-01 | 2010-12-16 |
| Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression Uridine - Bipolar Depression | Phase 2 | Completed | Repligen Corporation | 80 | 2006-03-01 | 2007-11-09 |
| Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults NucleomaxX, Tenofovir Disoproxil Fumarate - HIV Infections, Lipodystrophy | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 50 | 2005-04-01 | 2017-06-07 |
| Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis amiloride, uridine - Cystic Fibrosis | Not applicable | Completed | FDA Office of Orphan Products Development | 1996-09-01 | 2015-03-25 | |
| Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity ribose, thymidine, uridine - 5'-Nucleotidase Syndrome | Phase 2 | Completed | National Center for Research Resources (NCRR) | 1995-03-01 | 2005-06-24 |
Bipolar Disorder (4) · Rare Diseases (2) · 5-Nucleotidase syndrome (1) · Cystic Fibrosis (1) · Depression (1) · Genetic Diseases, Inborn (1) · HIV Infections (1) · Lipodystrophy (1) · Metabolic Diseases (1) · Metabolism, Inborn Errors (1) · Nutrition Disorders (1) · Prognathism (1) · Respiratory Tract Diseases (1) · Retrognathia (1) · Sensation Disorders (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · Repligen Corporation (2) · University of Utah (2) · FDA Office of Orphan Products Development (1) · Mclean Hospital (1) · National Center for Research Resources (NCRR) (1) · Universitat Internacional de Catalunya (1) · VA Office of Research and Development (1)
United States (8)
Alice L. Yu (1) · David Jacoby, MD, PhD (1) · Douglas G Kondo, M.D. (1) · Douglas Gavin Kondo, MD (1) · Douglas Kondo, MD (1) · Gary Sachs, MD (1) · Grace A. McComsey, MD (1) · Jonathan J Lyons, M.D. (1) · Michael R. Knowles (1) · Pedro Sole, DMD, OMFS (1) · Perry F Renshaw, MD PhD (1)
PMID 17538545, PMID 21486171, PMID 22293126
R01MH058681 (2), R01AI060484 (1)