18 completed. 18 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 18 |
Follow Pitocin: new trials by email Literature Review of Pitocin trials Research Report on Pitocin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain Intravenous oxytocin, Intravenous placebo, Intranasal oxytocin - Pain, Acute | Phase 2 | Completed | Wake Forest University Health Sciences | 24 | 2025-11-05 | 2026-06-30 |
| Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin Oxytocin - Acute Pain, Chronic Pain | Phase 2 | Completed | Wake Forest University Health Sciences | 25 | 2023-08-17 | 2025-10-28 |
| Peripheral Oxytocin and Touch Pitocin - Healthy Adults | Phase 2 | Completed | University of California, San Diego | 20 | 2023-04-05 | 2024-12-31 |
| Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain Low dose oxytocin, High dose oxytocin - Healthy Volunteer Study | Phase 2 | Completed | Wake Forest University Health Sciences | 25 | 2022-05-09 | 2024-03-19 |
| Brief Cognitive Behavioral Conjoint Therapy for PTSD With Adjunctive Intranasal Oxytocin Oxytocin nasal spray, Brief Cognitive-Behavioral Conjoint Therapy - Post Traumatic Stress Disorder, Relational Problems | Phase 2 | Completed | San Diego Veterans Healthcare System | 20 | 2022-01-17 | 2023-07-10 |
| Oxytocin to Treat PTSD Oxytocin, Placebo - PTSD | Phase 2 | Completed | VA Office of Research and Development | 180 | 2021-01-01 | 2026-03-11 |
| Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT) Oxytocin, Placebo - Alcohol Use Disorder, Couples | Phase 2 | Completed | Medical University of South Carolina | 192 | 2019-05-16 | 2025-02-21 |
| Oxytocin, Alcohol Craving, and Intimate Partner Aggression Oxytocin, Placebo - Alcohol Use | Phase 2 | Completed | Medical University of South Carolina | 200 | 2017-07-01 | 2022-05-09 |
| Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders Oxytocin, Placebo - Mood Disorder, Disruptive Behavior Disorders | Phase 2 | Completed | University of Nebraska | 58 | 2017-01-27 | 2023-10-05 |
| Oxytocin and Stress Response in Alcohol Use Disorder Oxytocin, Placebo - Alcohol Use Disorder | Phase 2 | Completed | Medical University of South Carolina | 11 | 2016-03-01 | 2019-10-23 |
| Oxytocin and Affect Processing in Posttraumatic Stress Disorder Oxytocin, Placebo - Posttraumatic Stress Disorder (PTSD) | Phase 2 | Completed | Yale University | 11 | 2015-08-01 | 2020-04-08 |
| Neural Substrates of Emotion: Impact of Cocaine Dependence Oxytocin, Placebo - Cocaine Use Disorder | Phase 2 | Completed | Medical University of South Carolina | 138 | 2015-07-01 | 2021-10-21 |
| Prolonged Exposure and Oxytocin Oxytocin, Placebos - PTSD | Phase 2 | Completed | Medical University of South Carolina | 17 | 2015-01-01 | 2018-05-25 |
| Oxytocin for Couples Conflict Resolution Oxytocin, Placebo - Substance Misuse, Interpersonal Conflict | Phase 2 | Completed | Medical University of South Carolina | 66 | 2014-06-01 | 2018-10-12 |
| Sex/Gender Differences in Risk and Resilience to PTSD; Implication of Oxytocin Oxytocin, Placebo - PTSD | Phase 2 | Completed | Megan Moran-Santa Maria | 38 | 2013-04-01 | 2018-12-11 |
| Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section Carbetocin, Oxytocin - Postpartum Hemorrhage | Phase 2 | Completed | Shahid Beheshti University of Medical Sciences | 220 | 2012-09-01 | 2014-03-06 |
| Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals oxytocin, saline - Cocaine Dependence | Phase 2 | Completed | Medical University of South Carolina | 33 | 2011-07-01 | 2018-06-04 |
| Effects of Oxytocin Nasal Spray on Social Affiliation Oxytocin, Placebo - Schizophrenia | Phase 2 | Completed | University of Maryland, Baltimore | 27 | 2009-10-01 | 2019-09-09 |
Stress Disorders, Post-Traumatic (5) · Acute Pain (2) · Alcoholism (2) · Aggression (1) · Agnosia (1) · Alcohol Drinking (1) · Attention Deficit and Disruptive Behavior Disorders (1) · Chronic Pain (1) · Cocaine-Related Disorders (1) · Mood Disorders (1) · Postpartum Hemorrhage (1) · Psychological Well-Being (1) · Schizophrenia (1)
Medical University of South Carolina (7) · Wake Forest University Health Sciences (3) · Megan Moran-Santa Maria (1) · San Diego Veterans Healthcare System (1) · Shahid Beheshti University of Medical Sciences (1) · University of California, San Diego (1) · University of Maryland, Baltimore (1) · University of Nebraska (1) · VA Office of Research and Development (1) · Yale University (1)
United States (15) · Iran (1)
James C Eisenach, MD (3) · Aimee L McRae-Clark, PharmD (1) · Jane Joseph, PhD (1) · Julianne C Flanagan, Ph.D. (1) · Julianne Christina Flanagan, PhD (1) · Julianne Flanagan, PhD (1) · L E Hong, M.D. (1) · Leslie Morland, PsyD (1) · Linda Mayes, MD (1) · Megan Moran- Santa Maria, PhD (1) · Megan Moran-Santa Maria, Ph.D. (1) · Robabeh Taheripanah, MD-Gyn. (1) · Soonjo Hwang, MD (1)
PMID 28707488, PMID 29294429, PMID 32561468, PMID 34288223, PMID 34455213, PMID 40392716, PMID 41129363, PMID 42400312
K12HD055885 (1), P01NS119159 (1), P50MH082999 (1), R01AA027212 (1)