10 completed, 1 recruiting, 1 unknown. 7 Phase 2, 3 Phase 1, 2 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 7 |
| Phase 1 | 3 | Completed 3 |
| Not applicable | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Chromosome 5q Deletion Syndrome: new trials by email Literature Review of Chromosome 5q Deletion Syndrome trials Research Report on Chromosome 5q Deletion Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biocollection in MyeloDysplastic Syndrome (P-MDS) description of MDS pzatient cohort - Myelodysplastic Syndromes, Myelodysplastic Anemia | Not applicable | Recruiting | University Hospital, Brest | 150 | 2022-10-19 | 2026-06-25 |
| Haploinsufficiency of the RBM22 and SLU7 Genes in Del(5q) Myelodysplastic Syndromes somatic cytogenetic and genetic characterization - Myelodysplastic Syndromes, Myelodysplastic Syndrome With Isolated Del(5Q) | Unknown | University Hospital, Brest | 100 | 2020-09-30 | 2021-01-08 | |
| WEE1 Inhibitor AZD1775 With or Without Cytarabine in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome Cytarabine, Laboratory Biomarker Analysis, Pharmacological Study - Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome With Isolated Del(5q) | Phase 2 | Completed | Mayo Clinic | 3 | 2017-05-05 | 2019-09-06 |
| Sirolimus and Azacitidine in Treating Patients With High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia That is Recurrent or Not Eligible for Intensive Chemotherapy Sirolimus, Azacitidine - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 57 | 2013-07-08 | 2025-12-10 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Wake Forest University Health Sciences | 16 | 2011-01-01 | 2018-09-07 |
| Bendamustine and Idarubicin in Treating Older Patients With Previously Untreated AML or MDS bendamustine hydrochloride, idarubicin - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 39 | 2010-09-01 | 2017-08-18 |
| Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy sunitinib malate, pharmacological study, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2009-08-01 | 2014-03-17 |
| Clofarabine and Cytarabine in Treating Older Patients With AML or High-Risk MDS clofarabine, cytarabine - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 35 | 2008-11-01 | 2017-07-11 |
| Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome cyclophosphamide, busulfan, tacrolimus - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Not applicable | Completed | Fred Hutchinson Cancer Center | 52 | 2006-12-01 | 2018-01-02 |
| Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia total-body irradiation, allogeneic hematopoietic stem cell transplantation, cyclophosphamide - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Acute Myeloid Leukemia/Transient Myeloproliferative Disorder | Phase 3 | Completed | Fred Hutchinson Cancer Center | 25 | 2006-01-01 | 2014-10-31 |
| Leucovorin for the Treatment of 5 q Minus Syndrome Leucovorin - 5q Minus Syndrome, Myelodysplastic Syndrome | Phase 2 | Completed | National Institutes of Health Clinical Center (CC) | 14 | 1998-04-01 | 2008-03-04 |
Congenital Abnormalities (8) · Leukemia, Myeloid, Acute (8) · Myeloproliferative Disorders (4) · Burkitt Lymphoma (3) · Hodgkin Disease (3) · Intraocular Lymphoma (3) · Leukemia, Lymphocytic, Chronic, B-Cell (3) · Leukemia, Myelomonocytic, Chronic (3) · Lymphoma, B-Cell, Marginal Zone (3) · Lymphoma, Follicular (3) · Lymphoma, Large B-Cell, Diffuse (3) · Lymphoma, Large-Cell, Immunoblastic (3) · Lymphoma, Mantle-Cell (3) · Lymphoma, Non-Hodgkin (3)
Hematologic Diseases (11) · Hemic and Lymphatic Diseases (11) · Bone Marrow Diseases (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Leukemia (8) · Leukemia, Myeloid (8) · Neoplasms (8) · Neoplasms by Histologic Type (8) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Chronic Disease (4) · Disease Attributes (4) · Hemorrhagic Disorders (4) · Neoplasms by Site (4) · Blood Protein Disorders (3)
Methotrexate (3) · Tacrolimus (3) · merphos (3) · Busulfan (2) · Cyclophosphamide (2) · Cyclosporine (2) · Cytarabine (2) · Cytogenetic Analysis (2) · Flow Cytometry (2) · Peripheral Blood Stem Cell Transplantation (2) · Amplified Fragment Length Polymorphism Analysis (1) · Azacitidine (1) · Bendamustine Hydrochloride (1) · Clofarabine (1) · Deferasirox (1)
Fred Hutchinson Cancer Center (4) · National Cancer Institute (NCI) (2) · University Hospital, Brest (2) · Mayo Clinic (1) · National Institutes of Health Clinical Center (CC) (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Wake Forest University Health Sciences (1)
United States (10) · France (2) · Germany (1)
John Pagel (2) · Andrew Rezvani (1) · Bart Scott (1) · John Deeken (1) · Margaret Kasner, MD (1) · Mary Ann Knovich, MD (1) · Nathalie Douet-Guilbert, MD,PhD (1) · Pavan Reddy (1) · Raoul Tibes (1)
P01HL036444 (2), K12CA076930 (1), K23HL084054 (1), P01CA018029 (1), P01CA078902 (1), P30CA015083 (1), P30CA015704 (1), P30CA046592 (1), U01CA121947 (1)