11 completed, 6 recruiting, 5 not yet recruiting, 5 withdrawn. 16 Phase 4, 8 Phase 2, 6 Not applicable, 6 Phase 3, 2 Phase 1.
Follow Tranexamic Acid (TXA): new trials by email Literature Review of Tranexamic Acid (TXA) trials Research Report on Tranexamic Acid (TXA)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Study: TXA, Anticoagulant, Orthopaedic Trauma Tranexamic Acid (TXA) - Patients Undergoing Operative Fixation of Long Bone Fractures Within the Community Medical Centers System | Phase 4 | Not yet recruiting | Arbi Nazarian, MD | 200 | 2027-01-01 | 2026-08-11 |
| The Safety of Simplified Tranexamic Acid Regimen Tranexamic Acid (TXA) - Trauma Coagulopathy, Hemorrhage | Phase 4 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2026-10-01 | 2026-10-09 |
| Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes Sodium Bicarbonate (NaHCO3), Warmed lignocaine, Hyaluronidase Injection - Dermatochalasis of Upper Eyelid, Blepharoplasty | Phase 3 | Not yet recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 80 | 2026-08-01 | 2026-08-03 |
| The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma Tranexamic acid (TXA), Placebo - Subdural Hematoma | Phase 3 | Recruiting | Unity Health Toronto | 130 | 2026-05-20 | 2026-05-29 |
| Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty Tranexamic acid (TXA), Placebo - Knee Arthropathy | Not applicable | Not yet recruiting | NYU Langone Health | 350 | 2026-05-01 | 2026-03-27 |
| Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction Tranexamic Acid (TXA), Placebo - ACL Injury, ACL Tears | Phase 4 | Withdrawn | Campbell Clinic | 2026-04-01 | 2026-03-03 | |
| Study the Anti-inflammatory Effect of Tranexamic Acid When Used in Anterior Cruciate Ligament Reconstruction. Tranexamic Acid (TXA), Placebo (NaCl 0,9%) - ACL Reconstruction, Hemarthrosis | Phase 4 | Not yet recruiting | Chirec | 60 | 2026-01-20 | 2026-01-12 |
| Effect of TXA on Reducing Bruising After Filler Injection Hyaluronic Acid (HA), Tranexamic Acid (TXA), Saline (placebo) - Facial Filler Injections, Hyaluronic Acid | Phase 2 | Recruiting | University of Wisconsin, Madison | 40 | 2025-12-05 | 2026-07-23 |
| BAR-TAX - Tranexamic Acid in Bariatric Surgery. Tranexamic Acid (TXA) - Bariatric Surgery, Bariatric Patients | Not applicable | Active not recruiting | Santa Maria Hospital - GVM Care & Research | 1000 | 2025-12-01 | 2026-02-12 |
| Tranexamic Acid : Nebulization vs IV Route for Hemoptysis Tranexamic Acid (TXA) - Hemoptysis, NEBULIZATION | Phase 2 / Phase 3 | Completed | University of Health Sciences Lahore | 172 | 2025-08-01 | 2025-11-28 |
| Oral Melatonin Versus Oral Tranexamic Acid in the Management of Melasma Melatonin tablet, Tranexamic Acid (TXA) - Melasma (Facial Melasma) | Phase 2 | Enrolling by invitation | Hina Malik | 160 | 2025-06-28 | 2025-09-11 |
| ROLE OF PROPHYLACTIC TRANEXAMIC ACID IN PREVENTION OF POST-PARTUM HEMORRHAGE IN ELLSCS Tranexamic Acid (TXA), Placebo - Post Partum Hemorrhage | Phase 1 | Not yet recruiting | Patel Hospital, Pakistan | 104 | 2025-06-01 | 2025-06-04 |
| Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score Tranexamic Acid (TXA), Tranexamic Acid - Blood Loss, Surgical | Early Phase 1 | Recruiting | Assiut University | 90 | 2025-01-29 | 2025-01-29 |
