24 completed, 14 unknown, 2 terminated, 1 active not recruiting. 14 Not applicable, 11 Phase 2, 10 Phase 4, 6 Phase 3, 4 Phase 1.
Follow physiological saline: new trials by email Literature Review of physiological saline trials Research Report on physiological saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P) PTP-01, Placebo control / saline vehicle - Knee Osteoarthritis | Phase 3 | Recruiting | Doron Therapeutics Inc. | 300 | 2025-10-14 | 2026-10-16 |
| Evaluation of Antimicrobial Potency of Garlic Lemon Extract Irrigant Versus Physiological Saline Irrigant Garlic-Lemon Extract irrigant, physiological saline - Necrotic Primary Teeth | Not applicable | Not yet recruiting | Cairo University | 38 | 2025-01-01 | 2025-01-07 |
| The Effect of Tranexamic Acid in Endoscopic and Microscopic Ear Surgery Cases on Surgeon Satisfaction Transamine 10% IV/IM Solution for Injection, %0.9 Saline - Middle Ear Disease | Not applicable | Completed | TC Erciyes University | 100 | 2024-12-01 | 2025-09-08 |
| Clinical Observations of Pain and Pruritus Induced by Exposure to Allergic Contact Dermatitis Caused by Macrolides Erythromycin, Azithromycin, physiological saline - Dermatitis, Allergic Contact | Unknown | Affiliated Hospital of Nantong University | 30 | 2024-09-01 | 2024-08-27 | |
| The Analgesic Efficacy of Pericapsular Nerve Group (PENG) Block in Patients Undergoing Primary Total Hip Arthoplasty: Ropivacaine, Physiological saline - Prospective, Randomized | Not applicable | Unknown | Diakonie-Klinikum Stuttgart | 110 | 2024-03-07 | 2024-08-16 |
| Effect of Dexmedetomidine on Central Nervous System Complications in Patients Undergoing Cardiac Surgery Dexmedetomidine, physiological saline - Randomized Controlled Trial, Dexmedetomidine | Phase 4 | Completed | Chinese PLA General Hospital | 200 | 2024-01-01 | 2024-09-04 |
| RCT Study of Levosimendan Improving Prognosis of Cardiac Arrest Levosimendan Injection, physiological saline - Heart Arrest | Phase 4 | Unknown | Peking University Third Hospital | 60 | 2023-08-01 | 2023-07-21 |
| PreOperative Methylprednisolone on Thoracic Endovascular Repair for Reducing Post-implantation Syndrome (POMTEVAR) methylprednisolone, physiological saline - Methylprednisolone, Thoracic Endovascular Repair | Not applicable | Unknown | Guangdong Provincial People's Hospital | 158 | 2022-05-01 | 2022-04-27 |
| Effect of EA Combined With NGF on Limb Function in Convalescent Patients With Ischemic Stroke nerve growth factor, physiological saline, EA - Ischemic Stroke | Not applicable | Unknown | The Third Affiliated hospital of Zhejiang Chinese Medical University | 120 | 2022-03-01 | 2022-12-15 |
| Efficacy and Safety Trial of PTP-001 (MOTYS) for Symptomatic Knee Osteoarthritis PTP-001, Placebo control - Osteoarthritis, Knee | Phase 2 | Active not recruiting | Bioventus LLC | 210 | 2021-09-30 | 2022-07-19 |
| Sodium Bicarbonate Ringer's Solution Versus Normal Saline for Early Fluid Resuscitation in Patients With Sepsis Sodium Bicarbonate Ringer's Solution, Normal Saline - Sepsis, Septic Shock | Not applicable | Unknown | Xiangya Hospital of Central South University | 450 | 2021-03-11 | 2022-04-04 |
| Postoperative Pain Intensity After Pulpotomy Physiological saline, Hemostasis and cavity disinfection with NaOCl, Hemostasis and cavity disinfection with KTP laser - Symptomatic Irreversible Pulpitis | Phase 4 | Completed | Cumhuriyet University | 90 | 2021-02-15 | 2022-06-28 |
| The Efficacy and Safety of S-ketamine in Elective Cesarean Section S-ketamine, normal saline - Anesthesia, Analgesia | Not applicable | Unknown | Beijing Obstetrics and Gynecology Hospital | 402 | 2020-12-01 | 2020-12-08 |
| Study the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Infection in Colorectal Surgery Amoxicillin Clavulanate, Physiological Saline - Surgical Wound Infection, Postoperative Wound Infection | Phase 4 | Completed | Universitat Internacional de Catalunya | 268 | 2020-10-20 | 2023-06-13 |
