5 completed, 2 terminated, 2 unknown, 1 active not recruiting. 11 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 5, Terminated 2, Unknown 2, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Terminated 1 |
Follow TBI: new trials by email Literature Review of TBI trials Research Report on TBI
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome Biospecimen Collection, Bone Marrow Aspiration, Busulfan - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 66 | 2023-03-15 | 2026-07-30 |
| Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia VP16, TBI, Thiotepa - Acute Lymphoblastic Leukaemia | Phase 2 / Phase 3 | Recruiting | St. Anna Kinderkrebsforschung | 1800 | 2013-04-01 | 2026-09-04 |
| Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission thiotepa, cyclophosphamide, tacrolimus - B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 146 | 2007-03-01 | 2019-08-07 |
| ALL-SCT BFM International- HSCT in Children and Adolescents With ALL VP16, TBI, VP16, ATG - Lymphoblastic Leukemia, Acute, Childhood; | Phase 3 | Unknown | St. Anna Kinderkrebsforschung | 405 | 2007-01-01 | 2015-06-26 |
| Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501) Single Umbilical Cord Blood Unit Transplant, Double Umbilical Cord Blood Unit Transplant, Total Body Irradiation - Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia | Phase 3 | Completed | Medical College of Wisconsin | 224 | 2006-12-01 | 2021-10-28 |
| Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia sargramostim, busulfan, cyclophosphamide - Leukemia | Phase 2 / Phase 3 | Terminated | Masonic Cancer Center, University of Minnesota | 12 | 2006-07-26 | 2024-01-29 |
| Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia total-body irradiation, allogeneic hematopoietic stem cell transplantation, cyclophosphamide - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Acute Myeloid Leukemia/Transient Myeloproliferative Disorder | Phase 3 | Completed | Fred Hutchinson Cancer Center | 25 | 2006-01-01 | 2014-10-31 |
| Total-Body Irradiation With or Without Fludarabine Phosphate Followed By Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer Total-Body Irradiation, Fludarabine Phosphate, Mycophenolate Mofetil - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Fred Hutchinson Cancer Center | 87 | 2003-10-01 | 2017-05-15 |
| Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia VP16, TBI, VP16, ATG - Lymphoblastic Leukemia, Acute, Childhood; | Phase 3 | Unknown | St. Anna Kinderkrebsforschung | 400 | 2003-07-01 | 2015-06-26 |
| Stem Cell Transplant for Hemoglobinopathy Busulfan, Fludarabine, ATG, TLI, Busulfan, Cyclophosphamide, ATG, GCSF, Campath, Fludarabine, Cyclophosphamide - Sickle Cell Disease, Thalassemia | Phase 2 / Phase 3 | Completed | Masonic Cancer Center, University of Minnesota | 22 | 2002-06-01 | 2020-02-27 |
| Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia cyclophosphamide, cyclosporine, etoposide - Leukemia | Phase 3 | Terminated | Children's Hospital of Philadelphia | 43 | 1995-10-01 | 2013-10-16 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (7) · Leukemia, Myeloid, Acute (3) · Congenital Abnormalities (2) · Leukemia (2) · Myelodysplastic Syndromes (2) · Anemia, Diamond-Blackfan (1) · Anemia, Sickle Cell (1) · Chromosome 5q Deletion Syndrome (1) · Graft vs Host Disease (1) · Hematologic Neoplasms (1) · Hodgkin Disease (1) · Leukemia, Biphenotypic, Acute (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Leukemia, Myeloid, Chronic-Phase (1)
St. Anna Kinderkrebsforschung (3) · Children's Oncology Group (2) · Fred Hutchinson Cancer Center (2) · Masonic Cancer Center, University of Minnesota (2) · Children's Hospital of Philadelphia (1) · Medical College of Wisconsin (1)
United States (8) · Canada (5) · Australia (4) · Germany (4) · Austria (3) · Italy (3) · Czechia (2) · Denmark (2) · France (2) · Israel (2) · Netherlands (2) · Poland (2) · Slovakia (2) · Sweden (2) · Turkey (Türkiye) (2)
Adriana Balduzzi, MD (1) · Akif Yesilipek, MD Prof (1) · Angela Smith, MD (1) · Anita Lawitschka, Assoc. Prof. MD (1) · Bart Scott (1) · Brenda Sandmaier (1) · Christina Peters Peters, Prof MD PHD (1) · Christina Peters, Prof. MD PhD (1) · Daniel J. Weisdorf, MD (1) · Franco Locatelli, Prof. MD PhD (1) · Heather J Symons (1) · Jacek Toporski, MD (1) · Jacek Wachowiak, MD, Prof. (1) · Jean-Hugues Dalle, Prof. MD (1)
PMID 33242441, PMID 15812540, PMID 21195303, PMID 25753432, PMID 24497539, PMID 25354103, PMID 25605857, PMID 25862561, PMID 26869631, PMID 29189665, PMID 31319153, PMID 32499241, PMID 33332189, PMID 33974585, PMID 37738088, PMID 39602342, PMID 40820816, PMID 40926035, PMID 41259231, PMID 41779961
P01CA078902 (2), K23HL084054 (1), P01CA018029 (1), P01HL036444 (1), P30CA015704 (1), U01HL069294 (1), U10CA098543 (1), U10CA180886 (1), U24CA076518 (1)