8 completed, 1 unknown, 1 withdrawn. 5 Phase 4, 1 Early Phase 1, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 5 | Completed 3, Unknown 1, Withdrawn 1 |
| Early Phase 1 | 1 | Completed 1 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Sodium Chloride Symporter Inhibitors: new trials by email Literature Review of Sodium Chloride Symporter Inhibitors trials Research Report on Sodium Chloride Symporter Inhibitors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Diuretic Strategies in Hospitalized Heart Failure Loop Diuretics vs. loop + thiazide diuretics - Heart Failure | Phase 4 | Withdrawn | Stanford University | 2023-07-01 | 2023-04-12 | |
| Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD Spironolactone, Chlortalidone - Renal Insufficiency, Chronic, Cardio-Renal Syndrome | Phase 4 | Unknown | University Hospital Birmingham | 154 | 2014-06-01 | 2018-01-19 |
| ACE Inhibitors Combined With Exercise for Seniors - Pilot Study Exercise, ACE inhibitor + exercise, Thiazide diuretic + exercise - Hypertension, Aging | Completed | University of Florida | 104 | 2014-01-01 | 2017-07-05 | |
| Causal Inference Research of Resistant Hypertension Treatment With Chinese Approach in a Cohort Study Herbs, Antihypertensive drugs - Primary Hypertension, Hypertension, Resistant to Conventional Therapy | Early Phase 1 | Completed | China Academy of Chinese Medical Sciences | 192 | 2013-08-01 | 2016-09-07 |
| Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension Lisinopril, Amlodipine, Hydrochlorothiazide - Essential Hypertension | Not applicable | Completed | The University of Texas Health Science Center, Houston | 42 | 2013-06-01 | 2018-11-15 |
| Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives all approved antihypertensive drugs; all approved statins - Stroke, Transient Ischemic Attack | Phase 4 | Completed | Istituto Auxologico Italiano | 200 | 2013-04-01 | 2024-02-20 |
| Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension GROUP A: Valsartan plus Chlorthalidone, GROUP B: Valsartan, GROUP C: Chlorthalidone - Hypertension | Phase 3 | Completed | Farma de Colombia SA | 124 | 2013-04-01 | 2016-01-26 |
| Diuretics In the Management of Essential Hypertension (DIME) Study Thiazide diuretics, No diuretics - Hypertension | Phase 4 | Completed | Kyoto University | 1130 | 2004-04-01 | 2024-06-14 |
| Benidipine-based Comparison of Angiotensin Receptors, β-blockers, or Thiazide Diuretics in Hypertensive Patients Angiotensin receptor blockers, β-blockers, thiazide diuretics - Cardiovascular Disease | Phase 4 | Completed | Seiji Umemoto, M.D., Ph.D. | 3501 | 2003-05-01 | 2012-02-22 |
| Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events Anti-hypertensive drug treatment - Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy | Completed | Universidade Gama Filho | 92 | 2001-06-01 | 2013-04-22 |
Hypertension (6) · Essential Hypertension (4) · Heart Failure (2) · Hypertension Resistant to Conventional Therapy (2) · Myocardial Infarction (2) · Stroke (2) · Cardio-Renal Syndrome (1) · Cardiovascular Diseases (1) · Dementia (1) · Diabetes Mellitus, Type 2 (1) · Ischemic Attack, Transient (1) · Motor Activity (1) · Renal Insufficiency, Chronic (1)
China Academy of Chinese Medical Sciences (1) · Farma de Colombia SA (1) · Istituto Auxologico Italiano (1) · Kyoto University (1) · Seiji Umemoto, M.D., Ph.D. (1) · Stanford University (1) · The University of Texas Health Science Center, Houston (1) · Universidade Gama Filho (1) · University Hospital Birmingham (1) · University of Florida (1)
United States (3) · Japan (2) · Brazil (1) · China (1) · Colombia (1) · Ecuador (1) · Russia (1) · United Kingdom (1)
Alberto Zanchetti (1) · Gemma Slinn (1) · Ivan Cordovil, MD (1) · Joyce P Samuel, MD, MS (1) · Juan D Romero, MD (1) · Lisheng Liu, MD (1) · Paulo R Benchimol-Barbosa, MD, DSc (1) · Priscilla Campos (1) · Shinichiro Ueda, MB, ChB, PhD (1) · Takao Saruta, MD, PhD (1) · Tara Chang, MD, MS (1) · Thomas Buford, Ph.D. (1) · Toshio Ogihara, MD, PhD (1)
PMID 11904577, PMID 21610513, PMID 22278623, PMID 23985703, PMID 24979303, PMID 25031188, PMID 26490089, PMID 30202211, PMID 30842257, PMID 31995012, PMID 32905623, PMID 36398903
5KL2TR000370 (1)