| Effects of MSCs Derived Pleiotropic Factors on Wound Healing in Endonasal Surgeries MSCs Derived Pleiotropic Factors, physiological saline - MSCs Derived Pleiotropic Factors on Wound Healing in Endonasal Surgeries | Phase 1 | Unknown | Chinese PLA General Hospital | 50 | 2020-10-10 | 2020-09-29 |
| Inflammation Reduction by TREhalose AdminisTration Trehalose, Normal saline - Acute Coronary Syndrome | Phase 2 | Unknown | Mashhad University of Medical Sciences | 15 | 2020-08-20 | 2020-09-21 |
| KW-3357 Study in Patients With Early Onset Severe Preeclampsia Antithrombin gamma, physiological saline - Preeclampsia | Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 181 | 2019-11-19 | 2023-11-15 |
| Safety Study of Dexmedetomidine in Elderly Under General Anesthesia Dexmedetomidine, Normal saline, Midazolam - Hip Fractures, Hip Disease | Phase 4 | Completed | Zhenjiang First People's Hospital | 200 | 2019-06-01 | 2022-10-13 |
| Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery Ferric carboxymaltose, Physiological saline - Coronary Artery Disease, Postoperative Complications | Phase 4 | Unknown | Turku University Hospital | 210 | 2018-10-02 | 2021-04-20 |
| Preventive Intramuscular Phenylephrine in Elective Cesarean Section Under Spinal Anesthesia Phenylephrine, Normal saline, Bupivacaine - Elective Cesarean Section, Spinal Anesthesia | Not applicable | Completed | Xuzhou Medical University | 99 | 2018-04-01 | 2019-07-05 |
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Osteoarthritis, Knee (3) · Pain, Postoperative (2) · Postoperative Complications (2) · Surgical Wound Infection (2) · Acute Coronary Syndrome (1) · Agnosia (1) · Aortic Aneurysm, Abdominal (1) · Aortic Aneurysm, Thoracic (1) · Aortic Valve Stenosis (1) · Arteritis (1) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Cerebral Palsy (1) · Convalescence (1) · Coronary Artery Disease (1)
Shengjing Hospital (3) · Chinese PLA General Hospital (2) · Affiliated Hospital of Nantong University (1) · Beijing Obstetrics and Gynecology Hospital (1) · Bioventus LLC (1) · Cairo University (1) · Clinique Mutualiste Chirurgicale de la Loire (1) · Copenhagen University Hospital, Rigshospitalet (1) · Cumhuriyet University (1) · Diakonie-Klinikum Stuttgart (1) · Doron Therapeutics Inc. (1) · Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (1) · General Hospital of Chinese Armed Police Forces (1) · GlaxoSmithKline (1) · Guangdong Provincial People's Hospital (1)
China (12) · Spain (5) · Denmark (4) · United States (3) · Australia (2) · France (2) · Japan (2) · Turkey (Türkiye) (2) · Austria (1) · Canada (1) · Croatia (1) · Finland (1) · Germany (1) · India (1) · Iran (1)
Alfonso Leon Garcia (1) · Chao Xu, M.D. (1) · Fernando Marques Lopez (1) · Francisco Javier Santiveri Papiol (1) · Haitong Liu (1) · Hans-Joergen Malling, Prof. Dr. Med. (1) · Hatice Kumru, MD PhD (1) · J Marinel-lo, MD (1) · JR March, MD (1) · Jianfang Luo, MD (1)
PMID 10219875, PMID 11294711, PMID 12439804, PMID 12603990, PMID 12963381, PMID 15273542, PMID 15620935, PMID 15909433, PMID 16311286, PMID 1656747, PMID 17215703, PMID 17235400, PMID 17883362, PMID 17932825, PMID 18564784, PMID 18655991, PMID 18957455, PMID 19281889, PMID 19374211, PMID 1951905, PMID 19638912, PMID 22759268, PMID 24624090, PMID 24745317, PMID 25115430, PMID 25129595, PMID 25637469, PMID 26090835, PMID 26170157, PMID 27020488, PMID 27477797, PMID 28235526, PMID 2868173, PMID 29408507, PMID 29553001, PMID 29659182, PMID 29704562, PMID 30019145, PMID 30286812, PMID 30407329, PMID 3064867, PMID 31611935, PMID 31724910, PMID 31996985, PMID 34023528, PMID 34484101, PMID 34774274, PMID 35304900, PMID 35427799, PMID 3558716
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