4 completed, 3 terminated, 1 recruiting, 1 withdrawn. 4 Phase 2, 2 Phase 3, 2 Phase 4, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 2 | Terminated 1, Withdrawn 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
| Not applicable | 1 | Recruiting 1 |
Follow Sabril: new trials by email Literature Review of Sabril trials Research Report on Sabril
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vigabatrin and Insulin Sensitivity Vigabatrin - NAFLD, Obesity | Phase 2 | Completed | Washington University School of Medicine | 4 | 2021-08-23 | 2025-01-14 |
| Vigabatrin With High Dose Prednisolone Combination Therapy vs Vigabatrin Alone for Infantile Spasm Combination therapy with vigabatrin and prednisolone, Vigabatrin Tablets - Infantile Spasm, West Syndrome | Not applicable | Recruiting | Kullasate Sakpichaisakul | 250 | 2020-05-18 | 2021-08-25 |
| A Study to Assess Cannabidiol Oral Solution With Vigabatrin as Initial Therapy in Participants With Infantile Spasms Cannabidiol Oral Solution, Placebo, Vigabatrin - Infantile Spasm | Phase 3 | Terminated | Radius Pharmaceuticals, Inc. | 2 | 2018-09-05 | 2023-06-07 |
| Prednisolone Versus Vigabatrin in the First-line Treatment of Infantile Spasms Prednisolone, Vigabatrin - Infantile Spasms | Phase 3 | Withdrawn | The Hospital for Sick Children | 2017-09-05 | 2019-11-14 | |
| Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex Early Vigabatrin, Delayed Vigabatrin (Placebo) - Tuberous Sclerosis Complex | Phase 2 | Completed | Martina Bebin | 84 | 2016-12-01 | 2024-08-19 |
| Vigabatrin for Cocaine and Alcohol Dependence Vigabatrin, Placebo - Alcoholism, Cocaine Dependence | Phase 2 | Terminated | University of Pennsylvania | 32 | 2011-04-01 | 2019-09-06 |
| A Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®) Sabril - Adult Refractory Complex Partial Seizures | Phase 4 | Completed | Lundbeck LLC | 65 | 2010-12-01 | 2016-06-07 |
| Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients vigabatrin - Complex Partial Seizures | Phase 4 | Terminated | University of Pennsylvania | 1 | 2010-08-01 | 2017-07-12 |
| Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence Vigabatrin, Placebo, Group therapy - Cocaine Dependence | Phase 2 | Completed | NYU Langone Health | 100 | 2007-04-01 | 2008-04-11 |
Spasms, Infantile (3) · Cocaine-Related Disorders (2) · Seizures (2) · Tuberous Sclerosis (2) · Alcoholism (1) · Behavior, Addictive (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Epilepsy (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Non-alcoholic Fatty Liver Disease (1) · Obesity (1)
University of Pennsylvania (2) · Kullasate Sakpichaisakul (1) · Lundbeck LLC (1) · Martina Bebin (1) · NYU Langone Health (1) · Radius Pharmaceuticals, Inc. (1) · The Hospital for Sick Children (1) · Washington University School of Medicine (1)
United States (6) · Canada (1) · Mexico (1) · Thailand (1)
Carter Snead, MD (1) · Emilia Figueroa, M.D. (1) · John Pollard, MD (1) · Jonathan D Brodie, Ph.D., M.D. (1) · Kullasate Sakpichaisakul, MD (1) · Kyle M Kampman, M.D. (1) · Martina Bebin, MD, MPA (1) · Samuel Klein, MD (1)
PMID 10368073, PMID 10561962, PMID 10565592, PMID 11673582, PMID 12403260, PMID 14734931, PMID 15159460, PMID 15509243, PMID 15541450, PMID 18077226, PMID 19651710, PMID 20608959, PMID 21070215, PMID 22689735, PMID 22859699, PMID 24657009, PMID 26216500, PMID 26280806, PMID 26302697, PMID 27838190, PMID 29105055, PMID 29966811, PMID 31912454, PMID 37638552, PMID 40116235, PMID 4515986, PMID 6308515, PMID 6539199, PMID 8604274, PMID 8681895
P50DA012756 (1), U01NS092595 (1)