8 completed, 1 not yet recruiting, 1 unknown. 10 Phase 2, 7 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 8, Not yet recruiting 1, Unknown 1 |
| Phase 1 | 7 | Completed 5, Not yet recruiting 1, Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Pyrimethamine: new trials by email Literature Review of Pyrimethamine trials Research Report on Pyrimethamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combining Latency Reversing Agents to Address the HIV Reservoir Pyrimethamine (PYR), Lenalidomide, Topiramate (drug) - HIV (Human Immunodeficiency Virus), HIV -1 Infection | Phase 1 / Phase 2 | Not yet recruiting | Erasmus Medical Center | 30 | 2026-04-01 | 2026-02-03 |
| Optimizing Reversal of HIV Latency With Combination Therapy Panobinostat 20 MG Oral Capsule, Pyrimethamine 200mg Oral Tablet, Lenalidomide 25 MG Oral Capsule - Hiv | Phase 1 / Phase 2 | Unknown | Erasmus Medical Center | 49 | 2024-04-01 | 2024-02-05 |
| Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa... Chloroquine Phosphate, PfSPZ Challenge, Pyrimethamine - Malaria | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 252 | 2019-05-23 | 2022-07-12 |
| LRAs United as a Novel Anti-HIV Strategy. Valproic Acid, Pyrimethamine - HIV-1-infection | Phase 1 / Phase 2 | Completed | Erasmus Medical Center | 28 | 2018-04-18 | 2021-04-29 |
| Pyrimethamine for the Treatment of Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma pyrimethamine - Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia | Phase 1 / Phase 2 | Completed | Dana-Farber Cancer Institute | 20 | 2010-03-01 | 2023-02-22 |
| SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS) Pyrimethamine - Familial Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Completed | Weill Medical College of Cornell University | 32 | 2009-11-01 | 2017-06-19 |
| Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease) Pyrimethamine, Leucovorin - Gangliosidoses, GM2, Sandhoff Disease | Phase 1 / Phase 2 | Completed | The Hospital for Sick Children | 20 | 2009-08-01 | 2012-02-23 |
| Anti-Malarial Drug Resistance in Cameroon Amodiaquine and Sulphadoxine/Pyrimethamine - Malaria | Phase 2 / Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 755 | 2003-08-01 | 2017-01-12 |
| Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Sulfadiazine, Clarithromycin, Atovaquone - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 100 | 2021-10-28 | |
| Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Pyrimethamine, Leucovorin calcium - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 150 | 2021-11-02 |
Acquired Immunodeficiency Syndrome (4) · HIV Infections (2) · Malaria (2) · Toxoplasmosis, Cerebral (2) · AIDS-Related Complex (1) · Amyotrophic Lateral Sclerosis (1) · Brain Diseases (1) · Encephalitis (1) · Gangliosidoses, GM2 (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Recurrence (1) · Sandhoff Disease (1) · Shock (1) · Tay-Sachs Disease (1) · Toxoplasmosis (1)
Erasmus Medical Center (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Dana-Farber Cancer Institute (1) · London School of Hygiene and Tropical Medicine (1) · The Hospital for Sick Children (1) · Weill Medical College of Cornell University (1)
United States (4) · Netherlands (3) · Canada (1) · Germany (1) · Italy (1) · Mali (1) · Sweden (1)
Casper Rokx, MD PhD (2) · BJ Luft (1) · Chirgwin K (1) · Dale J. Lange, M.D. (1) · JL Vilde (1) · Jennifer Brown, MD, PhD (1) · Joe T Clarke, MD (1) · Luft B (1) · Patrick E Duffy, M.D. (1) · Tokameh Mahmoudi, PhD (1) · Wilfred Mbacham, ScD (1)
2017 (1)