87 completed, 14 unknown, 7 terminated, 5 recruiting. 55 Phase 4, 28 Phase 3, 15 Phase 2, 9 Phase 1, 7 Not applicable.
Follow Prasugrel: new trials by email Literature Review of Prasugrel trials Research Report on Prasugrel
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months Prasugrel, Ticagrelor - Myocardial Infarction (MI) | Phase 4 | Recruiting | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 8100 | 2026-09-02 | 2026-09-09 |
| Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty. Clopidogrel, Ticagrelor, Prasugrel - Coronary Artery Disease, Percutaneous Coronary Intervention | Phase 3 | Recruiting | Cardiocentro Ticino | 355 | 2026-04-20 | 2026-05-13 |
| Use and Costs of P2Y12 Inhibitors After Acute Myocardial Infarction Clopidogrel, Prasugrel, Ticagrelor - Acute Myocardial Infarction (AMI) | Completed | Brigham and Women's Hospital | 377753 | 2025-11-01 | 2026-07-09 | |
| Dual Antiplatelet Therapy Escalation From Standard-dose Clopidogrel to Low-Dose Prasugrel in Patients With High Bleeding and Ischemic Risk Undergoing PCI: A Prospective, Randomized Pharmacodynamic Study (TAILOR-BLEED-2) Prasugrel, Clopidogrel - Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI) | Phase 4 | Recruiting | University of Florida | 40 | 2025-10-01 | 2026-10-07 |
| Pharmacodynamic Outcomes in CCS Patients Treated With an Individualized Treatment Strategy CYP2C19 genotype guided P2Y12 monotherapy, Clopidogrel - Coronary Artery Disease, Platelet Reactivity | Phase 4 | Unknown | St. Antonius Hospital | 88 | 2024-01-23 | 2024-01-26 |
| Body Weight Adjusted Clopidogrel Treatment in Patients With CORonary Artery Disease Clopidogrel - Coronary Artery Disease, Platelet Reactivity | Phase 2 / Phase 3 | Unknown | St. Antonius Hospital | 80 | 2023-04-26 | 2023-06-02 |
| OPTIMIZE-APT: Tailored Versus Conventional Antiplatelet Therapy After Intravascular Imaging-guided Drug-eluting Stent Implantation aspirin - Coronary Artery Disease | Phase 4 | Recruiting | Asan Medical Center | 3944 | 2022-10-21 | 2026-09-17 |
| Clopidogrel Monotherapy in Patients With High Bleeding Risk Clopidogrel, Prasugrel, Tricagrelor - Bleeding Complications | Phase 4 | Completed | Mayo Clinic | 98 | 2022-03-29 | 2024-02-21 |
| Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI Cangrelor, Prasugrel - Coronary Artery Disease, Acute Coronary Syndrome | Phase 4 | Completed | University of Florida | 359 | 2021-02-18 | 2024-03-20 |
| Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE theraputic heparin, prophylactic heparin, P2Y12 - Covid19 | Phase 4 | Completed | Matthew Neal MD | 3591 | 2020-09-04 | 2024-12-30 |
| Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease Clopidogrel, Prasugrel, ticagrelor - Coronary Artery Disease | Phase 4 | Completed | University of Florida | 90 | 2019-09-06 | 2023-04-26 |
| Comparison of Two Different Antiplatelet Preparations for an Unruptured Intracranial Aneurysm Aspirin, Prasugrel, Clopidogrel - Aneurysm, Cerebral, Endovascular Procedures | Phase 4 | Completed | Seoul National University Hospital | 198 | 2018-10-24 | 2022-04-27 |
| Prasugrel Switching Study in Patients With Acute Coronary Syndrome (ACS) Who Underwent Percutaneous Coronary Intervention (PCI) Prasugrel - Acute Coronary Syndrome (ACS) | Phase 4 | Completed | Daiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company | 204 | 2018-10-16 | 2021-11-12 |
| Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-function: a Validation Study Prasugrel, Ticagrelor - Coronary Artery Disease | Phase 4 | Completed | University of Florida | 14 | 2018-05-30 | 2020-09-16 |
