23 completed, 6 terminated, 3 unknown, 1 not yet recruiting. 9 Phase 3, 9 Phase 4, 7 Not applicable, 5 Phase 2, 3 Phase 1.
Follow Promethazine: new trials by email Literature Review of Promethazine trials Research Report on Promethazine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy. Hibernation-like Therapy (Chlorpromazine and Promethazine, C+P) - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Ji Xunming,MD,PhD | 57 | 2026-01-01 | 2026-01-23 |
| Study on Hibernation-like Therapy Based on Mechanical Thrombectomy chlorpromazine and promethazine, Placebo group, endovascular thrombectomy - Acute Ischemic Stroke | Phase 1 | Recruiting | Capital Medical University | 32 | 2024-11-09 | 2024-12-20 |
| Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance DPI-386 Nasal Gel, Other (e.g., promethazine, meclizine) - Motion Sickness, Space, Motion Simulation | Phase 2 | Unknown | Repurposed Therapeutics, Inc. | 80 | 2021-08-10 | 2024-05-16 |
| Treatment of Pruritus With Intramuscular Promethazine Promethazine, Placebo - Pruritus, Pregnancy Related | Phase 4 | Completed | University of Florida | 72 | 2021-08-09 | 2025-05-04 |
| TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting Haloperidol + Promethazine + Chlorpromazine, Haloperidol + Promethazine - Psychiatric Emergency, Aggression | Phase 4 | Completed | Joseph Dib | 100 | 2018-08-28 | 2022-06-14 |
| Therapeutic Rest to Delay Admission in Early Labor: A Prospective Study on Morphine Sleep Morphine Sulfate and Promethazine - Labor Pain, Early Labor | Completed | University of California, San Francisco | 82 | 2017-09-27 | 2020-07-29 | |
| A Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg for Acute Pain and the Prevention of OINV CL-108 5 mg, Norco, Placebo - Pain, Nausea | Phase 3 | Completed | Charleston Laboratories, Inc | 349 | 2017-08-02 | 2023-03-22 |
| Treatment Modalities of Oral Lichen Planus Dexamethasone - Oral Lichen Planus | Early Phase 1 | Unknown | University of Faisalabad | 32 | 2017-06-01 | 2017-08-02 |
| Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease Fluconazole, Vancomycin, Neomycin - Crohn's Disease | Phase 2 | Completed | University of Pennsylvania | 8 | 2016-08-01 | 2024-02-06 |
| Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis Automated recommendation at the start of the case, Automated notification at the start of surgery, Preoperative recommendations: by email - Postoperative Nausea and Vomiting | Not applicable | Completed | Vanderbilt University | 27034 | 2016-07-01 | 2019-03-07 |
| Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV) Electrical Stimulation, Zofran, Dexamethasone - Post-Operative Nausea and Vomiting, Breast Cancer | Not applicable | Completed | M.D. Anderson Cancer Center | 188 | 2016-03-01 | 2025-12-05 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| A Four-Period, Four-Treatment, Four-Way Relative Bioavailability Study of CL-108 Under Fed and Fasted Conditions CL-108, Vicoprofen, Ultracet - Healthy | Phase 1 | Completed | Charleston Laboratories, Inc | 20 | 2014-11-01 | 2017-05-02 |
| A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV) CL-108 (hydrocodone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg), Placebo, Norco (hyrdocodone 7,5 mg, acetaminophen 325 mg) - Pain, Nausea | Phase 3 | Completed | Joseph Hazelton | 552 | 2014-09-01 | 2016-11-03 |
| Study of Promethazine for Treatment of Diabetic Gastroparesis Promethazine, Sugar pill - Diabetic Gastroparesis | Phase 2 | Terminated | Dartmouth-Hitchcock Medical Center | 3 | 2014-07-01 | 2018-08-07 |
| Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Promethazine, Hyper gravity training, Placebo - Vestibular | Phase 4 | Completed | Faisal_Karmali@MEEI.HARVARD.EDU | 30 | 2014-06-01 | 2018-01-08 |
| Promethazine vs. Lorazepam for Treatment of Vertigo Promethazine, Lorazepam - Peripheral Vertigo. | Phase 3 | Completed | Shahid Beheshti University of Medical Sciences | 210 | 2013-04-01 | 2013-06-14 |
| Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain CL-108 (hydrodocone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg), Placebo - Pain, Nausea | Phase 3 | Completed | Charleston Laboratories, Inc | 460 | 2013-01-01 | 2016-11-03 |
| Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects 2.0mg Buprenorphine/0.5mg Naloxone, Promethazine - Hepatic Failure, Hepatic Impairment | Phase 4 | Completed | Indivior Inc. | 43 | 2012-09-01 | 2016-10-24 |
| Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery Reletex, IV ondansetron 4 mg q 6 hours for a total of 4 doses, IV promethazine 25 mg q 6 hours prn - Nausea and Vomiting Post-foregut Surgery | Not applicable | Completed | Kyle A Perry | 100 | 2011-08-01 | 2014-03-05 |
Showing 20 of 34. Sign in to see all of them.
Nausea (10) · Vomiting (8) · Postoperative Nausea and Vomiting (4) · Pain (3) · Aggression (2) · Ischemic Stroke (2) · Labor Pain (2) · Anxiety Disorders (1) · Breast Neoplasms (1) · Crohn Disease (1) · Dementia (1) · Depression (1) · Hepatitis C (1) · Hyperemesis Gravidarum (1) · Hypersensitivity (1)
Charleston Laboratories, Inc (3) · Vanderbilt University (2) · Capital Medical University (1) · Christian Medical College, Vellore, India (1) · Christiana Care Health Services (1) · Dartmouth-Hitchcock Medical Center (1) · Faisal_Karmali@MEEI.HARVARD.EDU (1) · HaEmek Medical Center, Israel (1) · Hannover Medical School (1) · Indivior Inc. (1) · Ji Xunming,MD,PhD (1) · Joseph Dib (1) · Joseph Hazelton (1) · Kyle A Perry (1) · M.D. Anderson Cancer Center (1)
United States (19) · Iran (2) · Canada (1) · China (1) · Germany (1) · India (1) · Israel (1) · Lebanon (1) · Pakistan (1) · Sri Lanka (1)
Adam Wendling, MD (1) · Alberto A Uribe, M.D. (1) · Alice P Chen, M.D. (1) · Alicia M. Kowalski, MD (1) · Asita de Silva (1) · Bernard Schachtel, MD (1) · Brian E. Lacy, MD (1) · Darren A Braude, MD, MPH (1) · Eric J. Lawitz, MD (1) · Faisal Karmali, Ph.D. (1) · Helge Frieling, Prof., MD (1) · Irwin Plisco, M.D. (1) · James D Lewis, MD, MSCE (1) · Jean Kronberg, MD, PhD (1) · Jonathan P Wanderer, MD, MPhil (1)
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