7 unknown, 4 completed, 1 not yet recruiting, 1 terminated. 6 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 2, Unknown 2, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Withdrawn 1 |
Follow Sputum induction: new trials by email Literature Review of Sputum induction trials Research Report on Sputum induction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SPutum Induction and Nebuliser deviCEs for Patients With CF Sputum induction - Cystic Fibrosis (CF), Cystic Fibrosis Lung Disease | Not applicable | Not yet recruiting | Royal Brompton & Harefield NHS Foundation Trust | 30 | 2026-10-01 | 2026-10-19 |
| Longitudinal Preschool Wheeze Biomarker Study Bronchoscopy, with bronchoalveolar lavage and endobronchial biopsy, Skin prick test, Finger prick blood test - Wheezing | Unknown | Imperial College London | 150 | 2024-02-01 | 2024-04-29 | |
| ATP and P2X3 Receptor in Chronic Cough Adenosine triphosphate (ATP) solution inhalation from nebuliser, Inhalational challenge with increasing concentrations of capsaicin solutions, Recording of Cough Count and frequency using the Hyfe Cough Monitor - Cough | Not applicable | Unknown | Imperial College London | 20 | 2023-02-28 | 2023-02-06 |
| Asthma: Phenotyping Exacerbations 3 Spirometry including peak flow, Fractional Exhaled Nitric Oxide (FeNO), Forced Oscillation Technique (FOT) - Asthma Attack | Unknown | University of Nottingham | 100 | 2022-05-09 | 2022-07-06 | |
| Ventilation Heterogeneity Prior to Lung Resection Hyperpolarized 129Xe MRI, Technegas V SPECT, Sputum Induction - Lung Cancer | Unknown | McMaster University | 115 | 2020-01-06 | 2024-01-05 | |
| General Risk Factors and Inflammatory Determinants in Older Patients With Asthma Sputum induction, Blood sample - Asthma, Late-Onset Asthma | Completed | Gerdien Tramper | 90 | 2017-05-08 | 2020-08-14 | |
| Diagnosis of EIB in Young Elite Athletes (13-18 y) EVH test - Exercise Induced Bronchospasm, Athletes | Not applicable | Unknown | Universitaire Ziekenhuizen KU Leuven | 141 | 2017-01-01 | 2021-11-05 |
| Detection of Aspergillus Fumigatus and Sensitization in COPD Patients With Bronchiectasis vs Without Bronchiectasis Sputum induction, Skin prick test, Questionnaires - Chronic Obstructive Pulmonary Disease | Unknown | Wim Janssens | 100 | 2015-01-01 | 2015-08-24 | |
| Non Invasive Evaluation of Bronchial Inflammation in Infants : a Study of the Sputum Cellularity After Hypertonic Saline Induction Sputum induction - Infantile Asthma | Not applicable | Terminated | University Hospital, Rouen | 34 | 2010-06-01 | 2014-09-19 |
| Induced Sputum Versus Bronchoscopy in Smear Negative Pulmonary Tuberculosis Diagnostic techniques in pulmonary tuberculosis - Pulmonary Tuberculosis | Not applicable | Completed | Centre Hospitalier Universitaire Saint Pierre | 160 | 2009-08-01 | 2018-08-03 |
| Utility of Sputum Induction and Novel Technologies to Improve TB Diagnosis in a High HIV Prevalence Primary Care Setting Sputum induction, standard routine expectorated sputum - Tuberculosis | Not applicable | Completed | University of Cape Town | 517 | 2009-08-01 | 2012-12-24 |
| Effect of Symbicort on HAT and HDAC in Sputum Macrophages of COPD Skin Prick Test, Impulse Oscillometry, Exhaled Nitric Oxide - Chronic Obstructive Pulmonary Disease (COPD), Age Matched Healthy Volunteers (Non-smokers) | Phase 4 | Withdrawn | Imperial College London | 2006-04-01 | 2019-08-07 | |
| Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood allergen inhalation, withdrawal of medication, sputum induction - Asthma, Healthy | Unknown | Groningen Research Institute for Asthma and COPD | 20 | 2005-07-01 | 2007-03-21 | |
| TNF-alpha Directed Therapy in Asthma Study drug administration, Tuberculin intradermal skin test, Lung function test for FEV1 - Asthma | Phase 2 | Completed | Imperial College London | 40 | 2001-10-01 | 2023-09-14 |
Asthma (3) · Pulmonary Disease, Chronic Obstructive (2) · Asthma, Exercise-Induced (1) · Bronchiectasis (1) · Chronic Cough (1) · Cough (1) · Cystic Fibrosis (1) · Disease (1) · Hypersensitivity (1) · Infections (1) · Inflammation (1) · Lung Neoplasms (1) · Respiratory Sounds (1) · Tuberculosis (1) · Tuberculosis, Pulmonary (1)
Imperial College London (4) · Centre Hospitalier Universitaire Saint Pierre (1) · Gerdien Tramper (1) · Groningen Research Institute for Asthma and COPD (1) · McMaster University (1) · Royal Brompton & Harefield NHS Foundation Trust (1) · Universitaire Ziekenhuizen KU Leuven (1) · University Hospital, Rouen (1) · University of Cape Town (1) · University of Nottingham (1) · Wim Janssens (1)
United Kingdom (5) · Belgium (3) · Netherlands (2) · Canada (1) · France (1) · South Africa (1)
Dirkje S Postma, prof. MD PhD (1) · Dominique MA Bullens, MD, PhD (1) · GA Tramper, MD, PhD (1) · GJ Braunstahl, MD, PhD (1) · GM de Boer, MD (1) · Ian Adcock, PhD (1) · Inge M Muylle (1) · Jonathan G Peter, MBChB (1) · Kazuhiro Ito, PhD (1) · Kian Fan Chung, MD (1) · Matthew Martin (1) · Parameswaran Nair, MD, PhD (1) · Peter J Barnes, MA DM DSc FRCP (1) · Sejal Saglani, MD (1)
PMID 24429245, PMID 25358760, PMID 26790574, PMID 29908073, PMID 36927754