47 completed, 15 unknown, 10 recruiting, 10 terminated. 32 Phase 3, 25 Phase 2, 25 Phase 4, 9 Not applicable, 6 Phase 1.
Follow Sodium Chloride 0.9%: new trials by email Literature Review of Sodium Chloride 0.9% trials Research Report on Sodium Chloride 0.9%
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SCARFREE-001: Verteporfin for Scar Prevention Verteporfin Injection, Saline injection - Surgical Scar | Phase 2 | Not yet recruiting | Odense University Hospital | 12 | 2026-10-01 | 2026-10-05 |
| Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal Hypertonic sodium chloride 10%, Sodium Chloride 0.9%, Furosemide intravenous solution - Heart Failure, Renal Disease, Chronic | Phase 3 | Not yet recruiting | University of Monastir | 60 | 2026-09-01 | 2026-07-15 |
| Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy Sodium Chloride 0.9%, Dexamethasone, Chloroprocaine Injection [Clorotekal] - Knee Arthroscopy | Phase 3 | Not yet recruiting | CMC Ambroise Paré | 60 | 2026-09-01 | 2026-06-29 |
| Safety and Immunogenicity Study of a Multivalent Gonorrhoea Vaccine LTB-NG6, Sodium Chloride 0.9% - Neisseria Gonorrhea | Phase 1 | Recruiting | LimmaTech Biologics AG | 142 | 2026-08-19 | 2026-09-23 |
| NON-SURGİCAL PERİODONTAL THERAPY WİTH L-ARGİNİNE L-arginine 0.8% subgingival irrigation, Saline 0.9% subgingival irrigation (placebo), Scaling and root planing - Periodontal Disease, Periodontal Diseases | Not applicable | Active not recruiting | Alanya Alaaddin Keykubat University | 60 | 2026-06-01 | 2026-10-23 |
| Intravenous Dexamethasone as an Adjuvant to Dexmedetomidine After Superior Trunk Block for Arthroscopic Shoulder Surgery Dexamethasone, Dexmedetomidine, Sodium Chloride 0.9% - Postoperative Pain | Not applicable | Not yet recruiting | Recep Karakaşoğlu | 70 | 2026-04-25 | 2026-04-13 |
| Comparison of Postoperative Pain After Root Canal Irrigation in Symptomatic Irreversible Pulpitis Dexamethasone, Sodium Chloride 0.9% - Symptomatic Irreversible Pulpitis | Not applicable | Completed | CMH Lahore Medical College and Institute of Dentistry | 72 | 2026-02-28 | 2026-10-22 |
| Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes Arginine hydrochloride, Sodium Chloride 0.9% - Diabetes (DM), Diabetic Ketoacidosis | Phase 1 / Phase 2 | Recruiting | David K Carroll | 60 | 2025-12-19 | 2026-02-12 |
| The Efficacy and Safety of Intramuscular Methylprednisolone in Patients With Hand OsteoArthritis 120mg methylprednisolone acetate, 40mg methylprednisolone acetate, Placebo - Hand Osteoarthritis | Phase 3 | Recruiting | Sint Maartenskliniek | 212 | 2025-10-28 | 2026-01-28 |
| COMPASS - COpenhagen MenoPAuSe Study Triptorelin 11.25 mg, Sodium Chloride 0.9%, Estradiol (E2) - Menopausal Osteoporosis, Bone Markers | Phase 2 | Recruiting | Martin Blomberg Jensen | 192 | 2025-10-02 | 2026-03-02 |
| Study of NG01 Cell Therapy in Secondary Progressive Multiple Sclerosis NG01 - Autologous bone marrow derived human stromal cells, Sodium Chloride 0.9% - Secondary Progressive Multiple Sclerosis (SPMS) | Phase 2 | Not yet recruiting | NeuroGenesis Ltd. | 45 | 2025-10-01 | 2025-05-07 |
| LIDOCRIT : Effect of Continuous Intravenous LIDOcaine on Discomfort in Postoperative CRITical Care Inpatients Lidocaine (drug), Placebo - Post-surgery Critical Incare | Phase 4 | Not yet recruiting | Rennes University Hospital | 246 | 2025-10-01 | 2025-07-04 |
| Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula Biospecimen Collection, Distal Pancreatectomy, Lanreotide - Pancreatic Carcinoma, Pancreatic Neoplasm | Phase 3 | Recruiting | SWOG Cancer Research Network | 274 | 2025-05-09 | 2026-03-31 |
| Interpectoral-pectoserratus Plane Block for Minimally Invasive Aortic Valve Replacement Via Right Anterior Minithoracotomy Levobupivacaine Hydrochloride 0.25 % Injectable Solution, Sodium chloride 0.9% - Analgesic Effect | Phase 4 | Recruiting | Algemeen Ziekenhuis Maria Middelares | 144 | 2024-09-01 | 2024-09-19 |
| Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer Amiodarone Hydrochloride, Saline - Atrial Fibrillation, Esophageal Carcinoma | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 90 | 2024-06-21 | 2026-05-22 |
| IVIG for Infection Prevention After CAR-T-Cell Therapy Immune Globulin Infusion (Human), 10% Solution, Anti-CD19 CAR T Cells Preparation, Saline - Hematologic Malignancies | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 150 | 2024-06-10 | 2026-06-29 |
| Effect of Single-Dose Dexamethasone on Postoperative Pain After Cesarean Section Under Spinal Anesthesia Dexamethasone (IV), Normal Saline 0.9% Infusion Solution - Spinal Anesthesia, Cesarean Section Pain | Phase 4 | Completed | KRL Hospital, Islamabad | 80 | 2024-03-01 | 2026-07-21 |
| Administration Of Calcium Gluconate for The Reduction of Blood Loss During Elective Cesarean Delivery Calcium Gluconate 10%, sodium chloride 0.9% - Elective Cesarean Delivery | Not applicable | Recruiting | Rambam Health Care Campus | 1180 | 2023-11-14 | 2026-07-16 |
| Impact of Topical Tranexamic Acid in Breast Reconstruction Tranexamic Acid, Saline - Breast Cancer | Phase 4 | Terminated | University of California, San Francisco | 23 | 2023-04-20 | 2025-09-29 |
| Peroperative Administration of Tranexamic Acid in Roux-en-Y Gastric Bypass and One-anastomosis Gastric Bypass Tranexamic Acid Injection [Cyklokapron], Sodium chloride 0.9% - Hemorrhage, Bleeding | Phase 3 | Unknown | Franciscus Gasthuis | 1524 | 2022-09-01 | 2022-07-19 |
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Pain, Postoperative (6) · Breast Neoplasms (4) · Heart Failure (4) · COVID-19 (3) · Hemorrhage (3) · Inflammation (3) · ST Elevation Myocardial Infarction (3) · Stroke (3) · Acute Kidney Injury (2) · Atrial Fibrillation (2) · Brain Injuries, Traumatic (2) · Delirium (2) · Esophageal Neoplasms (2) · Iron Deficiencies (2) · Myocardial Infarction (2)
CMC Ambroise Paré (4) · Stem Cell Therapeutics Corp. (3) · University Hospital, Basel, Switzerland (3) · Australian and New Zealand Intensive Care Research Centre (2) · Jazz Pharmaceuticals (2) · Northwestern University (2) · Region Örebro County (2) · 3M (1) · AIDS Malignancy Consortium (1) · Ain Shams University (1) · Alanya Alaaddin Keykubat University (1) · Albina Nowak, MD (1) · Algemeen Ziekenhuis Maria Middelares (1) · Amicus Therapeutics (1) · Baylor College of Medicine (1)
United States (28) · France (15) · Germany (6) · Switzerland (6) · Netherlands (5) · United Kingdom (5) · Australia (4) · Canada (4) · Finland (4) · Israel (4) · Denmark (3) · New Zealand (3) · Norway (3) · Saudi Arabia (3) · Austria (2)
Michael D Hill, MD (2) · Steven C Cramer, MD (2) · Adnan Iqbal, MD (1) · Adrian Corneliu Iancu, M.D, Ph.D (1) · Alan Peaceman, MD (1) · Albina Nowak, MD (1) · Alistair D Nichol, MD (1) · Anders Opdahl, MD, PhD (1) · Associate Professor Craig French (1) · Bala Venkatesh (1) · Bart Vaes, MD (1) · Bart de Keulenaer (1) · Belaid BB Bouhemad, PU-PH (1)
PMID 26452709, PMID 15920188, PMID 18063608, PMID 18465717, PMID 20554319, PMID 21345435, PMID 21439633, PMID 21559279, PMID 21675055, PMID 21702233, PMID 23075127, PMID 23477634, PMID 23731998, PMID 23872605, PMID 24042386, PMID 24261644, PMID 24588854, PMID 25498484, PMID 25528574, PMID 25662592, PMID 25884605, PMID 26751635, PMID 27324967, PMID 28143564, PMID 28843536, PMID 29466591, PMID 29700898, PMID 29939279, PMID 30132785, PMID 30642657, PMID 30975645, PMID 31042669, PMID 31673391, PMID 32005192, PMID 32171721, PMID 32172314, PMID 32194058, PMID 32247156, PMID 32275191, PMID 32312288, PMID 32335895, PMID 32492040, PMID 33087480, PMID 33253391, PMID 33345865, PMID 33566466, PMID 33648563, PMID 33719606, PMID 33781988, PMID 33846498
2017 (3), 2019 (3), 2015 (2), 2016 (2), 2025 (2), 2008 (1), 2023 (1), N01CN00042 (1), P30CA015083 (1), R01CA276040 (1), UG1CA189974 (1), UM1CA121947 (1)