| Daily Variability of Platelet Aggregation in Patients With Myocardial Infarction Treated With Prasugrel and Ticagrelor Prasugrel, Ticagrelor - Acute Myocardial Infarction | Completed | Collegium Medicum w Bydgoszczy | 73 | 2018-02-26 | 2020-02-26 | |
| A Study to Investigate the Interaction Between ACT-246475 and Clopidogrel, Prasugrel, and Ticagrelor in Healthy Subjects ACT-246475, Clopidogrel, Prasugrel - Healthy | Phase 1 | Completed | Viatris Innovation GmbH | 77 | 2018-01-24 | 2025-07-03 |
| Effects of Ticagrelor Versus Prasugrel on Coronary Microcirculation in Patients Undergoing Elective Percutaneous Coronary Intervention: Results of the PROtecting MICROcirculation During Coronary Angioplasty (PROMICRO)-3 Randomised Study Ticagrelor, Prasugrel - Coronary Artery Disease | Phase 4 | Completed | Germano Di Sciascio | 50 | 2017-12-01 | 2022-12-08 |
| Add-on Cangrelor in STEMI-triggered Cardiac Arrest Cangrelor, Placebo, Prasugrel - Cardiopulmonary Arrest With Successful Resuscitation, ACS - Acute Coronary Syndrome | Phase 4 | Unknown | Medical University of Vienna | 60 | 2017-09-01 | 2017-09-13 |
| A Single Center Study to Evaluate Ticagrelor Mechanism of Action in Inhibiting Juvenile Platelet ADP Response Ticagrelor, Prasugrel - Diabetes Mellitus | Phase 4 | Withdrawn | CirQuest Labs, LLC | 2017-08-28 | 2020-07-15 | |
| Randomized Comparison of Cangrelor, Tirofiban and Prasugrel in Patients With STEMI Referred for Primary PCI. Cangrelor, Tirofiban, Prasugrel - Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 122 | 2017-07-04 | 2020-02-21 |
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Coronary Artery Disease (41) · Acute Coronary Syndrome (34) · ST Elevation Myocardial Infarction (14) · Myocardial Infarction (10) · Cardiovascular Diseases (6) · Anemia, Sickle Cell (4) · Diabetes Mellitus (4) · Heart Diseases (4) · Hemorrhage (3) · Non-ST Elevated Myocardial Infarction (3) · Angina Pectoris (2) · Angina, Stable (2) · Angina, Unstable (2) · Atrial Fibrillation (2) · COVID-19 (2)
Eli Lilly and Company (18) · University of Florida (10) · University of Patras (10) · Deutsches Herzzentrum Muenchen (3) · Gennaro Sardella (3) · Medical University of Vienna (3) · Asan Medical Center (2) · Daiichi Sankyo (2) · Dong-A University (2) · LMU Klinikum (2) · Seoul National University Hospital (2) · St. Antonius Hospital (2) · The Medicines Company (2) · AORTICA Group (1) · Aggredyne, Inc. (1)
United States (41) · Italy (18) · Germany (17) · South Korea (13) · Greece (11) · Netherlands (11) · France (10) · Hungary (8) · Spain (8) · Austria (7) · Belgium (7) · Canada (7) · Poland (7) · Switzerland (7) · United Kingdom (7)
Dominick J Angiolillo, MD, PhD (4) · Dominick Angiolillo, MD, PhD (3) · Julinda Mehilli, MD (3) · Adnan Kastrati, MD (2) · David Antoniucci, MD (2) · Moo Hyun Kim, MD (2) · Adriano Caixeta (1) · Alan R Shuldiner, M.D. (1) · Andreas Gotte, Prof., MD (1) · Annapoorna S Kini, MD MRCP (1) · Arintaya Phrommintikul, M.D. (1)
PMID 35224730, PMID 34473343, PMID 36942550, PMID 37489818, PMID 40875095, PMID 17982182, PMID 18377975, PMID 18498956, PMID 18757948, PMID 19106084, PMID 19249633, PMID 19699846, PMID 20026770, PMID 20598967, PMID 20723851, PMID 21252171, PMID 21473962, PMID 21511219, PMID 21606391, PMID 22199016, PMID 22363016, PMID 22372531, PMID 22440491, PMID 22520250, PMID 22554598, PMID 22633653, PMID 22646240, PMID 22698488, PMID 22783896, PMID 22789884, PMID 22869857, PMID 22920930, PMID 22995726, PMID 23048056, PMID 23083774, PMID 23117779, PMID 23169985, PMID 23237136, PMID 23448344, PMID 23491524, PMID 23500251, PMID 23594617, PMID 23594968, PMID 23602770, PMID 23735473, PMID 23747759, PMID 23886748, PMID 23953385, PMID 23991622, PMID 24012432
2014 (2), 2023 (2), 1OT2HL156812-01 (1), 2008 (1), 2015 (1), 2016 (1), U01HL105198 (1)