| Efficacy of Tranexamic Acid Reducing Blood Loss During Maxillofacial Trauma Surgery Tranexamic Acid (TXA), Normal saline - Hemoglobin Level Measurement, Blood Loss During Surgery | Phase 2 | Completed | Nishtar Medical University | 60 | 2025-01-01 | 2026-02-06 |
| Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma Tranexamic Acid (TXA), melatonin (Circadin), Placebo - Melasma, Treatment Outcome | Phase 4 | Active not recruiting | Thammasat University | 75 | 2024-11-12 | 2025-06-24 |
| Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children Low Titer Group O Whole Blood (LTOWB), Placebo, Tranexamic Acid (TXA) - Hemorrhagic Shock, Trauma Injury | Phase 3 | Recruiting | Philip Spinella | 1000 | 2024-11-01 | 2026-09-17 |
| Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study. Tranexamic Acid (TXA) - Healthy Participants | Phase 4 | Completed | University of British Columbia | 110 | 2024-03-30 | 2026-10-08 |
| Evaluating the Effect of Tranexamic Acid on the Clinical Outcomes in Patients With Traumatic Brain Injury Tranexamic Acid (TXA), Normal saline - Traumatic Brain Injury | Phase 1 / Phase 2 | Unknown | Mansoura University | 90 | 2024-03-25 | 2024-05-10 |
| A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement fibrin sealant, Tranexamic Acid (TXA) - Osteo Arthritis of the Knee | Phase 4 | Completed | Singapore General Hospital | 78 | 2024-01-01 | 2026-03-06 |
| Comparison of Single-Dose Tranexamic Acid Vs. Placebo in Ovarian Cancer Surgery Tranexamic Acid (TXA), Placebo - Ovarian Cancer, Perioperative Blood Loss | Not applicable | Completed | Sheikh Zayed Medical College | 372 | 2023-07-12 | 2025-03-19 |
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Hemorrhage (7) · Blood Loss, Surgical (2) · Hip Fractures (2) · Melanosis (2) · Osteoarthritis (2) · Postpartum Hemorrhage (2) · Accidental Injuries (1) · Anterior Cruciate Ligament Injuries (1) · Arthritis (1) · Brain Injuries, Traumatic (1) · COVID-19 (1) · Cutis Laxa (1) · Encephalocele (1) · Hemarthrosis (1) · Hematoma, Subdural (1)
NYU Langone Health (2) · Southwest Hospital, China (2) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (1) · Arbi Nazarian, MD (1) · Assiut University (1) · Baylor College of Medicine (1) · Campbell Clinic (1) · Chirec (1) · Duke University (1) · Emory University (1) · Gregory M Georgiadis MD (1) · Hina Malik (1) · Leading BioSciences, Inc (1) · Mansoura University (1) · Mayo Clinic (1)
United States (18) · Canada (5) · Pakistan (5) · China (3) · Egypt (2) · Belgium (1) · Hong Kong (1) · Italy (1) · Singapore (1) · Thailand (1)
Anna Cohen-Rosenblum, MD, MSc (1) · Anson Chun Long Wu (1) · Anton Chau, MD MMSc (1) · Antonio Braun, MD (1) · Arbi Nazarian, MD (1) · Assoc. Prof. Premjit Juntongjin, MD (1) · Azmi Rahman (1) · Brandon Yuan, MD (1) · Brian Burnikel, MD (1) · Clifford K Boese, MD (1) · Daniel Cho, MD, PhD (1) · Denis Snegovskikh, MD (1) · Dr. Saima Munir, FCPS (OMFS) (1) · Gregory M Georgiadis, MD (1) · Kainat Usman (1)
PMID 23592025, PMID 23917458, PMID 24257657, PMID 26559015, PMID 30604058, PMID 35076931, PMID 35210348, PMID 36410494, PMID 38830735, PMID 39158894, PMID 39898869, PMID 42267805