11 active not recruiting, 11 completed, 7 recruiting, 2 terminated. 14 Phase 2, 11 Not applicable, 6 Phase 1, 5 Phase 3.
Follow Proton radiation therapy: new trials by email Literature Review of Proton radiation therapy trials Research Report on Proton radiation therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Proton Therapy for Recurrent Nasopharyngeal Carcinoma Proton therapy, Proton radiation therapy - Recurrent Nasopharyngeal Carcinoma | Not applicable | Recruiting | Guangzhou Concord Cancer Center | 52 | 2025-03-10 | 2026-03-09 |
| Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer Biospecimen Collection, Proton Beam Radiation Therapy, Radiology, Treatment Planning - Resectable Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Emory University | 10 | 2024-12-13 | 2026-09-16 |
| Varian ProBeam360° Proton Therapy System China Clinical Trial (Wuhan) Proton Radiation Therapy - Tumor, Solid | Not applicable | Completed | Varian, a Siemens Healthineers Company | 47 | 2024-09-05 | 2025-12-15 |
| Study on the Safety and Effectiveness of Varian ProBeam Proton Therapy Equipment in the Treatment of Solid Tumors Proton radiation therapy - Solid Tumor, Radiation Therapy | Not applicable | Completed | Guangzhou Concord Cancer Center | 47 | 2022-12-15 | 2023-11-07 |
| Folfox+Irinotecan+Chemort In Esophageal Cancer FOLFOX/ nal-IRI, Paclitaxel, Carboplatin - Gastroesophageal Junction Adenocarcinoma, Esophagogastric Cancer | Phase 2 | Recruiting | Massachusetts General Hospital | 40 | 2021-06-29 | 2025-11-14 |
| Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma Carboplatin, Cisplatin, Computed Tomography - Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 188 | 2021-04-27 | 2026-10-21 |
| Proton Radiation Therapy for the Treatment of Patients With High Risk Prostate Cancer High-Dose Rate Brachytherapy, Proton Beam Radiation Therapy, Quality-of-Life Assessment - Stage III Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8 | Not applicable | Recruiting | Emory University | 30 | 2021-02-01 | 2026-02-17 |
| Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer Proton Beam Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration - Locally Advanced Head and Neck Squamous Cell Carcinoma, Locally Advanced Hypopharyngeal Squamous Cell Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 3 | 2020-10-19 | 2024-10-29 |
| Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients Proton Beam Radiation Therapy, Questionnaire Administration, X-ray Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 3 | Active not recruiting | Mayo Clinic | 146 | 2020-06-16 | 2026-01-16 |
| Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study Hypofractionated Radiation Therapy, Photon Beam Radiation Therapy, Proton Beam Radiation Therapy - Grade I Meningioma, Grade II Meningioma | Not applicable | Recruiting | Emory University | 70 | 2020-02-18 | 2026-02-17 |
| A Study To Evaluate Hypofractionated Proton Therapy Or IMRT For Recurrent, Oligometastatic Prostate Cancer Intensity-Modulated Radiation Therapy, Proton Beam Radiation Therapy, Quality-of-Life Assessment - Metastatic Prostate Adenocarcinoma, Oligometastatic Prostate Carcinoma | Phase 2 | Active not recruiting | Mayo Clinic | 84 | 2020-01-06 | 2026-10-20 |
| Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer Biospecimen Collection, Capecitabine, Carboplatin - Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8 | Phase 3 | Active not recruiting | NRG Oncology | 300 | 2019-06-26 | 2026-08-24 |
| 18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy Computed Tomography, Fluorodopa F 18, Magnetic Resonance Imaging - Glioblastoma, Malignant Glioma | Phase 2 | Completed | Mayo Clinic | 43 | 2019-03-28 | 2025-07-03 |
| Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors Magnetic Resonance Spectroscopic Imaging, Proton Therapy - Malignant Brain Glioma | Not applicable | Recruiting | Emory University | 25 | 2018-12-20 | 2026-03-04 |
| Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma Biospecimen Collection, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma | Phase 2 | Active not recruiting | NRG Oncology | 120 | 2018-01-23 | 2026-07-28 |
| Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery Biospecimen Collection, Clinical Observation, Intensity-Modulated Radiation Therapy - Grade 2 Meningioma, Intracranial Meningioma | Phase 3 | Active not recruiting | NRG Oncology | 162 | 2017-09-12 | 2026-10-02 |
| Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery Carboplatin, Cisplatin, Etoposide - Recurrent Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Completed | Mayo Clinic | 20 | 2017-07-31 | 2025-11-25 |
| Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Malignant Solid Neoplasm, Metastatic Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 124 | 2015-09-17 | 2026-05-15 |
| Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Photon Beam Radiation Therapy, Proton Beam Radiation Therapy, Temozolomide - Glioblastoma | Phase 2 | Active not recruiting | NRG Oncology | 624 | 2014-12-04 | 2026-10-01 |
| Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer Carboplatin, Cisplatin, Durvalumab - Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 | Phase 3 | Active not recruiting | Radiation Therapy Oncology Group | 330 | 2014-01-03 | 2026-06-08 |
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Carcinoma, Non-Small-Cell Lung (4) · Breast Neoplasms (2) · Carcinoma, Hepatocellular (2) · Glioblastoma (2) · Glioma (2) · Liver Neoplasms (2) · Meningioma (2) · Nasopharyngeal Carcinoma (2) · Prostatic Neoplasms (2) · Squamous Cell Carcinoma of Head and Neck (2) · Astrocytoma (1) · Brain Neoplasms (1) · Breast Carcinoma In Situ (1) · Carcinoma (1) · Carcinoma, Adenoid Cystic (1)
M.D. Anderson Cancer Center (7) · Emory University (4) · Massachusetts General Hospital (4) · Mayo Clinic (4) · NRG Oncology (4) · Loma Linda University (3) · Guangzhou Concord Cancer Center (2) · Abramson Cancer Center at Penn Medicine (1) · National Cancer Institute (NCI) (1) · Radiation Therapy Oncology Group (1) · Varian, a Siemens Healthineers Company (1)
United States (29) · China (3) · Canada (2) · India (1) · Japan (1) · Saudi Arabia (1)
David A. Bush, MD (2) · Jerry D. Slater, MD (2) · Steven J Frank (2) · Zhongxing Liao (2) · Andrea Russo, MD (1) · Annie W Chan, MD (1) · Bree R Eaton (1) · Bree R Eaton, MD (1) · Brian J. Davis, M.D. (1) · Carlos E. Vargas, M.D. (1) · Clifton D Fuller (1) · Dan P Zandberg (1) · David A Bush, MD (1) · David R Grosshans (1) · Helen A. Shih, MD, MS, MPH (1)
PMID 15508084, PMID 17476139, PMID 21264826, PMID 21729673, PMID 25084608, PMID 27084653, PMID 31996395, PMID 32615102, PMID 33051340, PMID 33096027, PMID 34749885, PMID 34841093, PMID 35116390, PMID 39571596, PMID 41005671, PMID 41290309, PMID 41391462
U10CA180868 (5), P30CA138292 (4), P01CA021239 (2), U19CA021239 (2), P50CA127001 (1), R03CA188162 (1), R56DE025248 (1), U10CA021661 (1), U10CA180820 (1), U10CA180822 (1)