11 completed, 1 withdrawn. 12 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 11, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow RIX4414 vaccine: new trials by email Literature Review of RIX4414 vaccine trials Research Report on RIX4414 vaccine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Human Challenge With Live-attenuated Rotavirus to Assess Next-generation Rotavirus Vaccines in Africa Rotarix, Trivalent P2-VP8 - Diarrhea, Diarrhea Rotavirus | Phase 2 | Completed | Centre for Infectious Disease Research in Zambia | 720 | 2021-04-15 | 2025-05-15 |
| Mixed Schedule Study of Live Oral Rotavirus Vaccines and Trivalent P2-VP8 Subunit Rotavirus Vaccine RV3-BB, Trivalent P2-VP8, Rotarix - Rotavirus Vaccine | Phase 2 | Completed | PATH | 850 | 2021-02-22 | 2022-11-29 |
| Study of BBIL's ROTAVAC® and ROTAVAC 5CM Vaccines in Zambia ROTAVAC®, ROTAVAC 5D, Rotarix® - Diarrhea, Diarrhea Rotavirus | Phase 2 / Phase 3 | Completed | Centre for Infectious Disease Research in Zambia | 450 | 2019-01-22 | 2020-12-19 |
| Baby Vaccine Study (Sched3) DTaP/IPV/Hib vaccine, 13 valent Pneumococcal Conjugate Vaccine, Rotavirus vaccine - Infectious Diseases | Phase 2 | Completed | University of Oxford | 189 | 2015-08-01 | 2021-09-20 |
| Study of GlaxoSmithKline Biologicals' GSK2202083A Vaccine in Healthy Infants GSK2202083A vaccine, Prevenar 13®, Infanrix hexa™ - Tetanus, Hepatitis B | Phase 2 | Completed | GlaxoSmithKline | 480 | 2010-05-17 | 2018-08-20 |
| Study of a Birth Dose of GlaxoSmithKline Biologicals' 251154 Vaccine 251154 vaccine, Infanrix hexa™, Synflorix™ - Infections, Rotavirus | Phase 2 | Withdrawn | GlaxoSmithKline | 2010-04-01 | 2015-03-27 | |
| A Study of a Quadrivalent Meningococcal Tetanus Protein Conjugate Vaccine in Infants and Toddlers Quadrivalent Meningococcal Polysaccharide (A, C, Y, and W-135) Tetanus Protein Conjugate, Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus B Conjugate (Tetanus Toxoid Conjugate) Vaccine Combined (DTaP-IPV/Hib combined), M-M-RII-Measles, Mumps, and Rubella Virus Vaccine Live - Meningitis, Meningococcal Infection | Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 580 | 2009-12-16 | 2022-03-28 |
| A Dose-escalating Study to Evaluate the Immunogenicity and Safety of Rotavin-M1 Vaccine in Healthy Infants Rotarix - Diarrhea, Fever | Phase 2 | Completed | National Institute of Hygiene and Epidemiology, Vietnam | 200 | 2009-10-01 | 2016-07-04 |
| A Study to Evaluate Immune Response and Safety of Two Doses of GSK Biologicals' HRV Liquid Vaccine in Healthy Infants. Rotarix™, Placebo - Infections, Rotavirus, Rotavirus Vaccines | Phase 2 | Completed | GlaxoSmithKline | 375 | 2007-03-09 | 2020-01-02 |
| A Study of Safety, Reactogenicity and Immunogenicity of HRV Vaccine in HIV Infected Infants in South Africa Rotarix, Placebo, Tritanrix-HB+Hib - Infections, Rotavirus | Phase 2 | Completed | GlaxoSmithKline | 100 | 2005-03-16 | 2020-11-23 |
| Assess Efficacy, Immune Response & Safety of 2 Doses of Oral Live Attenuated HRV Vaccine at Different Viral Concentrations in Healthy Infants Rotarix - Hepatitis B | Phase 2 | Completed | GlaxoSmithKline | 2464 | 2001-01-01 | 2016-09-16 |
| Assess Efficacy, Immune Response & Safety of 2 Doses of Oral Live Attenuated HRV Vaccine in Healthy Infants Rotarix - Infections, Rotavirus | Phase 2 | Completed | GlaxoSmithKline | 405 | 2000-08-01 | 2016-09-16 |
Rotavirus Infections (4) · Diarrhea (3) · Gastroenteritis (3) · Hepatitis B (2) · Vomiting (2) · Communicable Diseases (1) · Diphtheria (1) · Fever (1) · Haemophilus Infections (1) · Meningitis (1) · Meningococcal Infections (1) · Nausea (1) · Poliomyelitis (1) · Tetanus (1)
GlaxoSmithKline (6) · Centre for Infectious Disease Research in Zambia (2) · National Institute of Hygiene and Epidemiology, Vietnam (1) · PATH (1) · Sanofi Pasteur, a Sanofi Company (1) · University of Oxford (1)
South Africa (2) · Zambia (2) · Canada (1) · France (1) · Germany (1) · Philippines (1) · United Kingdom (1) · United States (1) · Vietnam (1)
Anh D Dang, PhD. (1) · Matthew D Snape (1) · Niraj Rathi, MD (1) · Roma Chilengi, MD (1) · Stanley Cryz, PhD (1) · Thiem D Vu, MD., PhD. (1)
PMID 16394298, PMID 22520120, PMID 33109390, PMID 33428870, PMID 35144847
2015 (2)