6 completed, 2 recruiting, 1 terminated, 1 unknown. 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 5, Terminated 1, Unknown 1, Withdrawn 1 |
Follow Schnitzler Syndrome: new trials by email Literature Review of Schnitzler Syndrome trials Research Report on Schnitzler Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Effectiveness and Safety of Canakinumab in Clinical Use in Patients With Schnitzler's Syndrome Schnitzler Syndrome | Recruiting | Novartis Pharmaceuticals | 10 | 2026-05-13 | 2026-09-03 | |
| Study of the Efficacy and Safety of RPH-104 in Adult Subjects With Schnitzler Syndrome 80 mg RPH-104, Placebo - Schnitzler Syndrome, Urticarial Vasculitis With Monoclonal Immunoglobulin M Component, Schnitzler (Disorder) | Phase 2 | Withdrawn | R-Pharm Overseas, Inc. | 2023-05-01 | 2024-11-15 | |
| AutoInflammatory Disease Alliance Registry (AIDA) No intervention is foreseen by the protocol. - Hereditary Autoinflammatory Diseases, Schnitzler Syndrome | Recruiting | University of Siena | 3500 | 2020-08-06 | 2025-07-10 | |
| Pilot Study of Dapansutrile Capsules in Schnitzler's Syndrome dapansutrile - Schnitzler Syndrome | Phase 2 | Terminated | Olatec Therapeutics, Inc. | 2 | 2018-05-15 | 2024-02-02 |
| Tocilizumab in Patients With Schnitzler's Syndrome Tocilizumab - Schnitzler's Syndrome | Phase 2 | Completed | Karoline Krause | 8 | 2017-07-19 | 2020-02-17 |
| Ilaris® Effects in Schnitzler Syndrome (ILESCH) Canakinumab, Placebo - Schnitzler Syndrome | Phase 2 | Completed | Charite University, Berlin, Germany | 20 | 2011-07-01 | 2018-07-17 |
| Ilaris (Canakinumab) in the Schnitzler Syndrome Ilaris - Schnitzler Syndrome | Phase 2 | Completed | Universitaire Ziekenhuizen KU Leuven | 1 | 2011-05-01 | 2019-07-05 |
| Efficacy and Safety of Canakinumab in Schnitzler Syndrome Canakinumab - Schnitzler Syndrome | Phase 2 | Completed | Radboud University Medical Center | 8 | 2011-01-01 | 2012-05-24 |
| Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Schnitzler Syndrome | Completed | University Hospital, Strasbourg, France | 52 | 2009-07-01 | 2017-09-08 | |
| Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) rilonacept - Muckle-Wells Syndrome, Schnitzler Syndrome | Phase 2 | Completed | Charite University, Berlin, Germany | 10 | 2009-01-01 | 2012-05-31 |
| The Efficacy and Safety of ITF2357 in AIS ITF2357 - Autoinflammatory Syndromes, HIDS | Phase 2 | Unknown | Radboud University Medical Center | 20 | 2006-09-01 | 2007-03-01 |
Arthritis, Juvenile (1) · Behcet Syndrome (1) · Castleman Disease (1) · Cryopyrin-Associated Periodic Syndromes (1) · Hereditary Autoinflammatory Diseases (1) · Marshall syndrome (1) · Paraproteinemias (1) · Scleritis (1) · Spondylarthritis (1) · Uveitis (1) · VEXAS syndrome (1)
Immune System Diseases (11) · Immunoproliferative Disorders (11) · Monoclonal Gammopathy of Undetermined Significance (11) · Paraproteinemias (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2) · Hemic and Lymphatic Diseases (2) · Skin Diseases (2) · Skin Diseases, Genetic (2) · Skin Diseases, Vascular (2) · Skin and Connective Tissue Diseases (2) · Arthritis (1) · Autoimmune Diseases (1) · Blood Protein Disorders (1) · Bone Diseases (1)
canakinumab (3) · dapansutrile (1) · givinostat hydrochloride (1) · rilonacept (1) · tocilizumab (1)
Charite University, Berlin, Germany (2) · Radboud University Medical Center (2) · Karoline Krause (1) · Novartis Pharmaceuticals (1) · Olatec Therapeutics, Inc. (1) · R-Pharm Overseas, Inc. (1) · Universitaire Ziekenhuizen KU Leuven (1) · University Hospital, Strasbourg, France (1) · University of Siena (1)
Germany (4) · Netherlands (3) · Belgium (2) · Italy (2) · Algeria (1) · Australia (1) · Brazil (1) · China (1) · Colombia (1) · Egypt (1) · France (1) · Greece (1) · India (1) · Iran (1) · Japan (1)
Karoline Krause, MD (2) · Anna Simon, MD PhD (1) · Curt Scribner, MD (1) · Dan Lipsker, Pr (1) · Marcus Maurer, MD (1) · Steven Vanderschueren, MD, PhD (1) · Yan Lavrovsky (1)
PMID 22583335, PMID 22901459, PMID 23087179, PMID 33545397, PMID 35463015, PMID 35755024, PMID 35831701, PMID 35899212, PMID 35935379, PMID 36160138, PMID 36881285, PMID 37517110, PMID 38206518, PMID 40175882, PMID 42444147