12 completed. 12 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 12 |
| Phase 1 | 1 | Completed 1 |
Follow rilonacept: new trials by email Literature Review of rilonacept trials Research Report on rilonacept
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pilot Study of KPL-914 in Recurrent Pericarditis KPL-914 - Recurrent Pericarditis | Phase 2 | Completed | Kiniksa Pharmaceuticals (UK), Ltd. | 26 | 2018-01-24 | 2021-05-27 |
| Cold Contact Urticaria Treatment With Rilonacept Rilonacept, Placebo - Cold Contact Urticaria | Phase 2 | Completed | Charite University, Berlin, Germany | 20 | 2015-01-01 | 2018-07-17 |
| A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis Mycophenolate mofetil, Prednisolone, Rilonacept - Alcoholic Hepatitis | Phase 2 | Completed | Southern California Institute for Research and Education | 4 | 2014-12-01 | 2025-06-12 |
| Rilonacept for Deficiency of the Interleukin-1 Receptor Antagonist (DIRA) Rilonacept - DIRA | Phase 2 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 6 | 2013-02-12 | 2017-10-16 |
| Inflammation in Chronic Kidney Disease and Cardiovascular Disease - The Role of Genetics and Interleukin-1 Receptor Antagonist (IL-1ra) Rilonacept, Placebo - Chronic Kidney Disease, Cardiovascular Disease | Phase 2 | Completed | VA Office of Research and Development | 15 | 2013-01-01 | 2019-10-01 |
| IL1-TRAP, Rilonacept, in Systemic Sclerosis Rilonacept, Placebo - Scleroderma, Systemic Sclerosis | Phase 1 / Phase 2 | Completed | Boston University | 24 | 2011-12-01 | 2018-05-01 |
| Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) rilonacept - Muckle-Wells Syndrome, Schnitzler Syndrome | Phase 2 | Completed | Charite University, Berlin, Germany | 10 | 2009-01-01 | 2012-05-31 |
| Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young Adults Rilonacept - Juvenile Idiopathic Arthritis | Phase 2 | Completed | Montefiore Medical Center | 71 | 2008-11-01 | 2015-12-11 |
| Rilonacept for Treatment of Familial Mediterranean Fever (FMF) Rilonacept, Placebo - Familial Mediterranean Fever | Phase 2 | Completed | The Cleveland Clinic | 14 | 2008-08-01 | 2013-02-11 |
| Study of the Safety and Effectiveness of Rilonacept for the Prevention of Gout Flares Rilonacept, Placebo (for Rilonacept) - Gout | Phase 2 | Completed | Regeneron Pharmaceuticals | 83 | 2007-11-01 | 2017-05-02 |
| Rilonacept to Improve Artery Function in Patients With Atherosclerosis Rilonacept, Placebo - Coronary Artery Disease, Atherosclerosis | Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 10 | 2006-12-01 | 2012-04-30 |
| Interleukin-1 Trap to Treat Autoinflammatory Diseases IL-1 Trap - Inflammation, Familial Mediterranean Fever | Phase 2 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 11 | 2004-10-01 | 2014-03-04 |
Inflammation (3) · Cryopyrin-Associated Periodic Syndromes (2) · Familial Mediterranean Fever (2) · Arthritis, Juvenile (1) · Atherosclerosis (1) · Cardiovascular Diseases (1) · Cold Urticaria (1) · Coronary Artery Disease (1) · Fever (1) · Gout (1) · Hepatitis, Alcoholic (1) · Pericarditis (1) · Renal Insufficiency, Chronic (1) · Rheumatoid Arthritis, Systemic Juvenile (1) · Schnitzler Syndrome (1)
Charite University, Berlin, Germany (2) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (2) · Boston University (1) · Kiniksa Pharmaceuticals (UK), Ltd. (1) · Montefiore Medical Center (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Regeneron Pharmaceuticals (1) · Southern California Institute for Research and Education (1) · The Cleveland Clinic (1) · VA Office of Research and Development (1)
United States (10) · Germany (2)
Adriana M Hung, MD MPH (1) · Gina A Montealegre, M.D. (1) · Karoline Krause, MD (1) · Marcus Maurer, MD (1) · Norman T. Ilowite, MD (1) · Philip J Hashkes, MD, MSc (1) · Richard O Cannon, MD (1) · Robert W Simms, MD (1) · Shirletta King-Davis (1) · Timothy R. Morgan, MD (1)
PMID 18668591, PMID 21372003, PMID 22223180, PMID 22583335, PMID 23070486, PMID 24833067, PMID 25147819, PMID 28814674, PMID 30277862, PMID 33229362, PMID 33882846, PMID 36973954
268200700015C-2-0-0 (1), U01AA021886 (1)