12 active not recruiting, 11 completed, 5 recruiting, 3 terminated. 20 Phase 2, 8 Not applicable, 7 Phase 1, 5 Phase 3.
Follow Proton Beam Radiation Therapy: new trials by email Literature Review of Proton Beam Radiation Therapy trials Research Report on Proton Beam Radiation Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer Biospecimen Collection, Proton Beam Radiation Therapy, Radiology, Treatment Planning - Resectable Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Emory University | 10 | 2024-12-13 | 2026-09-16 |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
| Pivotal Study of Proton Radiotherapy Treatments Using Fixed Beam Chair-Based Delivery System Proton Radiation - Thoracic Cancer, Pancreatic Cancer Non-resectable | Not applicable | Unknown | P-Cure | 100 | 2023-03-30 | 2023-07-10 |
| Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma Carboplatin, Cisplatin, Computed Tomography - Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 188 | 2021-04-27 | 2026-10-21 |
| Proton Radiation Therapy for the Treatment of Patients With High Risk Prostate Cancer High-Dose Rate Brachytherapy, Proton Beam Radiation Therapy, Quality-of-Life Assessment - Stage III Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8 | Not applicable | Recruiting | Emory University | 30 | 2021-02-01 | 2026-02-17 |
| Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer Proton Beam Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration - Locally Advanced Head and Neck Squamous Cell Carcinoma, Locally Advanced Hypopharyngeal Squamous Cell Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 3 | 2020-10-19 | 2024-10-29 |
| Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients Proton Beam Radiation Therapy, Questionnaire Administration, X-ray Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 3 | Active not recruiting | Mayo Clinic | 146 | 2020-06-16 | 2026-01-16 |
| Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study Hypofractionated Radiation Therapy, Photon Beam Radiation Therapy, Proton Beam Radiation Therapy - Grade I Meningioma, Grade II Meningioma | Not applicable | Recruiting | Emory University | 70 | 2020-02-18 | 2026-02-17 |
| A Study To Evaluate Hypofractionated Proton Therapy Or IMRT For Recurrent, Oligometastatic Prostate Cancer Intensity-Modulated Radiation Therapy, Proton Beam Radiation Therapy, Quality-of-Life Assessment - Metastatic Prostate Adenocarcinoma, Oligometastatic Prostate Carcinoma | Phase 2 | Active not recruiting | Mayo Clinic | 84 | 2020-01-06 | 2026-10-20 |
| Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer Biospecimen Collection, Capecitabine, Carboplatin - Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8 | Phase 3 | Active not recruiting | NRG Oncology | 300 | 2019-06-26 | 2026-08-24 |
| 18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy Computed Tomography, Fluorodopa F 18, Magnetic Resonance Imaging - Glioblastoma, Malignant Glioma | Phase 2 | Completed | Mayo Clinic | 43 | 2019-03-28 | 2025-07-03 |
| Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma Biospecimen Collection, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma | Phase 2 | Active not recruiting | NRG Oncology | 120 | 2018-01-23 | 2026-07-28 |
| Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery Biospecimen Collection, Clinical Observation, Intensity-Modulated Radiation Therapy - Grade 2 Meningioma, Intracranial Meningioma | Phase 3 | Active not recruiting | NRG Oncology | 162 | 2017-09-12 | 2026-10-02 |
| Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery Carboplatin, Cisplatin, Etoposide - Recurrent Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Completed | Mayo Clinic | 20 | 2017-07-31 | 2025-11-25 |
| Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Malignant Solid Neoplasm, Metastatic Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 124 | 2015-09-17 | 2026-05-15 |
| Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Photon Beam Radiation Therapy, Proton Beam Radiation Therapy, Temozolomide - Glioblastoma | Phase 2 | Active not recruiting | NRG Oncology | 624 | 2014-12-04 | 2026-10-01 |
| Proton Beam Re-Irradiation in Thoracic Cancers Proton Beam Radiation Therapy - Metastatic Malignant Neoplasm in the Lung, Recurrent Disease | Not applicable | Completed | University of Washington | 6 | 2014-09-09 | 2018-11-20 |
| Phase II Study of Proton Radiation Therapy for Neuroblastoma Proton Beam Radiation Therapy - Neuroblastoma, Ganglioneuroblastoma | Not applicable | Active not recruiting | Massachusetts General Hospital | 30 | 2014-06-01 | 2026-08-20 |
| Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer Carboplatin, Cisplatin, Durvalumab - Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 | Phase 3 | Active not recruiting | Radiation Therapy Oncology Group | 330 | 2014-01-03 | 2026-06-08 |
| Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors vincristine, doxorubicin, cyclophosphamide - Desmoplastic Small Round Cell Tumor, Ewing Sarcoma of Bone or Soft Tissue | Phase 2 | Completed | St. Jude Children's Research Hospital | 24 | 2013-12-27 | 2026-08-21 |
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Carcinoma, Non-Small-Cell Lung (6) · Brain Neoplasms (5) · Glioblastoma (4) · Glioma (3) · Prostatic Neoplasms (3) · Astrocytoma (2) · Breast Carcinoma In Situ (2) · Breast Neoplasms (2) · Carcinoma, Intraductal, Noninfiltrating (2) · Gliosarcoma (2) · Meningioma (2) · Nerve Sheath Neoplasms (2) · Oligodendroglioma (2) · Sarcoma (2) · Squamous Cell Carcinoma of Head and Neck (2)
M.D. Anderson Cancer Center (7) · Abramson Cancer Center at Penn Medicine (6) · Mayo Clinic (4) · NRG Oncology (4) · Emory University (3) · Radiation Therapy Oncology Group (2) · St. Jude Children's Research Hospital (2) · Albert Einstein College of Medicine (1) · Fred Hutchinson Cancer Center (1) · Massachusetts General Hospital (1) · National Cancer Institute (NCI) (1) · P-Cure (1) · University of Washington (1)
United States (32) · Canada (2) · India (1) · Israel (1) · Japan (1) · Saudi Arabia (1)
Steven J Frank (2) · Zhongxing Liao (2) · Adam P. Dicker, MD, PhD (1) · Bree R Eaton (1) · Brian J. Davis, M.D. (1) · Carlos E. Vargas, M.D. (1) · Christina Tsien (1) · Clifton D Fuller (1) · Curtiland Deville, MD (1) · Dan Gombos, MD (1) · Dan P Zandberg (1) · David R Grosshans (1) · Hans-Peter Kiem (1) · Jacob Shabason, MD (1) · James Welsh (1)
PMID 23388559, PMID 25105369, PMID 27084653, PMID 31996395, PMID 32615102, PMID 33051340, PMID 33096027, PMID 34749885, PMID 34841093, PMID 36260832, PMID 37201756, PMID 39571596, PMID 41005671, PMID 41290309, PMID 41391462
U10CA180868 (5), P30CA138292 (3), U10CA021661 (2), U19CA021239 (2), P01CA021239 (1), P30CA013330 (1), P30CA015704 (1), P50CA127001 (1), R03CA188162 (1), R56DE025248 (1), U10CA180820 (1), U10CA180822 (1)