4 completed, 4 recruiting, 3 not yet recruiting, 2 terminated. 7 Not applicable, 4 Phase 1, 2 Phase 2, 2 Phase 3, 1 Early Phase 1.
Follow tributyrin: new trials by email Literature Review of tributyrin trials Research Report on tributyrin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial Tributyrin, Placebo - Parkinson Disease, Multiple System Atrophy | Phase 1 / Phase 2 | Recruiting | Prabesh Kanel | 15 | 2026-10-01 | 2026-11-05 |
| A Prospective, Single-Arm Clinical Study of a Dietary Supplement for the Prevention of Acute Radiation-Induced Rectal Injury During Neoadjuvant Chemoradiotherapy for Rectal Cancer Tributyrin - Radiotherapy, Radiation-Induced Complications | Not applicable | Recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 23 | 2026-07-01 | 2026-09-03 |
| Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain tributyrin, Placebo - Alzheimer Disease (AD) | Phase 3 | Not yet recruiting | Universidad de Almeria | 156 | 2026-06-01 | 2025-12-18 |
| Effect of Tributyrin Supplementation on Glycemic Control, Inflammation, and Cardiovascular Risk in Patients With Type 2 Diabetes tributyrin, Placebo - Diabete Mellitus | Phase 3 | Not yet recruiting | Ain Shams University | 60 | 2026-03-26 | 2026-03-31 |
| The Metabolic Effects of Oral Tributyrin Administration tributyrin, Control - Healthy Overweight/Obese | Not applicable | Recruiting | University of Aarhus | 12 | 2026-02-20 | 2026-03-16 |
| Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments Tributyrin, Placebo - Parkinson Disease, Parkinson Disease Dementia | Phase 1 / Phase 2 | Recruiting | Prabesh Kanel | 45 | 2025-11-07 | 2025-11-12 |
| A Clinical Trial Investigating the Efficacy and Safety of a Lipase Thera-blend and a Lipase Thera-blend + Tributyrin on Memory in Healthy Adults With Self-reported Memory Problems Lipase Thera-blend, Lipase Thera-blend + tributyrin, Placebo - Self-reported Memory Problems, Memory | Not applicable | Completed | Enzymedica | 90 | 2025-08-25 | 2026-03-31 |
| ButOx Human Trial: An Open Label Prospective Cohort Study to Investigate the Effect of Tributyrin (Butyrate Precursor Molecule) Supplementation on Markers of Calcium Oxalate Nephrolithiasis tributyrin - Urolithiasis | Not applicable | Not yet recruiting | University of British Columbia | 10 | 2025-07-01 | 2025-06-04 |
| Tributyrin: Time Course & Efficacy to Improve Health & Performance CoreBiome, Placebo - Metabolite Concentration, Gut Permeability | Not applicable | Terminated | Florida State University | 4 | 2024-08-19 | 2025-04-13 |
| Tributyrin to Promote Gut Health Among Children Undergoing Hematopoietic Cell Transplantation Tributyrin - Hematopoietic Cell Transplantation (HCT) | Early Phase 1 | Withdrawn | Duke University | 2024-08-01 | 2024-08-15 | |
| A Pharmacokinetic Comparison of Three Butyrate Products Lysine butyrate, Sodium Butyrate, Tributyrin - Gastro-Intestinal Disorder | Not applicable | Completed | The Center for Applied Health Sciences, LLC | 10 | 2024-05-03 | 2024-11-22 |
| Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Tributyrin Supplementation tributyrin - Parkinson Disease | Phase 1 | Terminated | Nicolaas Bohnen, MD, PhD | 18 | 2022-07-01 | 2025-01-23 |
| Fat-induced Release of GLP-1 in Humans Tributyrin, C8-diet oil, Olive oil - Type 2 Diabetes | Not applicable | Completed | Glostrup University Hospital, Copenhagen | 12 | 2013-10-01 | 2014-10-15 |
| Tributyrin in Treating Patients With Refractory Prostate Cancer or Other Solid Tumors chemotherapy, tributyrin - Prostate Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | University of Maryland, Baltimore | 24 | 1995-08-01 | 2019-11-04 |
Parkinson Disease (3) · Alzheimer Disease (1) · Cognitive Dysfunction (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Digestive System Diseases (1) · Inflammation (1) · Insulin Resistance (1) · Kidney Calculi (1) · Multiple System Atrophy (1) · Obesity (1) · Prostatic Neoplasms (1) · Supranuclear Palsy, Progressive (1) · Urolithiasis (1)
Prabesh Kanel (2) · Ain Shams University (1) · Duke University (1) · Enzymedica (1) · Florida State University (1) · Glostrup University Hospital, Copenhagen (1) · Nicolaas Bohnen, MD, PhD (1) · Sixth Affiliated Hospital, Sun Yat-sen University (1) · The Center for Applied Health Sciences, LLC (1) · Universidad de Almeria (1) · University of Aarhus (1) · University of British Columbia (1) · University of Maryland, Baltimore (1)
United States (6) · Canada (2) · China (1) · Denmark (1) · Egypt (1) · Spain (1)
Prabesh Kanel, PhD (2) · David A. Van Echo, MD (1) · David Crowley, MD (1) · Jens J Holst, Professor (1) · Nicolaas I Bohnen, MD, PhD (1)