57 completed, 16 recruiting, 15 unknown, 7 active not recruiting. 58 Not applicable, 4 Phase 3, 4 Phase 4, 1 Phase 2.
Follow Total knee arthroplasty: new trials by email Literature Review of Total knee arthroplasty trials Research Report on Total knee arthroplasty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty Total knee arthroplasty - Knee Osteoarthritis | Not applicable | Not yet recruiting | Loyola University | 96 | 2027-01-01 | 2026-08-27 |
| Daycase Hip and Knee Arthroplasty in Møre and Romsdal Trial Total Hip Arthroplasty, Total Knee Arthroplasty, Unicondylar knee artrhoplasty - Knee Osteoarthritis, Hip Osteoarthritis | Not yet recruiting | Helse Møre og Romsdal HF | 300 | 2026-10-01 | 2026-09-22 | |
| Evaluation of 5-year Survival and Clinical Outcomes in Patients Undergoing Total Knee Arthroplasty With a Polyethylene Tibial Component Total knee arthroplasty - Prosthesis Survival, Arthropathy of Knee | Not applicable | Recruiting | Istituto Ortopedico Rizzoli | 78 | 2026-05-13 | 2026-06-23 |
| Persona SoluTion PPS Femur PMCF Total knee arthroplasty - Rhematoid Arthritis, Osteo Arthritis of the Knee | Enrolling by invitation | Zimmer Biomet | 200 | 2026-02-26 | 2026-10-06 | |
| Partial vs Total Knee Replacement for Medial Knee Osteoarthritis: a Prospective Randomized Controlled Study unicompartmental knee arthroplasty, total knee arthroplasty - Medial Knee Osteoarthritis | Not applicable | Not yet recruiting | Medical University of Graz | 102 | 2026-01-01 | 2025-12-02 |
| MultiCenter IDE Study of the PEEK-OPTIMA™ Femoral Component vs a CoCr Alloy TKA Femoral Component of Similar Design Total Knee Arthroplasty - Knee Osteoarthritis | Not applicable | Recruiting | Maxx Orthopedics Inc | 200 | 2026-01-01 | 2026-06-26 |
| Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty total knee arthroplasty - Knee Osteoarthristis, Knee Replacement Arthroplasty | Not applicable | Recruiting | Elsan | 170 | 2025-12-24 | 2026-03-04 |
| Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System Total Knee Arthroplasty - Knee Osteoarthristis, Total Knee Anthroplasty | Recruiting | Maxx Orthopedics Inc | 300 | 2025-11-01 | 2026-06-26 | |
| Functional Impact at 12 Months Post-op of Posterior Cruciate Ligament Conservation During Robotic-assisted Surgery (MAKO) for Total Knee Replacement. Total knee arthroplasty - Knee Arthroplasty, Total | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nīmes | 300 | 2025-10-10 | 2026-03-27 |
| Pain Profile and Pain Medication Use After THA and TKA total hip arthroplasty, total knee arthroplasty - Pain, Postoperative | Withdrawn | Duke University | 2025-08-01 | 2025-06-15 | ||
| ROSA® Knee System V1.5 Pilot Study Total Knee Arthroplasty - Knee Arthroplasty, Total, Robotic Surgical Procedures | Not applicable | Completed | Zimmer Biomet | 40 | 2025-02-25 | 2026-02-27 |
| Comparison of Restricted Versus Unrestricted Kinematic Alignment in 1ry TKA Total knee arthroplasty - Osteoarthritis (OA) of the Knee, Total Knee Anthroplasty | Not applicable | Not yet recruiting | Assiut University | 80 | 2025-02-01 | 2024-12-19 |
| Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? laparoscopic sleeve gastrectomy, total knee arthroplasty - Osteoarthritis of Knee, Arthroplasties, Knee Replacement | Not applicable | Not yet recruiting | Memorial University of Newfoundland | 142 | 2025-02-01 | 2025-01-30 |
| Simulation-Based Preoperative Education in Total Knee Arthroplasty Simulation-Based Preoperative Education, Standard Verbal Preoperative Education, Total Knee Arthroplasty - Total Knee Arthroplasty, Surgical Fear and Worrying | Not applicable | Completed | Nermin Ocaktan | 48 | 2025-01-15 | 2026-05-12 |
| Hi-Fatigue G Bone Cement Retrospective Study Total knee arthroplasty, Total Hip arthroplasty - Total Hip and Knee Arthroplasties | Recruiting | Zimmer Biomet | 90 | 2024-11-19 | 2025-12-02 | |
| An Artificial Intelligence-based Approach in Total Knee Arthroplasty: From Inflammatory Responses to Personalized Medicine Total Knee Arthroplasty, Multifaceted diagnostic assessments, Follow-ups - Knee Osteoarthritis | Not applicable | Recruiting | Fondazione Policlinico Universitario Campus Bio-Medico | 197 | 2024-10-14 | 2026-03-04 |
| Evaluation of the Effect of Central Sensitivity on Pain and Functional Status After Total Knee Joint Replacement Surgery Total knee arthroplasty - Central Sensitisation, Postoperative Pain | Unknown | Istanbul University | 80 | 2024-08-12 | 2024-08-15 | |
| Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis Total Knee arthroplasty - Total Knee Arthroplasty | Not applicable | Recruiting | FH ORTHO | 92 | 2024-02-01 | 2025-06-19 |
| A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension Total Knee Arthroplasty - Knee Osteoarthritis | Recruiting | Canary Medical | 626 | 2023-09-12 | 2025-02-05 | |
| Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty) Total Knee Arthroplasty - Knee Pain Chronic, Osteoarthritis, Knee | Active not recruiting | Zimmer Biomet | 760 | 2023-06-28 | 2026-10-19 |
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Osteoarthritis, Knee (38) · Osteoarthritis (31) · Arthritis, Rheumatoid (11) · Arthritis (9) · Pain, Postoperative (5) · Joint Diseases (4) · Osteonecrosis (4) · Osteoarthritis, Hip (3) · Arthritis, Juvenile (2) · Musculoskeletal Diseases (2) · Obesity (2) · Patient Satisfaction (2) · Prosthesis Failure (2) · Acute Kidney Injury (1) · Arthralgia (1)
Zimmer Biomet (6) · University of Salford (4) · DePuy Orthopaedics (3) · Istituto Ortopedico Rizzoli (3) · Pamukkale University (3) · Aesculap AG (2) · Cincinnati Sportsmedicine Research and Education Foundation (2) · Gulhane Training and Research Hospital (2) · Heekin Orthopedic Research Institute (2) · Maxx Orthopedics Inc (2) · Medical University of Graz (2) · Navamindradhiraj University (2) · Northern Orthopaedic Division, Denmark (2) · Peking University Third Hospital (2) · Zimmer, GmbH (2)
United States (28) · Turkey (Türkiye) (11) · Canada (7) · France (7) · United Kingdom (7) · Germany (5) · Spain (5) · China (4) · Italy (4) · Thailand (4) · Austria (3) · Belgium (3) · Denmark (3) · Netherlands (3) · Norway (2)
Asit Shah, MD, PhD (2) · Frank R Noyes, MD (2) · R. David Heekin, M.D. (2) · Satit Thiengwittayaporn, M.D. (2) · Aasis Unnanuntana, M.D. (1) · Amir Kamali (1) · Anders Odgaard, Consultant (1) · Andrey Gritsyuk, PhD (1) · Anners Lerdal, PhD (1) · Anthony Adili, MD, P.Eng, FRCSC (1) · Arzu Erden (1) · Assem Mohamed Mahmoud Ahmed, MD (1)
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