4 completed, 4 recruiting, 3 terminated, 2 unknown. 5 Phase 2, 4 Not applicable, 4 Phase 4, 3 Phase 1, 1 Phase 3.
Follow Saline (placebo): new trials by email Literature Review of Saline (placebo) trials Research Report on Saline (placebo)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Studies of Insulin and Glucagon Action in the Liver Glucagon, Saline (placebo) - Diabetes (DM) | Phase 1 / Phase 2 | Not yet recruiting | Duke University | 40 | 2026-10-01 | 2026-08-05 |
| Inflammatory Challenge in Human Aggression. Endotoxin (E. coli O:113, Reference Endotoxin), Saline (Placebo) - Intermittent Explosive Disorder | Phase 2 | Recruiting | Ohio State University | 112 | 2026-02-16 | 2026-03-27 |
| Effect of TXA on Reducing Bruising After Filler Injection Hyaluronic Acid (HA), Tranexamic Acid (TXA), Saline (placebo) - Facial Filler Injections, Hyaluronic Acid | Phase 2 | Recruiting | University of Wisconsin, Madison | 40 | 2025-12-05 | 2026-07-23 |
| The Effect of Local Anesthetic Techniques on Hemodynamic Response and Postoperative Sore Throat in Double-Lumen Tubes Tracheo-Spray, Lidocaine Spray on DLT, Saline (Placebo) - Anesthesia, Local, Intubation, Intratracheal | Not applicable | Completed | V.K.V. American Hospital, Istanbul | 60 | 2024-11-06 | 2025-01-13 |
| The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery Tranexamic Acid 100 MG/ML, 0.9%sodium chloride - Surgical Complication | Phase 4 | Recruiting | St. Olavs Hospital | 3000 | 2024-09-18 | 2026-08-14 |
| Protest Trial: TXA vs Saline Tranexamic Acid, Saline (placebo) - Lung Transplant, Complications Surgical | Phase 3 | Enrolling by invitation | Corewell Health West | 94 | 2024-04-16 | 2026-07-21 |
| Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS) human Neural Stem Cells (hNSC), Saline (Placebo) - Amyotrophic Lateral Sclerosis | Phase 2 | Recruiting | Casa Sollievo della Sofferenza IRCCS | 30 | 2024-01-25 | 2024-04-03 |
| The Effect of Intramyometrial Injection of Terlipressin Versus Carbitocin on Hemoglobin and Blood Loss During Open Myomectomy Operations Using Haemostatic Tourniquets: Terlipressin - Myoma | Not applicable | Completed | Wael Elbanna Clinic | 99 | 2022-02-01 | 2024-06-25 |
| The Effects of Low Dose Ketamine on Cardiovascular Function Ketamine, Saline (placebo) - Healthy | Phase 1 | Terminated | University of Texas Southwestern Medical Center | 6 | 2020-11-01 | 2024-05-21 |
| BLADE-PCI Trial (BLADE); PHASE IIB LIPOSOMAL ALENDRONATE STUDY LABR-312, Saline (placebo) - Diabetes Mellitus | Phase 2 | Unknown | BIOrest Ltd. | 270 | 2016-04-01 | 2018-01-11 |
| Use of High Resolution Colonic Manometry in Studying Motility Neostigmine, Glycopyrrolate, Saline (Placebo) - Gastrointestinal Dysfunction | Phase 1 | Withdrawn | James J. Peters Veterans Affairs Medical Center | 2015-10-13 | 2021-09-28 | |
| The Effects of Dexmedetomidine to Postoperative Awakening and Extubation-related Changes in Blood Pressure Dexmedetomidine, Saline (placebo) - Hypertension | Phase 4 | Completed | Tampere University Hospital | 50 | 2013-06-01 | 2017-05-05 |
| Effects of Apelin on the Lung Circulation in Pulmonary Hypertension Apelin, Saline (Placebo) - Pulmonary Arterial Hypertension, Heart Failure | Not applicable | Unknown | Golden Jubilee National Hospital | 63 | 2012-01-01 | 2013-07-15 |
| The Effect of Sodium Thiosulfate Eardrops on Hearing Loss in Patients Who Receive Cisplatin Therapy Insertion of Pressure Equalization (PE) Tubes, Sodium Thiosulfate (STS), Saline (Placebo) - Cancer | Not applicable | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 1 | 2011-08-24 | 2025-05-16 |
| Efficacy Study of Botox to Treat Neuropathic Pain botulinum toxin A - Postherpetic Neuralgia, Nerve Trauma | Phase 4 | Completed | Hospital Ambroise Paré Paris | 29 | 2004-06-01 | 2021-05-05 |
| Scandinavian Intensive Care Unit (ICU) Glutamine Study Glutamine, saline (placebo) - ICU Patients | Phase 4 | Terminated | Scandinavian Critical Care Trials Group | 1000 | 2003-10-01 | 2009-06-17 |
Diabetes Mellitus (2) · Aggression (1) · Amyotrophic Lateral Sclerosis (1) · Critical Illness (1) · Disruptive, Impulse Control, and Conduct Disorders (1) · Heart Failure (1) · Hypertension (1) · Hypertension, Pulmonary (1) · Inflammation (1) · Insulin Resistance (1) · Myoma (1) · Neoplasms (1) · Neuralgia, Postherpetic (1) · Pharyngitis (1) · Pulmonary Arterial Hypertension (1)
BIOrest Ltd. (1) · Casa Sollievo della Sofferenza IRCCS (1) · Corewell Health West (1) · Duke University (1) · Golden Jubilee National Hospital (1) · Hospital Ambroise Paré Paris (1) · James J. Peters Veterans Affairs Medical Center (1) · Ohio State University (1) · Scandinavian Critical Care Trials Group (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · St. Olavs Hospital (1) · Tampere University Hospital (1) · University of Texas Southwestern Medical Center (1) · University of Wisconsin, Madison (1) · V.K.V. American Hospital, Istanbul (1)
United States (7) · Finland (2) · Denmark (1) · Egypt (1) · France (1) · Israel (1) · Italy (1) · Norway (1) · Sweden (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Andrew J Peacock, BSc MPhil MD (1) · Angelo L Vescovi, PhD (1) · Daniel Cho, MD, PhD (1) · David Cognetti, MD (1) · David D'Alessio, MD (1) · Emil F. Coccaro, MD (1) · Jan Wernerman, MD, PhD (1) · Kjersti Ausen, MD PhD (1) · Mark Korsten, MD (1)
PMID 11871952, PMID 26171894, PMID 27158989, PMID 29679676, PMID 29876530, PMID 35305955
2023 (1), R01DK141090 (1), R01MH133925 (1)